Wenjie Zhao

Chunze Yang, Qidong Liu, Wenjie Zhao et al.

Whole-slide image visual question answering (WSI-VQA) frames pathology as an extreme-context search problem: to answer a free-form clinical query, a system must first navigate a gigapixel slide under a strict inspection budget to locate sparse, high-resolution evidence. Existing approaches largely fall into two paradigms: i) supervised pathology multimodal large language models (MLLMs) and agents can absorb localization and reasoning into learned modules, but they often couple navigation to task-specific supervision and retraining, limiting their practicality; ii) training-free pathology agents avoid this cost by keeping core models frozen, but often follow a question-first design, constructing the initial candidate set mainly from query-conditioned relevance. This can miss decisive morphology that is not named in the question, and force heavier inference-time scaffolding. To address this challenge, we introduce PathNavigate, a training-free pathology agent built around a scan-search-readout routine. Before question matching, PathNavigate scans the current slide at low magnification with a shared online memory module over frozen pathology features, producing a slide-specific surprise field that marks an abnormal-region pool. It then applies question-conditioned PLIP relevance only within this pool to select high-magnification search targets. Finally, it extracts local high-magnification evidence and answers with a frozen perceptor-adjudicator stack, using the same online memory as slide-level context. Experiments on WSI-VQA and SlideBench-BCNB show that the proposed scan-search-readout design improves answer accuracy and yields more interpretable evidence-selection trajectories with higher efficiency.The code is available online.

Jiusong Ge, Yingkang Zhan, Wenjie Zhao et al.

Traditional whole slide image (WSI) analysis methods typically rely on the multiple instance learning (MIL) paradigm, which extracts patch-level features at high magnification and aggregates them for slide-level prediction. However, such exhaustive patch-level processing is computationally expensive, severely limiting the efficiency and scalability of WSI analysis. To address this challenge, we propose PathCTM (a Pathology-oriented Continuous Thought Model) that enables token-efficient scale-space continuous reasoning for gigapixel WSIs. PathCTM formulates diagnostic inference as a dynamic sequential information pursuit. It progressively transitions from low-magnification global to high-magnification local inspection, and adaptively terminates inference when sufficient evidence is gathered to effectively bound decision uncertainty. Specifically, it uses conditional computation for dynamic scale switching with attention-guided region pruning, coupled with confidence-aware early stopping. Extensive experiments demonstrate that, compared with standard MIL-based methods, PathCTM reduces the number of required image patches by 95.95% and shortens inference time by approximately 95.62%, while maintaining AUC without degradation. Code is available at https://github.com/JSGe-AI/PathCTM.

Wenjie Zhao, Jia Li, Xin Dong et al.

Semantic segmentation models, while effective for in-distribution categories, face challenges in real-world deployment due to encountering out-of-distribution (OoD) objects. Detecting these OoD objects is crucial for safety-critical applications. Existing methods rely on anomaly scores, but choosing a suitable threshold for generating masks presents difficulties and can lead to fragmentation and inaccuracy. This paper introduces a method to convert anomaly \textbf{S}core \textbf{T}o segmentation \textbf{M}ask, called S2M, a simple and effective framework for OoD detection in semantic segmentation. Unlike assigning anomaly scores to pixels, S2M directly segments the entire OoD object. By transforming anomaly scores into prompts for a promptable segmentation model, S2M eliminates the need for threshold selection. Extensive experiments demonstrate that S2M outperforms the state-of-the-art by approximately 20% in IoU and 40% in mean F1 score, on average, across various benchmarks including Fishyscapes, Segment-Me-If-You-Can, and RoadAnomaly datasets.

Ziyu Li, Wenjie Zhao, Asterios Katsifodimos et al.

