Satoshi Endo

Cedric Donié, Marie K. Reumann, Tony Hartung et al.

Bone non-union is among the most severe complications associated with trauma surgery, occurring in 10-30% of cases after long bone fractures. Treating non-unions requires a high level of surgical expertise and often involves multiple revision surgeries, sometimes even leading to amputation. Thus, more accurate prognosis is crucial for patient well-being. Recent advances in machine learning (ML) hold promise for developing models to predict non-union healing, even when working with smaller datasets, a commonly encountered challenge in clinical domains. To demonstrate the effectiveness of ML in identifying candidates at risk of failed non-union healing, we applied three ML models (logistic regression, support vector machine, and XGBoost) to the clinical dataset TRUFFLE, which includes 797 patients with long bone non-union. The models provided prediction results with 70% sensitivity, and the specificities of 66% (XGBoost), 49% (support vector machine), and 43% (logistic regression). These findings offer valuable clinical insights because they enable early identification of patients at risk of failed non-union healing after the initial surgical revision treatment protocol.

Muriel Lang, Franz M. J. Pfister, Jakob Fröhner et al.

The assessment of Parkinson's disease (PD) poses a significant challenge as it is influenced by various factors which lead to a complex and fluctuating symptom manifestation. Thus, a frequent and objective PD assessment is highly valuable for effective health management of people with Parkinson's disease (PwP). Here, we propose a method for monitoring PwP by stochastically modeling the relationships between their wrist movements during unscripted daily activities and corresponding annotations about clinical displays of movement abnormalities. We approach the estimation of PD motor signs by independently modeling and hierarchically stacking Gaussian process models for three classes of commonly observed movement abnormalities in PwP including tremor, (non-tremulous) bradykinesia, and (non-tremulous) dyskinesia. We use clinically adopted severity measures as annotations for training the models, thus allowing our multi-layer Gaussian process prediction models to estimate not only their presence but also their severities. The experimental validation of our approach demonstrates strong agreement of the model predictions with these PD annotations. Our results show the proposed method produces promising results in objective monitoring of movement abnormalities of PD in the presence of arbitrary and unknown voluntary motions, and makes an important step towards continuous monitoring of PD in the home environment.

Terry Taewoong Um, Franz Michael Josef Pfister, Daniel Christian Pichler et al.

Parkinson's Disease (PD) is characterized by disorders in motor function such as freezing of gait, rest tremor, rigidity, and slowed and hyposcaled movements. Medication with dopaminergic medication may alleviate those motor symptoms, however, side-effects may include uncontrolled movements, known as dyskinesia. In this paper, an automatic PD motor-state assessment in free-living conditions is proposed using an accelerometer in a wrist-worn wearable sensor. In particular, an ensemble of convolutional neural networks (CNNs) is applied to capture the large variability of daily-living activities and overcome the dissimilarity between training and test patients due to the inter-patient variability. In addition, class activation map (CAM), a visualization technique for CNNs, is applied for providing an interpretation of the results.

Muriel Lang, Satoshi Endo, Oliver Dunkley et al.

A robotic system which approximates the user intention and appropriate complimentary motion is critical for successful human-robot interaction. %While the existing wearable sensors can monitor human movements in real-time, prediction of human movement is a significant challenge due to its highly non-linear motions optimised through the redundancy in the degrees of freedom. Here, we demonstrate robustness of the Gaussian Process (GP) clustered with a stochastic classification technique for trajectory prediction using an object handover scenario. By parametrising real 6D hand movements during human-human object handover using dual quaternions, variations of handover configurations were classified in real-time and then the remaining hand trajectory was predicted using the GP. The results highlights that our method can classify the handover configuration at an average of $43.4\%$ of the trajectory and the final hand configuration can be predicted within the normal variation of human movement. In conclusion, we demonstrate that GPs combined with a stochastic classification technique is a robust tool for proactively estimating human motions for human-robot interaction.