Milan Gautam

Milan Gautam, Ning Dai, Tianshuo Zhou et al.

RNA design, the task of finding a sequence that folds into a target secondary structure, has broad biological and biomedical impact but remains computationally challenging due to the exponentially large sequence space and exponentially many competing folds. Traditional approaches treat it as an optimization problem, relying on per-instance heuristics or constraint-based search. We instead reframe RNA design as conditional sequence generation and introduce a reusable neural approximator, instantiated as an autoregressive language model (LM), that maps target structures directly to sequences. We first train our model in a supervised setting on random-induced structure-sequence pairs, and then use reinforcement learning (RL) to optimize end-to-end metrics. We also propose methods to select a small subset for RL that greatly improves RL efficiency and quality. Across four datasets, our approach outperforms state-of-the-art systems on key metrics such as Boltzmann probability while being 1.7x faster, establishing conditional LM generation as a scalable, task-agnostic alternative to per-instance optimization for RNA design. Our code and data are available at https://github.com/KuNyaa/RNA-Design-LM.

Zetian Wu, Bowen Xie, Wuyang Meng et al.

The field of sign language translation has witnessed significant progress in the translation between sign and spoken languages, but the translation between sign languages remains largely unexplored and out of reach. The latter can help 1.5 billion deaf and hard-of-hearing (DHH) people worldwide communicate across language barriers without relying on hearing interpreters or written-language fluency. The cascade approach composing separate sign-to-text, text-to-text, and text-to-sign systems suffers from error propagation and extra latency as well as the loss of information unique in the visual modality. We aim to develop direct sign-to-sign translation. However, a large-scale open-domain parallel corpus has not been curated between sign languages. To enable direct translation between sign language utterances, we use back-translation to produce synthetic sign-sign pairs from unaligned individual language utterance-sign corpora. Using this data, we jointly train a single MBART-based model for both text->sign (T2S) and sign->sign (S2S). On synthetically generated paired sets between American Sign Language (ASL), Chinese Sign Language (CSL), and German Sign Language (DGS), our direct S2S method outperforms the cascaded baseline on geometric sign error metrics (20% lower DTW-aligned MPJPE) and language matching metrics after predicted sign utterances are translated back to sentences (50% high BLEU-4) while achieving a roughly 2.3* speedup. On a small set of pre-existing cross-lingual sign data, we find similar improvements for our proposed method.