Linyi Han

Cihan Ruan, Lebin Zhou, Rongduo Han et al.

DNA storage has matured from concept to practical stage, yet its integration with neural compression pipelines remains inefficient. Early DNA encoders applied redundancy-heavy constraint layers atop raw binary data - workable but primitive. Recent neural codecs compress data into learned latent representations with rich statistical structure, yet still convert these latents to DNA via naive binary-to-quaternary transcoding, discarding the entropy model's optimization. This mismatch undermines compression efficiency and complicates the encoding stack. A plug-in module that collapses latent compression and DNA encoding into a single step. SCONE performs quaternary arithmetic coding directly on the latent space in DNA bases. Its Constraint-Aware Adaptive Coding module dynamically steers the entropy encoder's learned probability distribution to enforce biochemical constraints - Guanine-Cytosine (GC) balance and homopolymer suppression - deterministically during encoding, eliminating post-hoc correction. The design preserves full reversibility and exploits the hyperprior model's learned priors without modification. Experiments show SCONE achieves near-perfect constraint satisfaction with negligible computational overhead (<2% latency), establishing a latent-agnostic interface for end-to-end DNA-compatible learned codecs.

Cihan Ruan, Lebin Zhou, Bingqing Zhao et al.

DNA-based storage has emerged as a promising approach to the global data crisis, offering molecular-scale density and millennial-scale stability at low maintenance cost. Over the past decade, substantial progress has been made in storing text, images, and files in DNA -- yet video remains an open challenge. The difficulty is not merely technical: effective video DNA storage requires co-designing compression and molecular encoding from the ground up, a challenge that sits at the intersection of two fields that have largely evolved independently. In this work, we present HELIX, the first end-to-end neural network jointly optimizing video compression and DNA encoding -- prior approaches treat the two stages independently, leaving biochemical constraints and compression objectives fundamentally misaligned. Our key insight: token-based representations naturally align with DNA's quaternary alphabet -- discrete semantic units map directly to ATCG bases. We introduce TK-SCONE (Token-Kronecker Structured Constraint-Optimized Neural Encoding), which achieves 1.91 bits per nucleotide through Kronecker-structured mixing that breaks spatial correlations and FSM-based mapping that guarantees biochemical constraints. Unlike two-stage approaches, HELIX learns token distributions simultaneously optimized for visual quality, prediction under masking, and DNA synthesis efficiency. This work demonstrates for the first time that learned compression and molecular storage converge naturally at token representations -- suggesting a new paradigm where neural video codecs are designed for biological substrates from the ground up.

Qiming Yuan, Linyi Han, Nam Ling et al.

People increasingly turn to large language models (LLMs) to interpret ambiguous social situations: a delayed text reply, an unusually cold supervisor, a teacher's mixed signals, or a boundary-crossing friend. Yet in many such cases, no stable interpretation can be verified from the available evidence alone. We study how LLMs respond to these situations across four domains: early-stage romantic relationships, teacher--student dynamics, workplace hierarchies, and ambiguous friendships. Across 72 responses from GPT, Claude, and Gemini, only 9 (12.5\%) genuinely preserved uncertainty. The remaining 87.5% produced interpretive closure through recurring pathways including narrative alignment, narrative reversal, normative advice under uncertainty, and hedged language that still supported a single conclusion. We further find that narrator perspective shapes the path to closure: first-person accounts more often elicited alignment, while third-person accounts invited more detached interpretation, even when the underlying situation remained comparable. Together, these findings show that LLMs do not simply assist interpersonal sensemaking; they tend to resolve ambiguity into coherent and actionable narratives. These results suggest that the central risk is not only that LLMs may misinterpret social situations, but that they may make unresolved situations feel prematurely settled. We frame this tendency as a design challenge for uncertainty-preserving social AI.