Chenkai Guo

Chenkai Guo, Yikai Zhu, Jing Yangum et al.

By incorporating spatial location information, spatial-transcriptomics clustering yields more comprehensive insights into cell subpopulation identification. Despite recent progress, existing methods have at least two limitations: (i) topological learning typically considers only representations of individual cells or their interaction graphs; however, spatial transcriptomic profiles are often noisy, making these approaches vulnerable to low-quality topological signals, and (ii) insufficient modeling of spatial neighborhood information leads to low-quality spatial embeddings. To address these limitations, we propose SPHENIC, a novel Spatial Persistent Homology Enhanced Neighborhood Integrative Clustering method. Specifically, SPHENIC incorporates invariant topological features into the clustering network to achieve stable representation learning. Additionally, to construct high-quality spatial embeddings that reflect the true cellular distribution, we design the Spatial Constraint and Distribution Optimization Module (SCDOM). This module increases the similarity between a cell's embedding and those of its spatial neighbors, decreases similarity with non-neighboring cells, and thereby produces clustering-friendly spatial embeddings. Extensive experiments on 14 benchmark spatial transcriptomic slices demonstrate that SPHENIC achieves superior performance on the spatial clustering task, outperforming existing state-of-the-art methods by 3.31%-6.54% over the best alternative.

Yanfeng Wu, Chenkai Guo, Junan Zhao et al.

The convolutional neural network (CNN) based approaches have shown great success for speaker verification (SV) tasks, where modeling long temporal context and reducing information loss of speaker characteristics are two important challenges significantly affecting the verification performance. Previous works have introduced dilated convolution and multi-scale aggregation methods to address above challenges. However, such methods are also hard to make full use of some valuable information, which make it difficult to substantially improve the verification performance. To address above issues, we construct a novel CNN-based architecture for SV, called RSKNet-MTSP, where a residual selective kernel block (RSKBlock) and a multiple time-scale statistics pooling (MTSP) module are first proposed. The RSKNet-MTSP can capture both long temporal context and neighbouring information, and gather more speaker-discriminative information from multi-scale features. In order to design a portable model for real applications with limited resources, we then present a lightweight version of RSKNet-MTSP, namely RSKNet-MTSP-L, which employs a combination technique associating the depthwise separable convolutions with low-rank factorization of weight matrices. Extensive experiments are conducted on two public SV datasets, VoxCeleb and Speaker in the Wild (SITW). The results demonstrate that 1) RSKNet-MTSP outperforms the state-of-the-art deep embedding architectures by at least 9%-26% in all test sets. 2) RSKNet-MTSP-L achieves competitive performance compared with baseline models with 17%-39% less network parameters. The ablation experiments further illustrate that our proposed approaches can achieve substantial improvement over prior methods.