Peng Bao

Mingze Yuan, Peng Bao, Jiajia Yuan et al.

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to enhance various aspects of healthcare, ranging from medical education to clinical decision support. However, medicine involves multifaceted data modalities and nuanced reasoning skills, presenting challenges for integrating LLMs. This paper provides a comprehensive review on the applications and implications of LLMs in medicine. It begins by examining the fundamental applications of general-purpose and specialized LLMs, demonstrating their utilities in knowledge retrieval, research support, clinical workflow automation, and diagnostic assistance. Recognizing the inherent multimodality of medicine, the review then focuses on multimodal LLMs, investigating their ability to process diverse data types like medical imaging and EHRs to augment diagnostic accuracy. To address LLMs' limitations regarding personalization and complex clinical reasoning, the paper explores the emerging development of LLM-powered autonomous agents for healthcare. Furthermore, it summarizes the evaluation methodologies for assessing LLMs' reliability and safety in medical contexts. Overall, this review offers an extensive analysis on the transformative potential of LLMs in modern medicine. It also highlights the pivotal need for continuous optimizations and ethical oversight before these models can be effectively integrated into clinical practice. Visit https://github.com/mingze-yuan/Awesome-LLM-Healthcare for an accompanying GitHub repository containing latest papers.

Jingwei Yi, Junhao Yin, Ju Xu et al.

Vision-Language Models (VLMs) have demonstrated remarkable capabilities in understanding multimodal inputs and have been widely integrated into Retrieval-Augmented Generation (RAG) based conversational systems. While current VLM-powered chatbots can provide textual source references in their responses, they exhibit significant limitations in referencing contextually relevant images during conversations. In this paper, we introduce Contextual Image Reference -- the ability to appropriately reference relevant images from retrieval documents based on conversation context -- and systematically investigate VLMs' capability in this aspect. We conduct the first evaluation for contextual image referencing, comprising a dedicated testing dataset and evaluation metrics. Furthermore, we propose ImageRef-VL, a method that significantly enhances open-source VLMs' image referencing capabilities through instruction fine-tuning on a large-scale, manually curated multimodal conversation dataset. Experimental results demonstrate that ImageRef-VL not only outperforms proprietary models but also achieves an 88% performance improvement over state-of-the-art open-source VLMs in contextual image referencing tasks. Our code is available at https://github.com/bytedance/ImageRef-VL.

Junhao Yin, Haolin Wang, Peng Bao et al.

Generative query suggestion using large language models offers a powerful way to enhance conversational systems, but aligning outputs with nuanced user preferences remains a critical challenge. To address this, we introduce a multi-stage framework designed for progressive alignment between the generation policy and user intent. Our pipeline begins with prompt engineering as a cold-start strategy, followed by the Supervised Fine-Tuning stage, in which we introduce a distillation method on click logs to create a robust foundational model. To better model user preferences while capturing their inherent uncertainty, we develop a Gaussian Reward Model (GaRM) that represents user preferences as probability distributions rather than point estimates. Finally, we employ reinforcement learning to align the generation policy with these preferences, guided by a composite reward function that integrates GaRM with auxiliary heuristics to mitigate reward hacking. To maintain training stability, this process is enhanced by a novel out-of-distribution regularization method and a two-stage reward fusion technique. Extensive experiments demonstrate that our framework significantly outperforms baselines on both automatic and human evaluations and yields a 34\% relative increase in user engagement as measured by click-through rate in live A/B tests.

Peng Bao, Zonghai Chen, Jikai Wang et al.

Accurate trajectory prediction of vehicles is essential for reliable autonomous driving. To maintain consistent performance as a vehicle driving around different cities, it is crucial to adapt to changing traffic circumstances and achieve lifelong trajectory prediction model. To realize it, catastrophic forgetting is a main problem to be addressed. In this paper, a divergence measurement method based on conditional Kullback-Leibler divergence is proposed first to evaluate spatiotemporal dependency difference among varied driving circumstances. Then based on generative replay, a novel lifelong vehicle trajectory prediction framework is developed. The framework consists of a conditional generation model and a vehicle trajectory prediction model. The conditional generation model is a generative adversarial network conditioned on position configuration of vehicles. After learning and merging trajectory distribution of vehicles across different cities, the generation model replays trajectories with prior samplings as inputs, which alleviates catastrophic forgetting. The vehicle trajectory prediction model is trained by the replayed trajectories and achieves consistent prediction performance on visited cities. A lifelong experiment setup is established on four open datasets including five tasks. Spatiotemporal dependency divergence is calculated for different tasks. Even though these divergence, the proposed framework exhibits lifelong learning ability and achieves consistent performance on all tasks.

Peng Bao, Wenjun Xia, Kang Yang et al.

Over the past few years, dictionary learning (DL)-based methods have been successfully used in various image reconstruction problems. However, traditional DL-based computed tomography (CT) reconstruction methods are patch-based and ignore the consistency of pixels in overlapped patches. In addition, the features learned by these methods always contain shifted versions of the same features. In recent years, convolutional sparse coding (CSC) has been developed to address these problems. In this paper, inspired by several successful applications of CSC in the field of signal processing, we explore the potential of CSC in sparse-view CT reconstruction. By directly working on the whole image, without the necessity of dividing the image into overlapped patches in DL-based methods, the proposed methods can maintain more details and avoid artifacts caused by patch aggregation. With predetermined filters, an alternating scheme is developed to optimize the objective function. Extensive experiments with simulated and real CT data were performed to validate the effectiveness of the proposed methods. Qualitative and quantitative results demonstrate that the proposed methods achieve better performance than several existing state-of-the-art methods.

Peng Bao, Wenjun Xia, Kang Yang et al.

Traditional dictionary learning based CT reconstruction methods are patch-based and the features learned with these methods often contain shifted versions of the same features. To deal with these problems, the convolutional sparse coding (CSC) has been proposed and introduced into various applications. In this paper, inspired by the successful applications of CSC in the field of signal processing, we propose a novel sparse-view CT reconstruction method based on CSC with gradient regularization on feature maps. By directly working on whole image, which need not to divide the image into overlapped patches like dictionary learning based methods, the proposed method can maintain more details and avoid the artifacts caused by patch aggregation. Experimental results demonstrate that the proposed method has better performance than several existing algorithms in both qualitative and quantitative aspects.