Abdul Wahab

Ehtisham Fazal, Muhammad Sohail Ibrahim, Seongyong Park et al.

Cancer is one of the most challenging diseases because of its complexity, variability, and diversity of causes. It has been one of the major research topics over the past decades, yet it is still poorly understood. To this end, multifaceted therapeutic frameworks are indispensable. \emph{Anticancer peptides} (ACPs) are the most promising treatment option, but their large-scale identification and synthesis require reliable prediction methods, which is still a problem. In this paper, we present an intuitive classification strategy that differs from the traditional \emph{black box} method and is based on the well-known statistical theory of \emph{sparse-representation classification} (SRC). Specifically, we create over-complete dictionary matrices by embedding the \emph{composition of the K-spaced amino acid pairs} (CKSAAP). Unlike the traditional SRC frameworks, we use an efficient \emph{matching pursuit} solver instead of the computationally expensive \emph{basis pursuit} solver in this strategy. Furthermore, the \emph{kernel principal component analysis} (KPCA) is employed to cope with non-linearity and dimension reduction of the feature space whereas the \emph{synthetic minority oversampling technique} (SMOTE) is used to balance the dictionary. The proposed method is evaluated on two benchmark datasets for well-known statistical parameters and is found to outperform the existing methods. The results show the highest sensitivity with the most balanced accuracy, which might be beneficial in understanding structural and chemical aspects and developing new ACPs. The Google-Colab implementation of the proposed method is available at the author's GitHub page (\href{https://github.com/ehtisham-Fazal/ACP-Kernel-SRC}{https://github.com/ehtisham-fazal/ACP-Kernel-SRC}).

Jaejun Yoo, Younghoon Jung, Mikyoung Lim et al.

A robust algorithm is proposed to reconstruct the spatial support and the Lamé parameters of multiple inclusions in a homogeneous background elastic material using a few measurements of the displacement field over a finite collection of boundary points. The algorithm does not require any linearization or iterative update of Green's function but still allows very accurate reconstruction. The breakthrough comes from a novel interpretation of Lippmann-Schwinger type integral representation of the displacement field in terms of unknown densities having common sparse support on the location of inclusions. Accordingly, the proposed algorithm consists of a two-step approach. First, the localization problem is recast as a joint sparse recovery problem that renders the densities and the inclusion support simultaneously. Then, a noise robust constrained optimization problem is formulated for the reconstruction of elastic parameters. An efficient algorithm is designed for numerical implementation using the Multiple Sparse Bayesian Learning (M-SBL) for joint sparse recovery problem and the Constrained Split Augmented Lagrangian Shrinkage Algorithm (C-SALSA) for the constrained optimization problem. The efficacy of the proposed framework is manifested through extensive numerical simulations. To the best of our knowledge, this is the first algorithm tailored for parameter reconstruction problems in elastic media using highly under-sampled data in the sense of Nyquist rate.

Tasawar Abbas, Shujaat Khan, Muhammad Sajid et al.

The aim of this article is to present and rigorously analyze topological sensitivity based algorithms for detection of diametrically small inclusions in an isotropic homogeneous elastic formation using single and multiple measurements of the far-field scattering amplitudes. A $L^2-$cost functional is considered and a location indicator is constructed from its topological derivative. The performance of the indicator is analyzed in terms of the topological sensitivity for location detection and stability with respect to measurement and medium noises. It is established that the location indicator does not guarantee inclusion detection and achieves only a low resolution when there is mode-conversion in an elastic formation. Accordingly, a weighted location indicator is designed to tackle the mode-conversion phenomenon. It is substantiated that the weighted function renders the location of an inclusion stably with resolution as per Rayleigh criterion.

Abdul Wahab, Tariq Mahmood Khan, Shahzaib Iqbal et al.

Identification of suspects based on partial and smudged fingerprints, commonly referred to as fingermarks or latent fingerprints, presents a significant challenge in the field of fingerprint recognition. Although fixed-length embeddings have shown effectiveness in recognising rolled and slap fingerprints, the methods for matching latent fingerprints have primarily centred around local minutiae-based embeddings, failing to fully exploit global representations for matching purposes. Consequently, enhancing latent fingerprints becomes critical to ensuring robust identification for forensic investigations. Current approaches often prioritise restoring ridge patterns, overlooking the fine-macroeconomic details crucial for accurate fingerprint recognition. To address this, we propose a novel approach that uses generative adversary networks (GANs) to redefine Latent Fingerprint Enhancement (LFE) through a structured approach to fingerprint generation. By directly optimising the minutiae information during the generation process, the model produces enhanced latent fingerprints that exhibit exceptional fidelity to ground-truth instances. This leads to a significant improvement in identification performance. Our framework integrates minutiae locations and orientation fields, ensuring the preservation of both local and structural fingerprint features. Extensive evaluations conducted on two publicly available datasets demonstrate our method's dominance over existing state-of-the-art techniques, highlighting its potential to significantly enhance latent fingerprint recognition accuracy in forensic applications.

