Jian Geng

Kaixing Long, Danyi Weng, Yun Mi et al.

Constructing a multi-modal automatic classification model based on three types of renal biopsy images can assist pathologists in glomerular multi-disease identification. However, the substantial scale difference between transmission electron microscopy (TEM) image features at the nanoscale and optical microscopy (OM) or immunofluorescence microscopy (IM) images at the microscale poses a challenge for existing multi-modal and multi-scale models in achieving effective feature fusion and improving classification accuracy. To address this issue, we propose a cross-modal ultra-scale learning network (CMUS-Net) for the auxiliary diagnosis of multiple glomerular diseases. CMUS-Net utilizes multiple ultrastructural information to bridge the scale difference between nanometer and micrometer images. Specifically, we introduce a sparse multi-instance learning module to aggregate features from TEM images. Furthermore, we design a cross-modal scale attention module to facilitate feature interaction, enhancing pathological semantic information. Finally, multiple loss functions are combined, allowing the model to weigh the importance among different modalities and achieve precise classification of glomerular diseases. Our method follows the conventional process of renal biopsy pathology diagnosis and, for the first time, performs automatic classification of multiple glomerular diseases including IgA nephropathy (IgAN), membranous nephropathy (MN), and lupus nephritis (LN) based on images from three modalities and two scales. On an in-house dataset, CMUS-Net achieves an ACC of 95.37+/-2.41%, an AUC of 99.05+/-0.53%, and an F1-score of 95.32+/-2.41%. Extensive experiments demonstrate that CMUS-Net outperforms other well-known multi-modal or multi-scale methods and show its generalization capability in staging MN. Code is available at https://github.com/SMU-GL-Group/MultiModal_lkx/tree/main.

Jieyun Tan, Shuo Liu, Guibin Zhang et al.

Automated detection of electron dense deposits (EDD) in glomerular disease is hindered by the scarcity of high-quality labeled data. While crowdsourcing reduces annotation cost, it introduces label noise. We propose an active label cleaning method to efficiently denoise crowdsourced datasets. Our approach uses active learning to select the most valuable noisy samples for expert re-annotation, building high-accuracy cleaning models. A Label Selection Module leverages discrepancies between crowdsourced labels and model predictions for both sample selection and instance-level noise grading. Experiments show our method achieves 67.18% AP\textsubscript{50} on a private dataset, an 18.83% improvement over training on noisy labels. This performance reaches 95.79% of that with full expert annotation while reducing annotation cost by 73.30%. The method provides a practical, cost-effective solution for developing reliable medical AI with limited expert resources.

Zhentai Zhang, Danyi Weng, Guibin Zhang et al.

Background and Objective: To address the inability of single-model architectures to perform simultaneous analysis of complex glomerular ultrastructures, we developed Glo-UMF, a unified multi-model framework integrating segmentation, classification, and detection to systematically quantify key ultrastructural features. Methods: Glo-UMF decouples quantification tasks by constructing three dedicated deep models: an ultrastructure segmentation model, a glomerular filtration barrier (GFB) region classification model, and an electron-dense deposits (EDD) detection model. Their outputs are integrated through a post-processing workflow with adaptive GFB cropping and measurement location screening, enhancing measurement reliability and providing comprehensive quantitative results that overcome the limitations of traditional grading. Results: Trained on 372 electron microscopy images, Glo-UMF enables simultaneous quantification of glomerular basement membrane (GBM) thickness, the degree of foot process effacement (FPE), and EDD location. In 115 test cases spanning 9 renal pathological types, the automated quantification results showed strong agreement with pathological reports, with an average processing time of 4.23$\pm$0.48 seconds per case on a CPU environment. Conclusions: The modular design of Glo-UMF allows for flexible extensibility, supporting the joint quantification of multiple features. This framework ensures robust generalization and clinical applicability, demonstrating significant potential as an efficient auxiliary tool in glomerular pathological analysis.