The advent of Large Language Models (LLMs) provides an opportunity to change the way queries are processed, moving beyond the constraints of conventional SQL-based database systems. However, using an LLM to answer a prediction query is still challenging, since an external ML model has to be employed and inference has to be performed in order to provide an answer. This paper introduces LLM-PQA, a novel tool that addresses prediction queries formulated in natural language. LLM-PQA is the first to combine the capabilities of LLMs and retrieval-augmented mechanism for the needs of prediction queries by integrating data lakes and model zoos. This integration provides users with access to a vast spectrum of heterogeneous data and diverse ML models, facilitating dynamic prediction query answering. In addition, LLM-PQA can dynamically train models on demand, based on specific query requirements, ensuring reliable and relevant results even when no pre-trained model in a model zoo, available for the task.

Yuhang Liu, Wenjie Zhao, Yunhui Guo

Task Incremental Learning (TIL) is a specialized form of Continual Learning (CL) in which a model incrementally learns from non-stationary data streams. Existing TIL methodologies operate under the closed-world assumption, presuming that incoming data remains in-distribution (ID). However, in an open-world setting, incoming samples may originate from out-of-distribution (OOD) sources, with their task identities inherently unknown. Continually detecting OOD samples presents several challenges for current OOD detection methods: reliance on model outputs leads to excessive dependence on model performance, selecting suitable thresholds is difficult, hindering real-world deployment, and binary ID/OOD classification fails to provide task-level identification. To address these issues, we propose a novel continual OOD detection method called the Hierarchical Two-sample Tests (H2ST). H2ST eliminates the need for threshold selection through hypothesis testing and utilizes feature maps to better exploit model capabilities without excessive dependence on model performance. The proposed hierarchical architecture enables task-level detection with superior performance and lower overhead compared to non-hierarchical classifier two-sample tests. Extensive experiments and analysis validate the effectiveness of H2ST in open-world TIL scenarios and its superiority to the existing methods. Code is available at \href{https://github.com/YuhangLiuu/H2ST}{https://github.com/YuhangLiuu/H2ST}.

Wenjie Zhao, Jia Li, Xin Dong et al.

Open-set test-time adaptation (OSTTA) addresses the challenge of adapting models to new environments where out-of-distribution (OOD) samples coexist with in-distribution (ID) samples affected by distribution shifts. In such settings, covariate shift-for example, changes in weather conditions such as snow-can alter ID samples, reducing model reliability. Consequently, models must not only correctly classify covariate-shifted ID (csID) samples but also effectively reject covariate-shifted OOD (csOOD) samples. Entropy minimization is a common strategy in test-time adaptation to maintain ID performance under distribution shifts, while entropy maximization is widely applied to enhance OOD detection. Several studies have sought to combine these objectives to tackle the challenges of OSTTA. However, the intrinsic conflict between entropy minimization and maximization inevitably leads to a trade-off between csID classification and csOOD detection. In this paper, we first analyze the limitations of entropy maximization in OSTTA and then introduce an angular loss to regulate feature norm magnitudes, along with a feature-norm loss to suppress csOOD logits, thereby improving OOD detection. These objectives form ROSETTA, a $\underline{r}$obust $\underline{o}$pen-$\underline{se}$t $\underline{t}$est-$\underline{t}$ime $\underline{a}$daptation. Our method achieves strong OOD detection while maintaining high ID classification performance on CIFAR-10-C, CIFAR-100-C, Tiny-ImageNet-C and ImageNet-C. Furthermore, experiments on the Cityscapes validate the method's effectiveness in real-world semantic segmentation, and results on the HAC dataset demonstrate its applicability across different open-set TTA setups.

Yuhang Liu, Wenjie Zhao, Yunhui Guo

Selecting an appropriate pre-trained source model is a critical, yet computationally expensive, task in transfer learning. Model Transferability Estimation (MTE) methods address this by providing efficient proxy metrics to rank models without full fine-tuning. In practice, the choice of which MTE metric to use is often ad hoc or guided simply by a metric's average historical performance. However, we observe that the effectiveness of MTE metrics is highly task-dependent and no single metric is universally optimal across all target datasets. To address this gap, we introduce MetaRank, a meta-learning framework for automatic, task-aware MTE metric selection. We formulate metric selection as a learning-to-rank problem. Rather than relying on conventional meta-features, MetaRank encodes textual descriptions of both datasets and MTE metrics using a pretrained language model, embedding them into a shared semantic space. A meta-predictor is then trained offline on diverse meta-tasks to learn the intricate relationship between dataset characteristics and metric mechanisms, optimized with a listwise objective that prioritizes correctly ranking the top-performing metrics. During the subsequent online phase, MetaRank efficiently ranks the candidate MTE metrics for a new, unseen target dataset based on its textual description, enabling practitioners to select the most appropriate metric a priori. Extensive experiments across 11 pretrained models and 11 target datasets demonstrate the strong effectiveness of our approach.

