Chengkai Wang

Yaqi Wang, Yifan Zhang, Xiaodiao Chen et al.

Computer-aided design (CAD) tools are increasingly popular in modern dental practice, particularly for treatment planning or comprehensive prognosis evaluation. In particular, the 2D panoramic X-ray image efficiently detects invisible caries, impacted teeth and supernumerary teeth in children, while the 3D dental cone beam computed tomography (CBCT) is widely used in orthodontics and endodontics due to its low radiation dose. However, there is no open-access 2D public dataset for children's teeth and no open 3D dental CBCT dataset, which limits the development of automatic algorithms for segmenting teeth and analyzing diseases. The Semi-supervised Teeth Segmentation (STS) Challenge, a pioneering event in tooth segmentation, was held as a part of the MICCAI 2023 ToothFairy Workshop on the Alibaba Tianchi platform. This challenge aims to investigate effective semi-supervised tooth segmentation algorithms to advance the field of dentistry. In this challenge, we provide two modalities including the 2D panoramic X-ray images and the 3D CBCT tooth volumes. In Task 1, the goal was to segment tooth regions in panoramic X-ray images of both adult and pediatric teeth. Task 2 involved segmenting tooth sections using CBCT volumes. Limited labelled images with mostly unlabelled ones were provided in this challenge prompt using semi-supervised algorithms for training. In the preliminary round, the challenge received registration and result submission by 434 teams, with 64 advancing to the final round. This paper summarizes the diverse methods employed by the top-ranking teams in the STS MICCAI 2023 Challenge.

Xiang Feng, Chengkai Wang, Chengyu Wu et al.

Precise Tooth Cone Beam Computed Tomography (CBCT) image segmentation is crucial for orthodontic treatment planning. In this paper, we propose FDNet, a Feature Decoupled Segmentation Network, to excel in the face of the variable dental conditions encountered in CBCT scans, such as complex artifacts and indistinct tooth boundaries. The Low-Frequency Wavelet Transform (LF-Wavelet) is employed to enrich the semantic content by emphasizing the global structural integrity of the teeth, while the SAM encoder is leveraged to refine the boundary delineation, thus improving the contrast between adjacent dental structures. By integrating these dual aspects, FDNet adeptly addresses the semantic gap, providing a detailed and accurate segmentation. The framework's effectiveness is validated through rigorous benchmarks, achieving the top Dice and IoU scores of 85.28% and 75.23%, respectively. This innovative decoupling of semantic and boundary features capitalizes on the unique strengths of each element to elevate the quality of segmentation performance.

Chengyu Wu, Chengkai Wang, Yaqi Wang et al.

Esophageal cancer is one of the most common types of cancer worldwide and ranks sixth in cancer-related mortality. Accurate computer-assisted diagnosis of cancer progression can help physicians effectively customize personalized treatment plans. Currently, CT-based cancer diagnosis methods have received much attention for their comprehensive ability to examine patients' conditions. However, multi-modal based methods may likely introduce information redundancy, leading to underperformance. In addition, efficient and effective interactions between multi-modal representations need to be further explored, lacking insightful exploration of prognostic correlation in multi-modality features. In this work, we introduce a multi-modal heterogeneous graph-based conditional feature-guided diffusion model for lymph node metastasis diagnosis based on CT images as well as clinical measurements and radiomics data. To explore the intricate relationships between multi-modal features, we construct a heterogeneous graph. Following this, a conditional feature-guided diffusion approach is applied to eliminate information redundancy. Moreover, we propose a masked relational representation learning strategy, aiming to uncover the latent prognostic correlations and priorities of primary tumor and lymph node image representations. Various experimental results validate the effectiveness of our proposed method. The code is available at https://github.com/wuchengyu123/MMFusion.

Xiang Feng, Yongbo He, Yubo Wang et al.

Neural Radiance Fields (NeRF) have achieved great success in the task of synthesizing novel views that preserve the same resolution as the training views. However, it is challenging for NeRF to synthesize high-quality high-resolution novel views with low-resolution training data. To solve this problem, we propose a zero-shot super-resolution training framework for NeRF. This framework aims to guide the NeRF model to synthesize high-resolution novel views via single-scene internal learning rather than requiring any external high-resolution training data. Our approach consists of two stages. First, we learn a scene-specific degradation mapping by performing internal learning on a pretrained low-resolution coarse NeRF. Second, we optimize a super-resolution fine NeRF by conducting inverse rendering with our mapping function so as to backpropagate the gradients from low-resolution 2D space into the super-resolution 3D sampling space. Then, we further introduce a temporal ensemble strategy in the inference phase to compensate for the scene estimation errors. Our method is featured on two points: (1) it does not consume high-resolution views or additional scene data to train super-resolution NeRF; (2) it can speed up the training process by adopting a coarse-to-fine strategy. By conducting extensive experiments on public datasets, we have qualitatively and quantitatively demonstrated the effectiveness of our method.