Elie Bretin, Lili Guadarrama Bustos, Abdul Wahab

In this work, we consider the problem of reconstructing a small anomaly in a viscoelastic medium from wave-field measurements. We choose Szabo's model to describe the viscoelastic properties of the medium. Expressing the ideal elastic field without any viscous effect in terms of the measured field in a viscous medium, we generalize the imaging procedures, such as time reversal, Kirchhoff Imaging and Back propagation, for an ideal medium to detect an anomaly in a visco-elastic medium from wave-field measurements.

Abdul Wahab, Tasawar Abbas, Naveed Ahmed et al.

In this article a topological sensitivity framework for far field detection of a diametrically small electromagnetic inclusion is established. The cases of single and multiple measurements of the electric far field scattering amplitude at a fixed frequency are taken into account. The performance of the algorithm is analyzed theoretically in terms of its resolution and sensitivity for locating an inclusion. The stability of the framework with respect to measurement and medium noises is discussed. Moreover, the quantitative results for signal-to-noise ratio are presented. A few numerical results are presented to illustrate the detection capabilities of the proposed framework with single and multiple measurements.

Muhammad Kamran Janjua, Abdul Wahab, Bahador Rashidi

In this work, we introduce a new perspective on comparative image assessment by representing an image pair as a structured composition of its regions. In contrast, existing methods focus on whole image analysis, while implicitly relying on region-level understanding. We extend the intra-image notion of a scene graph to inter-image, and propose a novel task of Distortion Graph (DG). DG treats paired images as a structured topology grounded in regions, and represents dense degradation information such as distortion type, severity, comparison and quality score in a compact interpretable graph structure. To realize the task of learning a distortion graph, we contribute (i) a region-level dataset, PandaSet, (ii) a benchmark suite, PandaBench, with varying region-level difficulty, and (iii) an efficient architecture, Panda, to generate distortion graphs. We demonstrate that PandaBench poses a significant challenge for state-of-the-art multimodal large language models (MLLMs) as they fail to understand region-level degradations even when fed with explicit region cues. We show that training on PandaSet or prompting with DG elicits region-wise distortion understanding, opening a new direction for fine-grained, structured pairwise image assessment.

Abdul Wahab, Raksha Kumaraswamy, Martha White

Optimistic value estimates provide one mechanism for directed exploration in reinforcement learning (RL). The agent acts greedily with respect to an estimate of the value plus what can be seen as a value bonus. The value bonus can be learned by estimating a value function on reward bonuses, propagating local uncertainties around rewards. However, this approach only increases the value bonus for an action retroactively, after seeing a higher reward bonus from that state and action. Such an approach does not encourage the agent to visit a state and action for the first time. In this work, we introduce an algorithm for exploration called Value Bonuses with Ensemble errors (VBE), that maintains an ensemble of random action-value functions (RQFs). VBE uses the errors in the estimation of these RQFs to design value bonuses that provide first-visit optimism and deep exploration. The key idea is to design the rewards for these RQFs in such a way that the value bonus can decrease to zero. We show that VBE outperforms Bootstrap DQN and two reward bonus approaches (RND and ACB) on several classic environments used to test exploration and provide demonstrative experiments that it can scale easily to more complex environments like Atari.

Shujaat Khan, Muhammad Usman, Abdul Wahab

Species living in the extreme cold environment fight against the harsh conditions using antifreeze proteins (AFPs), that manipulates the freezing mechanism of water in more than one way. This amazing nature of AFP turns out to be extremely useful in several industrial and medical applications. The lack of similarity in their structure and sequence makes their prediction an arduous task and identifying them experimentally in the wet-lab is time-consuming and expensive. In this research, we propose a computational framework for the prediction of AFPs which is essentially based on a sample-specific classification method using the sparse reconstruction. A linear model and an over-complete dictionary matrix of known AFPs are used to predict a sparse class-label vector that provides a sample-association score. Delta-rule is applied for the reconstruction of two pseudo-samples using lower and upper parts of the sample-association vector and based on the minimum recovery score, class labels are assigned. We compare our approach with contemporary methods on a standard dataset and the proposed method is found to outperform in terms of Balanced accuracy and Youden's index. The MATLAB implementation of the proposed method is available at the author's GitHub page (\{https://github.com/Shujaat123/AFP-SRC}{https://github.com/Shujaat123/AFP-SRC}).