Wenjie Zhao, Jia Li, Mingrui Liu et al.

``How long can I live and remain free of cancer?'' is often the first question a patient asks after receiving a cancer diagnosis and treatment. Accurate survival prediction helps alleviate psychological distress and supports risk stratification and personalized treatment planning. Recent survival prediction frameworks have shown strong performance using computed tomography (CT) images. However, variations in imaging acquisition introduce out-of-distribution (OOD) samples caused by covariate shifts that undermine model reliability. Despite this challenge, to our knowledge, no existing benchmark systematically studies OOD detection in cancer survival prediction. To address this gap, we introduce the Cancer sURvival bEnchmark for OOD Detection (CURE-OOD), the first benchmark for systematically evaluating OOD detection in survival prediction under controlled acquisition-induced distribution shifts. CURE-OOD defines scanner-parameter-based training, in-distribution (ID), and OOD test splits across four survival prediction tasks. Our experiments show that covariate shifts notably reduce survival prediction performance. It also shows that mainstream classification-oriented OOD detectors can fail in survival prediction. Finally, we include HazardDev as a simple survival-aware reference baseline for OOD detection. CURE-OOD enables systematic analysis of how distribution shifts affect both downstream survival performance and OOD detectability.

Jia Li, Wenjie Zhao, Ziru Huang et al.

Unlike traditional visual segmentation, audio-visual segmentation (AVS) requires the model not only to identify and segment objects but also to determine whether they are sound sources. Recent AVS approaches, leveraging transformer architectures and powerful foundation models like SAM, have achieved impressive performance on standard benchmarks. Yet, an important question remains: Do these models genuinely integrate audio-visual cues to segment sounding objects? In this paper, we systematically investigate this issue in the context of robust AVS. Our study reveals a fundamental bias in current methods: they tend to generate segmentation masks based predominantly on visual salience, irrespective of the audio context. This bias results in unreliable predictions when sounds are absent or irrelevant. To address this challenge, we introduce AVSBench-Robust, a comprehensive benchmark incorporating diverse negative audio scenarios including silence, ambient noise, and off-screen sounds. We also propose a simple yet effective approach combining balanced training with negative samples and classifier-guided similarity learning. Our extensive experiments show that state-of-theart AVS methods consistently fail under negative audio conditions, demonstrating the prevalence of visual bias. In contrast, our approach achieves remarkable improvements in both standard metrics and robustness measures, maintaining near-perfect false positive rates while preserving highquality segmentation performance.

Xiaokun Liu, Sayedmohammadreza Rastegari, Yijun Huang et al.

In cancer therapeutics, protein-metal binding mechanisms critically govern the pharmacokinetics and targeting efficacy of drugs, thereby fundamentally shaping the rational design of anticancer metallodrugs. While conventional laboratory methods used to study such mechanisms are often costly, low throughput, and limited in capturing dynamic biological processes, machine learning (ML) has emerged as a promising alternative. Despite increasing efforts to develop protein-metal binding datasets and ML algorithms, the application of ML in tumor protein-metal binding remains limited. Key challenges include a shortage of high-quality, tumor-specific datasets, insufficient consideration of multiple data modalities, and the complexity of interpreting results due to the ''black box'' nature of complex ML models. This paper summarizes recent progress and ongoing challenges in using ML to predict tumor protein-metal binding, focusing on data, modeling, and interpretability. We present multimodal protein-metal binding datasets and outline strategies for acquiring, curating, and preprocessing them for training ML models. Moreover, we explore the complementary value provided by different data modalities and examine methods for their integration. We also review approaches for improving model interpretability to support more trustworthy decisions in cancer research. Finally, we offer our perspective on research opportunities and propose strategies to address the scarcity of tumor protein data and the limited number of predictive models for tumor protein-metal binding. We also highlight two promising directions for effective metal-based drug design: integrating protein-protein interaction data to provide structural insights into metal-binding events and predicting structural changes in tumor proteins after metal binding.

