Daniel Gruhl

Joy T Wu, Daniel Beckmann, Sarah Miller et al.

[18F]FDG-PET/CT is a cornerstone imaging modality for tumor staging and treatment response assessment across many cancer types, yet expert reader shortages necessitate more efficient diagnostic aids. While standalone AI models for automatic lesion segmentation exist, clinical translation remains hindered by concerns about interpretability, explainability, reliability, and workflow integration. We present GazeXPErT, a 4D eye-tracking dataset capturing expert search patterns during tumor detection and measurement on 346 FDG-PET/CT scans. Each study was read by a trainee and a board-certified nuclear medicine or radiology specialist using an eye-tracking-enabled annotation platform that simulates routine clinical reads. From 3,948 minutes of raw 60Hz eye-tracking data, 9,030 unique gaze-to-lesion trajectories were extracted, synchronized with PET/CT image slices, and rendered in COCO-style format for multiple machine learning applications. Baseline validation experiments demonstrate that a 3D nnUNet tumor segmentation model achieved superior performance when incorporating expert gaze patterns versus without (DICE score 0.6819 versus 0.6008), and that vision transformers trained on sequential gaze and PET/CT images can improve dynamic lesion localization (74.95% predicted gaze point closer to tumor) and expert intention prediction (Accuracy 67.53% and AUROC 0.747). GazeXPErT is a valuable resource designed to explore multiple machine learning problems beyond these baseline experiments, which include and are not limited to, visual grounding or causal reasoning, clinically explainable feature augmentation, human-computer interaction, human intention prediction or understanding, and expert gaze-rewarded modeling approaches to AI in oncologic FDG-PET/CT imaging.

Muntasir Wahed, Daniel Gruhl, Alfredo Alba et al.

Recent advances in text representation have shown that training on large amounts of text is crucial for natural language understanding. However, models trained without predefined notions of topical interest typically require careful fine-tuning when transferred to specialized domains. When a sufficient amount of within-domain text may not be available, expanding a seed corpus of relevant documents from large-scale web data poses several challenges. First, corpus expansion requires scoring and ranking each document in the collection, an operation that can quickly become computationally expensive as the web corpora size grows. Relying on dense vector spaces and pairwise similarity adds to the computational expense. Secondly, as the domain concept becomes more nuanced, capturing the long tail of domain-specific rare terms becomes non-trivial, especially under limited seed corpora scenarios. In this paper, we consider the problem of fast approximate corpus expansion given a small seed corpus with a few relevant documents as a query, with the goal of capturing the long tail of a domain-specific set of concept terms. To efficiently collect large-scale domain-specific corpora with limited relevance feedback, we propose a novel truncated sparse document bit-vector representation, termed Signature Assisted Unsupervised Corpus Expansion (SAUCE). Experimental results show that SAUCE can reduce the computational burden while ensuring high within-domain lexical coverage.