Joseph Shaw

Pouria Mortezaagha, Joseph Shaw, Bowen Sun et al.

Biomedical evidence synthesis relies on accurate extraction of methodological, laboratory, and outcome variables from full-text research articles, yet these variables are embedded in complex scientific PDFs that make manual abstraction time-consuming and difficult to scale. Existing document AI systems remain limited by OCR errors, long-document fragmentation, constrained throughput, and insufficient auditability for high-stakes synthesis. We present a schema-constrained AI extraction system that transforms full-text biomedical PDFs into structured, analysis-ready records by explicitly restricting model inference through typed schemas, controlled vocabularies, and evidence-gated decisions. Documents are ingested using resume-aware hashing, partitioned into caption-aware page-level chunks, and processed asynchronously under explicit concurrency controls. Chunk-level outputs are deterministically merged into study-level records using conflict-aware consolidation, set-based aggregation, and sentence-level provenance to support traceability and post-hoc audit. Evaluated on a corpus of studies on direct oral anticoagulant level measurement, the pipeline processed all documents without manual intervention, maintained stable throughput under service constraints, and exhibited strong internal consistency across document chunks. Iterative schema refinement substantially improved extraction fidelity for synthesis-critical variables, including assay classification, outcome definitions, follow-up duration, and timing of measurement. These results demonstrate that schema-constrained, provenance-aware extraction enables scalable and auditable transformation of heterogeneous scientific PDFs into structured evidence, aligning modern document AI with the transparency and reliability requirements of biomedical evidence synthesis.

Giorgio Morales, John Sheppard, Riley Logan et al.

In recent years, Hyperspectral Imaging (HSI) has become a powerful source for reliable data in applications such as remote sensing, agriculture, and biomedicine. However, hyperspectral images are highly data-dense and often benefit from methods to reduce the number of spectral bands while retaining the most useful information for a specific application. We propose a novel band selection method to select a reduced set of wavelengths, obtained from an HSI system in the context of image classification. Our approach consists of two main steps: the first utilizes a filter-based approach to find relevant spectral bands based on a collinearity analysis between a band and its neighbors. This analysis helps to remove redundant bands and dramatically reduces the search space. The second step applies a wrapper-based approach to select bands from the reduced set based on their information entropy values, and trains a compact Convolutional Neural Network (CNN) to evaluate the performance of the current selection. We present classification results obtained from our method and compare them to other feature selection methods on two hyperspectral image datasets. Additionally, we use the original hyperspectral data cube to simulate the process of using actual filters in a multispectral imager. We show that our method produces more suitable results for a multispectral sensor design.