Xiaomin Chen

Qi Chen, Yutong Xie, Biao Wu et al.

Automating radiology report generation can ease the reporting workload for radiologists. However, existing works focus mainly on the chest area due to the limited availability of public datasets for other regions. Besides, they often rely on naive data-driven approaches, e.g., a basic encoder-decoder framework with captioning loss, which limits their ability to recognise complex patterns across diverse anatomical regions. To address these issues, we propose X-RGen, a radiologist-minded report generation framework across six anatomical regions. In X-RGen, we seek to mimic the behaviour of human radiologists, breaking them down into four principal phases: 1) initial observation, 2) cross-region analysis, 3) medical interpretation, and 4) report formation. Firstly, we adopt an image encoder for feature extraction, akin to a radiologist's preliminary review. Secondly, we enhance the recognition capacity of the image encoder by analysing images and reports across various regions, mimicking how radiologists gain their experience and improve their professional ability from past cases. Thirdly, just as radiologists apply their expertise to interpret radiology images, we introduce radiological knowledge of multiple anatomical regions to further analyse the features from a clinical perspective. Lastly, we generate reports based on the medical-aware features using a typical auto-regressive text decoder. Both natural language generation (NLG) and clinical efficacy metrics show the effectiveness of X-RGen on six X-ray datasets. Our code and checkpoints are available at: https://github.com/YtongXie/X-RGen.

Zuo Fei, Kezhi Wang, Xiaomin Chen et al.

Computational psychiatry faces a fundamental trade-off: traditional reinforcement learning (RL) models offer interpretability but lack behavioral realism, while large language model (LLM) agents generate realistic behaviors but lack structural interpretability. We introduce BioLLMAgent, a novel hybrid framework that combines validated cognitive models with the generative capabilities of LLMs. The framework comprises three core components: (i) an Internal RL Engine for experience-driven value learning; (ii) an External LLM Shell for high-level cognitive strategies and therapeutic interventions; and (iii) a Decision Fusion Mechanism for integrating components via weighted utility. Comprehensive experiments on the Iowa Gambling Task (IGT) across six clinical and healthy datasets demonstrate that BioLLMAgent accurately reproduces human behavioral patterns while maintaining excellent parameter identifiability (correlations $>0.67$). Furthermore, the framework successfully simulates cognitive behavioral therapy (CBT) principles and reveals, through multi-agent dynamics, that community-wide educational interventions may outperform individual treatments. Validated across reward-punishment learning and temporal discounting tasks, BioLLMAgent provides a structurally interpretable "computational sandbox" for testing mechanistic hypotheses and intervention strategies in psychiatric research.

Jeyamohan Neera, Xiaomin Chen, Nauman Aslam et al.

Recommendation systems rely heavily on users behavioural and preferential data (e.g. ratings, likes) to produce accurate recommendations. However, users experience privacy concerns due to unethical data aggregation and analytical practices carried out by the Service Providers (SP). Local differential privacy (LDP) based perturbation mechanisms add noise to users data at user side before sending it to the SP. The SP then uses the perturbed data to perform recommendations. Although LDP protects the privacy of users from SP, it causes a substantial decline in predictive accuracy. To address this issue, we propose an LDP-based Matrix Factorization (MF) with a Gaussian Mixture Model (MoG). The LDP perturbation mechanism, Bounded Laplace (BLP), regulates the effect of noise by confining the perturbed ratings to a predetermined domain. We derive a sufficient condition of the scale parameter for BLP to satisfy $ε$ LDP. At the SP, The MoG model estimates the noise added to perturbed ratings and the MF algorithm predicts missing ratings. Our proposed LDP based recommendation system improves the recommendation accuracy without violating LDP principles. The empirical evaluations carried out on three real world datasets, i.e., Movielens, Libimseti and Jester, demonstrate that our method offers a substantial increase in predictive accuracy under strong privacy guarantee.