Xiangxiang Cui

Yuchen Wang, Zhongyu Li, Xiangxiang Cui et al.

Ultrasound examination is widely used in the clinical diagnosis of thyroid nodules (benign/malignant). However, the accuracy relies heavily on radiologist experience. Although deep learning techniques have been investigated for thyroid nodules recognition. Current solutions are mainly based on static ultrasound images, with limited temporal information used and inconsistent with clinical diagnosis. This paper proposes a novel method for the automated recognition of thyroid nodules through an exhaustive exploration of ultrasound videos and key-frames. We first propose a detection-localization framework to automatically identify the clinical key-frame with a typical nodule in each ultrasound video. Based on the localized key-frame, we develop a key-frame guided video classification model for thyroid nodule recognition. Besides, we introduce a motion attention module to help the network focus on significant frames in an ultrasound video, which is consistent with clinical diagnosis. The proposed thyroid nodule recognition framework is validated on clinically collected ultrasound videos, demonstrating superior performance compared with other state-of-the-art methods.

Xiangxiang Cui, Tianjin Huang, Yifang Wang et al.

Medical foundation models (MedFMs) have emerged as transformative tools in healthcare, demonstrating capabilities across diverse clinical applications. These models can be broadly categorized into two paradigms: Medical Vision-Language Models (Med-VLMs) and segmentation foundation models. Med-VLMs range from medical-specialized models such as LLaVA-Med and MedGemma, to general-purpose models like GPT-4o and Gemini, all capable of medical image understanding tasks including visual question answering (VQA), report generation, and visual grounding. Concurrently, the Segment Anything Model (SAM) has catalyzed a new generation of medical segmentation models, with adaptations like SAM-Med2D and MedSAM. The widespread clinical deployment of these models thus necessitates rigorous evaluation of their reliability under real-world conditions.

Xiangxiang Cui, Zhongyu Li, Xiayue Fan et al.

The intersection of medical imaging and artificial intelligence has become an important research direction in intelligent medical treatment, particularly in the analysis of medical images using deep learning for clinical diagnosis. Despite the advances, existing keyframe classification methods lack extraction of time series features, while ultrasonic video classification based on three-dimensional convolution requires uniform frame numbers across patients, resulting in poor feature extraction efficiency and model classification performance. This study proposes a novel video classification method based on CNN and LSTM, introducing NLP's long and short sentence processing scheme into video classification for the first time. The method reduces CNN-extracted image features to 1x512 dimension, followed by sorting and compressing feature vectors for LSTM training. Specifically, feature vectors are sorted by patient video frame numbers and populated with padding value 0 to form variable batches, with invalid padding values compressed before LSTM training to conserve computing resources. Experimental results demonstrate that our variable-frame CNNLSTM method outperforms other approaches across all metrics, showing improvements of 3-6% in F1 score and 1.5% in specificity compared to keyframe methods. The variable-frame CNNLSTM also achieves better accuracy and precision than equal-frame CNNLSTM. These findings validate the effectiveness of our approach in classifying variable-frame ultrasound videos and suggest potential applications in other medical imaging modalities.

Xiangxiang Cui, Min Zhao, Dongmei Zhi et al.

Existing deep learning models for functional MRI-based classification have limitations in network architecture determination (relying on experience) and feature space fusion (mostly simple concatenation, lacking mutual learning). Inspired by the human brain's mechanism of updating neural connections through learning and decision-making, we proposed a novel BRain-Inspired feature Fusion (BRIEF) framework, which is able to optimize network architecture automatically by incorporating an improved neural network connection search (NCS) strategy and a Transformer-based multi-feature fusion module. Specifically, we first extracted 4 types of fMRI temporal representations, i.e., time series (TCs), static/dynamic functional connection (FNC/dFNC), and multi-scale dispersion entropy (MsDE), to construct four encoders. Within each encoder, we employed a modified Q-learning to dynamically optimize the NCS to extract high-level feature vectors, where the NCS is formulated as a Markov Decision Process. Then, all feature vectors were fused via a Transformer, leveraging both stable/time-varying connections and multi-scale dependencies across different brain regions to achieve the final classification. Additionally, an attention module was embedded to improve interpretability. The classification performance of our proposed BRIEF was compared with 21 state-of-the-art models by discriminating two mental disorders from healthy controls: schizophrenia (SZ, n=1100) and autism spectrum disorder (ASD, n=1550). BRIEF demonstrated significant improvements of 2.2% to 12.1% compared to 21 algorithms, reaching an AUC of 91.5% - 0.6% for SZ and 78.4% - 0.5% for ASD, respectively. This is the first attempt to incorporate a brain-inspired, reinforcement learning strategy to optimize fMRI-based mental disorder classification, showing significant potential for identifying precise neuroimaging biomarkers.

Xiangxiang Cui, Shu Yang, Tianjin Huang et al.

Regret in Large Language Models refers to their explicit regret expression when presented with evidence contradicting their previously generated misinformation. Studying the regret mechanism is crucial for enhancing model reliability and helps in revealing how cognition is coded in neural networks. To understand this mechanism, we need to first identify regret expressions in model outputs, then analyze their internal representation. This analysis requires examining the model's hidden states, where information processing occurs at the neuron level. However, this faces three key challenges: (1) the absence of specialized datasets capturing regret expressions, (2) the lack of metrics to find the optimal regret representation layer, and (3) the lack of metrics for identifying and analyzing regret neurons. Addressing these limitations, we propose: (1) a workflow for constructing a comprehensive regret dataset through strategically designed prompting scenarios, (2) the Supervised Compression-Decoupling Index (S-CDI) metric to identify optimal regret representation layers, and (3) the Regret Dominance Score (RDS) metric to identify regret neurons and the Group Impact Coefficient (GIC) to analyze activation patterns. Our experimental results successfully identified the optimal regret representation layer using the S-CDI metric, which significantly enhanced performance in probe classification experiments. Additionally, we discovered an M-shaped decoupling pattern across model layers, revealing how information processing alternates between coupling and decoupling phases. Through the RDS metric, we categorized neurons into three distinct functional groups: regret neurons, non-regret neurons, and dual neurons.

Hanqi Yan, Xiangxiang Cui, Lu Yin et al.

Humans experience the world through multiple modalities, such as, vision, language, and speech, making it natural to explore the commonality and distinctions among them. In this work, we take a data-driven approach to address this question by analyzing interpretable, monosemantic features extracted from deep multimodal models. Specifically, we investigate CLIP, a prominent visual-language representation model trained on massive image-text pairs. Building on prior research in single-modal interpretability, we develop a set of multi-modal interpretability tools and measures designed to disentangle and analyze features learned from CLIP. Specifically, we introduce the Modality Dominance Score (MDS) to attribute each CLIP feature to a specific modality. We then map CLIP features into a more interpretable space, enabling us to categorize them into three distinct classes: vision features (single-modal), language features (single-modal), and visual-language features (cross-modal). Interestingly, this data-driven categorization closely aligns with human intuitive understandings of different modalities. We further show that this modality decomposition can benefit multiple downstream tasks, including reducing bias in gender detection, generating cross-modal adversarial examples, and enabling modal-specific feature control in text-to-image generation. These results indicate that large-scale multimodal models, when equipped with task-agnostic interpretability tools, can offer valuable insights into the relationships between different data modalities.