Jia Li, Wenjie Zhao, Shijian Deng et al.

Online egocentric gaze estimation predicts where a camera wearer is looking from first-person video using only past and current frames, a task essential for augmented reality and assistive technologies. Unlike third-person gaze estimation, this setting lacks explicit head or eye signals, requiring models to infer current visual attention from sparse, indirect cues such as hand-object interactions and salient scene content. We observe that gaze exhibits strong temporal continuity during goal-directed activities: knowing where a person looked recently provides a powerful prior for predicting where they look next. Inspired by vision-conditioned autoregressive decoding in vision-language models, we propose ARGaze, which reformulates gaze estimation as sequential prediction: at each timestep, a transformer decoder predicts current gaze by conditioning on (i) current visual features and (ii) a fixed-length Gaze Context Window of recent gaze target estimates. This design enforces causality and enables bounded-resource streaming inference. We achieve state-of-the-art performance across multiple egocentric benchmarks under online evaluation, with extensive ablations validating that autoregressive modeling with bounded gaze history is critical for robust prediction. We will release our source code and pre-trained models.

Wenjie Zhao, Jia Li, Yunhui Guo

Out-of-distribution (OoD) detection and segmentation have attracted growing attention as concerns about AI security rise. Conventional OoD detection methods identify the existence of OoD objects but lack spatial localization, limiting their usefulness in downstream tasks. OoD segmentation addresses this limitation by localizing anomalous objects at pixel-level granularity. This capability is crucial for safety-critical applications such as autonomous driving, where perception modules must not only detect but also precisely segment OoD objects, enabling targeted control actions and enhancing overall system robustness. In this survey, we group current OoD segmentation approaches into four categories: (i) test-time OoD segmentation, (ii) outlier exposure for supervised training, (iii) reconstruction-based methods, (iv) and approaches that leverage powerful models. We systematically review recent advances in OoD segmentation for autonomous-driving scenarios, identify emerging challenges, and discuss promising future research directions.

Weibin Jia, Wenjie Zhao, Zhihuan Song et al.

Due to possibly changing pose of a movable object and nonholonomic constraint of a differential-drive robot, it is challenging to design an object servoing scheme for the differential-drive robot to asymptotically park at a predefined relative pose to the movable object. In this paper, a novel object servoing scheme is designed for the differential-drive robots. Each on-line relative pose is first estimated by using feature points of the moveable object and it serves as the input of an object servoing friendly parking controller. The linear velocity and angular velocity are then determined by the parking controller. Experimental results validate the performance of the proposed object servoing scheme. Due to its low on-line computational cost, the proposed scheme can be applied for last mile delivery of differential-drive robots to movable objects.

Yu Chen, Jie Chen, Ganesh Krishnamurthi et al.

Due to the high variability of the traffic in the radio access network (RAN), fixed network configurations are not flexible enough to achieve optimal performance. Our vendors provide several settings of the eNodeB to optimize the RAN performance, such as media access control scheduler, loading balance, etc. But the detailed mechanisms of the eNodeB configurations are usually very complicated and not disclosed, not to mention the large key performance indicators (KPIs) space needed to be considered. These make constructing a simulator, offline tuning, or rule-based solutions difficult. We aim to build an intelligent controller without strong assumption or domain knowledge about the RAN and can run 24/7 without supervision. To achieve this goal, we first build a closed-loop control testbed RAN in a lab environment with one eNodeB provided by one of the largest wireless vendors and four smartphones. Next, we build a double Q network agent trained with the live feedback of the key performance indicators from the RAN. Our work proved the effectiveness of applying deep reinforcement learning to improve network performance in a real RAN network environment.