Max Talanov

Szymon Mamoń, Max Talanov, Alessandro Crimi

As the prevalence of Alzheimer's disease (AD) rises, improving mechanistic insight from non-invasive biomarkers is increasingly critical. Recent work suggests that circuit-level brain alterations manifest as changes in electroencephalography (EEG) spectral features detectable by machine learning. However, conventional deep learning approaches for EEG-based AD detection are computationally intensive and mechanistically opaque. Spiking neural networks (SNNs) offer a biologically plausible and energy-efficient alternative, yet their application to AD diagnosis remains largely unexplored. We propose a neuro-bridge framework that links data-driven learning with minimal, biophysically grounded simulations, enabling bidirectional interpretation between machine learning signatures and circuit-level mechanisms in AD. Using resting-state clinical EEG, we train an SNN classifier that achieves competitive performance (AUC = 0.839) and identifies the aperiodic 1/f slope as a key discriminative marker. The 1/f slope reflects excitation-inhibition balance. To interpret this mechanistically, we construct spiking network simulations in which inhibitory-to-excitatory synaptic ratios are systematically varied to emulate healthy, mild cognitive impairment, and AD-like states. Using both membrane potential-based and synaptic current-based EEG proxies, we reproduce empirical spectral slowing and altered alpha organization. Incorporating empirical functional connectivity priors into multi-subnetwork simulations further enhances spectral differentiation, demonstrating that large-scale network topology constrains EEG signatures more strongly than excitation-inhibition balance alone. Overall, this neuro-bridge approach connects SNN-based classification with interpretable circuit simulations, advancing mechanistic understanding of EEG biomarkers while enabling scalable, explainable AD detection.

Lukas Breitwieser, Roman Bauer, Alberto Di Meglio et al.

Computer simulations have become a very powerful tool for scientific research. In order to facilitate research in computational biology, the BioDynaMo project aims at a general platform for biological computer simulations, which should be executable on hybrid cloud computing systems. This paper describes challenges and lessons learnt during the early stages of the software development process, in the context of implementation issues and the international nature of the collaboration.

Leonard Johard, Lukas Breitwieser, Alberto Di Meglio et al.

This paper is a brief update on developments in the BioDynaMo project, a new platform for computer simulations for biological research. We will discuss the new capabilities of the simulator, important new concepts simulation methodology as well as its numerous applications to the computational biology and nanoscience communities.

Alexander Tchitchigin, Max Talanov, Larisa Safina et al.

In this paper we present the next step in our approach to neurobiologically plausible implementation of emotional reactions and behaviors for real-time autonomous robotic systems. The working metaphor we use is the "day" and the "night" phases of mammalian life. During the "day phase" a robotic system stores the inbound information and is controlled by a light-weight rule-based system in real time. In contrast to that, during the "night phase" information that has been stored is transferred to a supercomputing system to update the realistic neural network: emotional and behavioral strategies.

Roman Bauer, Lukas Breitwieser, Alberto Di Meglio et al.

Computer simulations have become a very powerful tool for scientific research. Given the vast complexity that comes with many open scientific questions, a purely analytical or experimental approach is often not viable. For example, biological systems (such as the human brain) comprise an extremely complex organization and heterogeneous interactions across different spatial and temporal scales. In order to facilitate research on such problems, the BioDynaMo project (\url{https://biodynamo.web.cern.ch/}) aims at a general platform for computer simulations for biological research. Since the scientific investigations require extensive computer resources, this platform should be executable on hybrid cloud computing systems, allowing for the efficient use of state-of-the-art computing technology. This paper describes challenges during the early stages of the software development process. In particular, we describe issues regarding the implementation and the highly interdisciplinary as well as international nature of the collaboration. Moreover, we explain the methodologies, the approach, and the lessons learnt by the team during these first stages.

Michael W. Bridges, Salvatore Distefano, Manuel Mazzara et al.

This paper proposes a model which aim is providing a more coherent framework for agents design. We identify three closely related anthropo-centered domains working on separate functional levels. Abstracting from human physiology, psychology, and philosophy we create the $P^3$ model to be used as a multi-tier approach to deal with complex class of problems. The three layers identified in this model have been named PhysioComputing, MindComputing, and MetaComputing. Several instantiations of this model are finally presented related to different IT areas such as artificial intelligence, distributed computing, software and service engineering.

Jordi Vallverdú, Max Talanov, Salvatore Distefano et al.

In this paper we present a new neurobiologically-inspired affective cognitive architecture: NEUCOGAR (NEUromodulating COGnitive ARchitecture). The objective of NEUCOGAR is the identification of a mapping from the influence of serotonin, dopamine and noradrenaline to the computing processes based on Von Neuman's architecture, in order to implement affective phenomena which can operate on the Turing's machine model. As basis of the modeling we use and extend the Lövheim Cube of Emotion with parameters of the Von Neumann architecture. Validation is conducted via simulation on a computing system of dopamine neuromodulation and its effects on the Cortex. In the experimental phase of the project, the increase of computing power and storage redistribution due to emotion stimulus modulated by the dopamine system, confirmed the soundness of the model.

Alexander Tchitchigin, Max Talanov, Larisa Safina et al.

In this position paper we present a novel approach to neurobiologically plausible implementation of emotional reactions and behaviors for real-time autonomous robotic systems. The working metaphor we use is the "day" and "night" phases of mammalian life. During the "day" phase a robotic system stores the inbound information and is controlled by a light-weight rule-based system in real time. In contrast to that, during the "night" phase the stored information is been transferred to the supercomputing system to update the realistic neural network: emotional and behavioral strategies.