Hanwen Bi

Hanwen Bi, Thushara D. Abhayapala

Machine learning and neural networks have advanced numerous research domains, but challenges such as large training data requirements and inconsistent model performance hinder their application in certain scientific problems. To overcome these challenges, researchers have investigated integrating physics principles into machine learning models, mainly through: (i) physics-guided loss functions, generally termed as physics-informed neural networks, and (ii) physics-guided architectural design. While both approaches have demonstrated success across multiple scientific disciplines, they have limitations including being trapped to a local minimum, poor interpretability, and restricted generalizability. This paper proposes a new physics-informed neural network (PINN) architecture that combines the strengths of both approaches by embedding the fundamental solution of the wave equation into the network architecture, enabling the learned model to strictly satisfy the wave equation. The proposed point neuron learning method can model an arbitrary sound field based on microphone observations without any dataset. Compared to other PINN methods, our approach directly processes complex numbers and offers better interpretability and generalizability. We evaluate the versatility of the proposed architecture by a sound field reconstruction problem in a reverberant environment. Results indicate that the point neuron method outperforms two competing methods and can efficiently handle noisy environments with sparse microphone observations.

Hanning Guo, Farah Abdellatif, Hanwen Bi et al.

Brain foundation models have achieved remarkable advances across a wide range of neuroscience tasks. However, most existing models are limited to a single functional modality, restricting their ability to exploit complementary spatiotemporal dynamics and the collective data scale across imaging techniques. To address this limitation, we propose Brain-OF, the first omnifunctional brain foundation model jointly pretrained on fMRI, EEG and MEG, capable of handling both unimodal and multimodal inputs within a unified framework. To reconcile heterogeneous spatiotemporal resolutions, we introduce the Any-Resolution Neural Signal Sampler, which projects diverse brain signals into a shared semantic space. To further manage semantic shifts, the Brain-OF backbone integrates DINT attention with a Sparse Mixture of Experts, where shared experts capture modality-invariant representations and routed experts specialize in modality-specific semantics. Furthermore, we propose Masked Temporal-Frequency Modeling, a dual-domain pretraining objective that jointly reconstructs brain signals in both the time and frequency domains. Brain-OF is pretrained on a large-scale corpus comprising around 40 datasets and demonstrates superior performance across diverse downstream tasks, highlighting the benefits of joint multimodal integration and dual-domain pretraining.

Xinzi He, Jia Guo, Xuzhe Zhang et al.

Unsupervised learning-based medical image registration approaches have witnessed rapid development in recent years. We propose to revisit a commonly ignored while simple and well-established principle: recursive refinement of deformation vector fields across scales. We introduce a recursive refinement network (RRN) for unsupervised medical image registration, to extract multi-scale features, construct normalized local cost correlation volume and recursively refine volumetric deformation vector fields. RRN achieves state of the art performance for 3D registration of expiratory-inspiratory pairs of CT lung scans. On DirLab COPDGene dataset, RRN returns an average Target Registration Error (TRE) of 0.83 mm, which corresponds to a 13% error reduction from the best result presented in the leaderboard. In addition to comparison with conventional methods, RRN leads to 89% error reduction compared to deep-learning-based peer approaches.