Chengkai Wang, Baisong Liu

LLM-based explainable recommenders can produce fluent explanations that are factually correct, yet still justify items using attributes that conflict with a user's historical preferences. Such preference-inconsistent explanations yield logically valid but unconvincing reasoning and are largely missed by standard hallucination or faithfulness metrics. We formalize this failure mode and propose PURE, a preference-aware reasoning framework following a select-then-generate paradigm. Instead of only improving generation, PURE intervenes in evidence selection, it selects a compact set of multi-hop item-centric reasoning paths that are both factually grounded and aligned with user preference structure, guided by user intent, specificity, and diversity to suppress generic, weakly personalized evidence. The selected evidence is then injected into LLM generation via structure-aware prompting that preserves relational constraints. To measure preference inconsistency, we introduce a feature-level, user-centric evaluation metric that reveals misalignment overlooked by factuality-based measures. Experiments on three real-world datasets show that PURE consistently reduces preference-inconsistent explanations and factual hallucinations while maintaining competitive recommendation accuracy, explanation quality, and inference efficiency. These results highlight that trustworthy explanations require not only factual correctness but also justification aligned with user preferences.

Xiang Feng, Tieshi Zhong, Shuo Chang et al.

Reconstructing high-resolution (HR) 3D Gaussian Splatting (3DGS) models from low-resolution (LR) inputs remains challenging due to the lack of fine-grained textures and geometry. Existing methods typically rely on pre-trained 2D super-resolution (2DSR) models to enhance textures, but suffer from 3D Gaussian ambiguity arising from cross-view inconsistencies and domain gaps inherent in 2DSR models. We propose IE-SRGS, a novel 3DGS SR paradigm that addresses this issue by jointly leveraging the complementary strengths of external 2DSR priors and internal 3DGS features. Specifically, we use 2DSR and depth estimation models to generate HR images and depth maps as external knowledge, and employ multi-scale 3DGS models to produce cross-view consistent, domain-adaptive counterparts as internal knowledge. A mask-guided fusion strategy is introduced to integrate these two sources and synergistically exploit their complementary strengths, effectively guiding the 3D Gaussian optimization toward high-fidelity reconstruction. Extensive experiments on both synthetic and real-world benchmarks show that IE-SRGS consistently outperforms state-of-the-art methods in both quantitative accuracy and visual fidelity.

Ziyi Zeng, Yun-Hsuan Chen, Xurong Gao et al.

The impact of repetitive transcranial magnetic stimulation (rTMS) on methamphetamine (METH) users' craving levels is often assessed using questionnaires. This study explores the feasibility of using neural signals to obtain more objective results. EEG signals recorded from 20 METH-addicted participants Before and After rTMS (MBT and MAT) and from 20 healthy participants (HC) are analyzed. In each EEG paradigm, participants are shown 15 METH-related and 15 neutral pictures randomly, and the relative band power (RBP) of each EEG sub-band frequency is derived. The average RBP across all 31 channels, as well as individual brain regions, is analyzed. Statistically, MAT's alpha, beta, and gamma RBPs are more like those of HC compared to MBT, as indicated by the power topographies. Utilizing a random forest (RF), the gamma RBP is identified as the optimal frequency band for distinguishing between MBT and HC with a 90% accuracy. The performance of classifying MAT versus HC is lower than that of MBT versus HC, suggesting that the efficacy of rTMS can be validated using RF with gamma RBP. Furthermore, the gamma RBP recorded by the TP10 and CP2 channels dominates the classification task of MBT versus HC when receiving METH-related image cues. The gamma RBP during exposure to METH-related cues can serve as a biomarker for distinguishing between MBT and HC and for evaluating the effectiveness of rTMS. Therefore, real-time monitoring of gamma RBP variations holds promise as a parameter for implementing a customized closed-loop neuromodulation system for treating METH addiction.

Chengkai Wang, Di Wu, Yunsheng Liao et al.

Methamphetamine dependence poses a significant global health challenge, yet its assessment and the evaluation of treatments like repetitive transcranial magnetic stimulation (rTMS) frequently depend on subjective self-reports, which may introduce uncertainties. While objective neuroimaging modalities such as electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) offer alternatives, their individual limitations and the reliance on conventional, often hand-crafted, feature extraction can compromise the reliability of derived biomarkers. To overcome these limitations, we propose NeuroCLIP, a novel deep learning framework integrating simultaneously recorded EEG and fNIRS data through a progressive learning strategy. This approach offers a robust and trustworthy biomarker for methamphetamine addiction. Validation experiments show that NeuroCLIP significantly improves discriminative capabilities among the methamphetamine-dependent individuals and healthy controls compared to models using either EEG or only fNIRS alone. Furthermore, the proposed framework facilitates objective, brain-based evaluation of rTMS treatment efficacy, demonstrating measurable shifts in neural patterns towards healthy control profiles after treatment. Critically, we establish the trustworthiness of the multimodal data-driven biomarker by showing its strong correlation with psychometrically validated craving scores. These findings suggest that biomarker derived from EEG-fNIRS data via NeuroCLIP offers enhanced robustness and reliability over single-modality approaches, providing a valuable tool for addiction neuroscience research and potentially improving clinical assessments.