Seongyong Park, Shujaat Khan, Abdul Wahab

Understanding E3 ligase and target substrate interactions are important for cell biology and therapeutic development. However, experimental identification of E3 target relationships is not an easy task due to the labor-intensive nature of the experiments. In this article, a sequence-based E3-target prediction model is proposed for the first time. The proposed framework utilizes composition of k-spaced amino acid pairs (CKSAAP) to learn the relationship between E3 ligases and their target protein. A class separable latent space encoding scheme is also devised that provides a compressed representation of feature space. A thorough ablation study is performed to identify an optimal gap size for CKSAAP and the number of latent variables that can represent the E3-target relationship successfully. The proposed scheme is evaluated on an independent dataset for a variety of standard quantitative measures. In particular, it achieves an average accuracy of $70.63\%$ on an independent dataset. The source code and datasets used in the study are available at the author's GitHub page (https://github.com/psychemistz/E3targetPred).

Abdul Wahab, Shujaat Khan, Imran Naseem et al.

Fractional learning algorithms are trending in signal processing and adaptive filtering recently. However, it is unclear whether the proclaimed superiority over conventional algorithms is well-grounded or is a myth as their performance has never been extensively analyzed. In this article, a rigorous analysis of fractional variants of the least mean squares and steepest descent algorithms is performed. Some critical schematic kinks in fractional learning algorithms are identified. Their origins and consequences on the performance of the learning algorithms are discussed and swift ready-witted remedies are proposed. Apposite numerical experiments are conducted to discuss the convergence and efficiency of the fractional learning algorithms in stochastic environments.

Abdul Wahab, Muhammad Anas Tahir, Naveed Iqbal et al.

Electricity load forecasting enables the grid operators to optimally implement the smart grid's most essential features such as demand response and energy efficiency. Electricity demand profiles can vary drastically from one region to another on diurnal, seasonal and yearly scale. Hence to devise a load forecasting technique that can yield the best estimates on diverse datasets, specially when the training data is limited, is a big challenge. This paper presents a deep learning architecture for short-term load forecasting based on bidirectional sequential models in conjunction with feature engineering that extracts the hand-crafted derived features in order to aid the model for better learning and predictions. In the proposed architecture, named as Deep Derived Feature Fusion (DeepDeFF), the raw input and hand-crafted features are trained at separate levels and then their respective outputs are combined to make the final prediction. The efficacy of the proposed methodology is evaluated on datasets from five countries with completely different patterns. The results demonstrate that the proposed technique is superior to the existing state of the art.

Abdul Wahab, Waqas Mehmood

Distributed ledger technology has gained wide popularity and adoption since the emergence of bitcoin in 2008 which is based on proof of work (PoW). It is a distributed, transparent and immutable database of records of all the transactions or events that have been shared and executed among the participants. All the transactions are verified and maintained by multiple nodes across a network without a central authority through a distributed cryptographic mechanism, a consensus protocol. It forms the core of this technology that not only validates the information appended to the ledger but also ensures the order in which it is appended across all the nodes. It is the foundation of its security, accountability and trust. While many researchers are working on improving the current protocol to be quantum resistant, fault-tolerant, and energy-efficient. Others are focused on developing different variants of the protocol, best suited for specific use cases. In this paper, we shall review different consensus protocols of distributed ledger technologies and their implementations. We shall also review their properties, concept and similar-work followed by a brief analysis.

Jaejun Yoo, Abdul Wahab, Jong Chul Ye

An inverse elastic source problem with sparse measurements is of concern. A generic mathematical framework is proposed which incorporates a low- dimensional manifold regularization in the conventional source reconstruction algorithms thereby enhancing their performance with sparse datasets. It is rigorously established that the proposed framework is equivalent to the so-called \emph{deep convolutional framelet expansion} in machine learning literature for inverse problems. Apposite numerical examples are furnished to substantiate the efficacy of the proposed framework.

Jaejun Yoo, Sohail Sabir, Duchang Heo et al.

Diffuse optical tomography (DOT) has been investigated as an alternative imaging modality for breast cancer detection thanks to its excellent contrast to hemoglobin oxidization level. However, due to the complicated non-linear photon scattering physics and ill-posedness, the conventional reconstruction algorithms are sensitive to imaging parameters such as boundary conditions. To address this, here we propose a novel deep learning approach that learns non-linear photon scattering physics and obtains an accurate three dimensional (3D) distribution of optical anomalies. In contrast to the traditional black-box deep learning approaches, our deep network is designed to invert the Lippman-Schwinger integral equation using the recent mathematical theory of deep convolutional framelets. As an example of clinical relevance, we applied the method to our prototype DOT system. We show that our deep neural network, trained with only simulation data, can accurately recover the location of anomalies within biomimetic phantoms and live animals without the use of an exogenous contrast agent.