Xiaochun Zhang

Jirong Zha, Chenyu Zhao, Nan Zhou et al.

The growing relevance of multi-agent systems has drawn increasing focus on communication-efficient filters for collaborative perception to alleviate the system's communication burden. While the event-triggered (ET) mechanism can improve communication efficiency in collaborative state estimation, an inevitable trade-off exists between estimation accuracy and communication cost in ET filters. This paper proposes a fast and accurate ET diffusion-based filter for real-time multi-agent collaborative target tracking, aiming to reduce the system's data transmission without compromise in tracking performance. The proposed filter achieves improved tracking accuracy, reduced data transmission, and accelerated convergence using an error-minimized ET cubature information filter (CIF) for local estimation, and a correlation-aware diffusion strategy for global fusion. The experimental results confirm the scalability of the proposed EDC-CIF algorithm and demonstrate its efficacy in simultaneously reducing estimation error and computation time while significantly enhancing communication efficiency.

Jingke Chen, Jingrui Zhong, Tazneen Hossain Tani et al.

Despite the high accuracy of 'black box' deep learning models, drug discovery still relies on protein-ligand interaction principles and heuristics. To improve interpretability of protein-small molecule binding predictions, we developed the PWRules framework, which applies binding affinity data to identify privileged small molecule fragments and subsequently defines complementary pairing rules between these fragments and protein words (semantic sequence units) through an interpretability module. The resulting word-fragment rules are then ranked by the PWScore function to prioritize active compounds. Evaluations on benchmark datasets show that PWScore achieves competitive performance comparable to the physics-based model (Glide) and the deep learning model (PSICHIC) and shows broad applicability for protein targets outside the training dataset, e.g., SARS-CoV-2 main protease. Notably, PWScore captures complementary interaction information, yielding superior enrichment performance when integrated with these established methods. Structural analysis of protein-ligand complexes indicates that learned word-fragment rules are significantly enriched near ligand-binding pockets, despite training without explicit structural guidance. By extracting and applying complementary pairing rules, PWRules provides an interpretable framework for drug discovery.

Longkun Xu, Xiaochun Zhang, Qiantu Tuo et al.

Accurate time series forecasting underpins decision-making across domains, yet conventional ML development suffers from data scarcity in new deployments, poor adaptability under distribution shift, and diminishing returns from manual iteration. We propose Self-Evolving Agent for Time Series Algorithms (SEA-TS), a framework that autonomously generates, validates, and optimizes forecasting code via an iterative self-evolution loop. Our framework introduces three key innovations: (1) Metric-Advantage Monte Carlo Tree Search (MA-MCTS), which replaces fixed rewards with a normalized advantage score for discriminative search guidance; (2) Code Review with running prompt refinement, where each executed solution undergoes automated review followed by prompt updates that encode corrective patterns, preventing recurrence of similar errors; and (3) Global Steerable Reasoning, which compares each node against global best and worst solutions, enabling cross-trajectory knowledge transfer. We adopt a MAP-Elites archive for architectural diversity. On the public Solar-Energy benchmark, SEA-TS generated code achieves a 40% MAE reduction relative to TimeMixer, surpassing state-of-the-art methods. On proprietary datasets, SEA-TS generated code reduces WAPE by 8.6% on solar PV forecasting and 7.7% on residential load forecasting compared to human-engineered baselines, and achieves 26.17% MAPE on load forecasting versus 29.34% by TimeMixer. Notably, the evolved models discover novel architectural patterns--including physics-informed monotonic decay heads encoding solar irradiance constraints, per-station learned diurnal cycle profiles, and learnable hourly bias correction--demonstrating that autonomous ML engineering can generate genuinely novel algorithmic ideas beyond manual design.