Sicen Liu

Sicen Liu, Xiaolong Wang, JIngcheng Du et al.

Effectively medication recommendation with complex multimorbidity conditions is a critical task in healthcare. Most existing works predicted medications based on longitudinal records, which assumed the information transmitted patterns of learning longitudinal sequence data are stable and intra-visit medical events are serialized. However, the following conditions may have been ignored: 1) A more compact encoder for intra-relationship in the intra-visit medical event is urgent; 2) Strategies for learning accurate representations of the variable longitudinal sequences of patients are different. In this paper, we proposed a novel Sample-adaptive Hierarchical medicAtion Prediction nEtwork, termed SHAPE, to tackle the above challenges in the medication recommendation task. Specifically, we design a compact intra-visit set encoder to encode the relationship in the medical event for obtaining visit-level representation and then develop an inter-visit longitudinal encoder to learn the patient-level longitudinal representation efficiently. To endow the model with the capability of modeling the variable visit length, we introduce a soft curriculum learning method to assign the difficulty of each sample automatically by the visit length. Extensive experiments on a benchmark dataset verify the superiority of our model compared with several state-of-the-art baselines.

Sicen Liu, Xiaolong Wang, Yang Xiang et al.

Medical event prediction (MEP) is a fundamental task in the medical domain, which needs to predict medical events, including medications, diagnosis codes, laboratory tests, procedures, outcomes, and so on, according to historical medical records. The task is challenging as medical data is a type of complex time series data with heterogeneous and temporal irregular characteristics. Many machine learning methods that consider the two characteristics have been proposed for medical event prediction. However, most of them consider the two characteristics separately and ignore the correlations among different types of medical events, especially relations between historical medical events and target medical events. In this paper, we propose a novel neural network based on attention mechanism, called cross-event attention-based time-aware network (CATNet), for medical event prediction. It is a time-aware, event-aware and task-adaptive method with the following advantages: 1) modeling heterogeneous information and temporal information in a unified way and considering temporal irregular characteristics locally and globally respectively, 2) taking full advantage of correlations among different types of events via cross-event attention. Experiments on two public datasets (MIMIC-III and eICU) show CATNet can be adaptive with different MEP tasks and outperforms other state-of-the-art methods on various MEP tasks. The source code of CATNet will be released after this manuscript is accepted.

Ying Xiao, Shangwen Wang, Sicen Liu et al.

Traditional software fairness research typically emphasizes ethical and social imperatives, neglecting that fairness fundamentally represents a core software quality issue arising directly from performance disparities across sensitive user groups. Recognizing fairness explicitly as a software quality dimension yields practical benefits beyond ethical considerations, notably improved predictive performance for unprivileged groups, enhanced out-of-distribution generalization, and increased geographic transferability in real-world deployments. Nevertheless, existing bias mitigation methods face a critical dilemma: while pre-processing methods offer broad applicability across model types, they generally fall short in effectiveness compared to post-processing techniques. To overcome this challenge, we propose Correlation Tuning (CoT), a novel pre-processing approach designed to mitigate bias by adjusting data correlations. Specifically, CoT introduces the Phi-coefficient, an intuitive correlation measure, to systematically quantify correlation between sensitive attributes and labels, and employs multi-objective optimization to address the proxy biases. Extensive evaluations demonstrate that CoT increases the true positive rate of unprivileged groups by an average of 17.5% and reduces three key bias metrics, including statistical parity difference (SPD), average odds difference (AOD), and equal opportunity difference (EOD), by more than 50% on average. CoT outperforms state-of-the-art methods by three and ten percentage points in single attribute and multiple attributes scenarios, respectively. We will publicly release our experimental results and source code to facilitate future research.

Sicen Liu, Xiaolong Wang, Xianbing Zhao et al.

Medication recommendation is a fundamental yet crucial branch of healthcare that presents opportunities to assist physicians in making more accurate medication prescriptions for patients with complex health conditions. Previous studies have primarily focused on learning patient representation from electronic health records (EHR). While considering the clinical manifestations of the patient is important, incorporating domain-specific prior knowledge is equally significant in diagnosing the patient's health conditions. However, effectively integrating domain knowledge with the patient's clinical manifestations can be challenging, particularly when dealing with complex clinical manifestations. Therefore, in this paper, we first identify comprehensive domain-specific prior knowledge, namely the Unified Medical Language System (UMLS), which is a comprehensive repository of biomedical vocabularies and standards, for knowledge extraction. Subsequently, we propose a knowledge injection module that addresses the effective integration of domain knowledge with complex clinical manifestations, enabling an effective characterization of the health conditions of the patient. Furthermore, considering the significant impact of a patient's medication history on their current medication, we introduce a historical medication-aware patient representation module to capture the longitudinal influence of historical medication information on the representation of current patients. Extensive experiments on three publicly benchmark datasets verify the superiority of our proposed method, which outperformed other methods by a significant margin. The code is available at: https://github.com/sherry6247/DKINet.

Ying Xiao, Shangwen Wang, Sicen Liu et al.

Software built on top of machine learning algorithms is becoming increasingly prevalent in a variety of fields, including college admissions, healthcare, insurance, and justice. The effectiveness and efficiency of these systems heavily depend on the quality of the training datasets. Biased datasets can lead to unfair and potentially harmful outcomes, particularly in such critical decision-making systems where the allocation of resources may be affected. This can exacerbate discrimination against certain groups and cause significant social disruption. To mitigate such unfairness, a series of bias-mitigating methods are proposed. Generally, these studies improve the fairness of the trained models to a certain degree but with the expense of sacrificing the model performance. In this paper, we propose FITNESS, a bias mitigation approach via de-correlating the causal effects between sensitive features (e.g., the sex) and the label. Our key idea is that by de-correlating such effects from a causality perspective, the model would avoid making predictions based on sensitive features and thus fairness could be improved. Furthermore, FITNESS leverages multi-objective optimization to achieve a better performance-fairness trade-off. To evaluate the effectiveness, we compare FITNESS with 7 state-of-the-art methods in 8 benchmark tasks by multiple metrics. Results show that FITNESS can outperform the state-of-the-art methods on bias mitigation while preserve the model's performance: it improved the model's fairness under all the scenarios while decreased the model's performance under only 26.67% of the scenarios. Additionally, FITNESS surpasses the Fairea Baseline in 96.72% cases, outperforming all methods we compared.

Sicen Liu, Xiaolong Wang, Yongshuai Hou et al.

As two important textual modalities in electronic health records (EHR), both structured data (clinical codes) and unstructured data (clinical narratives) have recently been increasingly applied to the healthcare domain. Most existing EHR-oriented studies, however, either focus on a particular modality or integrate data from different modalities in a straightforward manner, which usually treats structured and unstructured data as two independent sources of information about patient admission and ignore the intrinsic interactions between them. In fact, the two modalities are documented during the same encounter where structured data inform the documentation of unstructured data and vice versa. In this paper, we proposed a Medical Multimodal Pre-trained Language Model, named MedM-PLM, to learn enhanced EHR representations over structured and unstructured data and explore the interaction of two modalities. In MedM-PLM, two Transformer-based neural network components are firstly adopted to learn representative characteristics from each modality. A cross-modal module is then introduced to model their interactions. We pre-trained MedM-PLM on the MIMIC-III dataset and verified the effectiveness of the model on three downstream clinical tasks, i.e., medication recommendation, 30-day readmission prediction and ICD coding. Extensive experiments demonstrate the power of MedM-PLM compared with state-of-the-art methods. Further analyses and visualizations show the robustness of our model, which could potentially provide more comprehensive interpretations for clinical decision-making.