George Webber

George Webber, Jack Sturgess, Ivan Martinovic

Behavioural biometric authentication systems entail an enrolment period that is burdensome for the user. In this work, we explore generating synthetic gestures from a few real user gestures with generative deep learning, with the application of training a simple (i.e. non-deep-learned) authentication model. Specifically, we show that utilising synthetic data alongside real data can reduce the number of real datapoints a user must provide to enrol into a biometric system. To validate our methods, we use the publicly available dataset of WatchAuth, a system proposed in 2022 for authenticating smartwatch payments using the physical gesture of reaching towards a payment terminal. We develop a regularised autoencoder model for generating synthetic user-specific wrist motion data representing these physical gestures, and demonstrate the diversity and fidelity of our synthetic gestures. We show that using synthetic gestures in training can improve classification ability for a real-world system. Through this technique we can reduce the number of gestures required to enrol a user into a WatchAuth-like system by more than 40% without negatively impacting its error rates.

George Webber, Yuya Mizuno, Oliver D. Howes et al.

Medical image reconstruction with pre-trained score-based generative models (SGMs) has advantages over other existing state-of-the-art deep-learned reconstruction methods, including improved resilience to different scanner setups and advanced image distribution modeling. SGM-based reconstruction has recently been applied to simulated positron emission tomography (PET) datasets, showing improved contrast recovery for out-of-distribution lesions relative to the state-of-the-art. However, existing methods for SGM-based reconstruction from PET data suffer from slow reconstruction, burdensome hyperparameter tuning and slice inconsistency effects (in 3D). In this work, we propose a practical methodology for fully 3D reconstruction that accelerates reconstruction and reduces the number of critical hyperparameters by matching the likelihood of an SGM's reverse diffusion process to a current iterate of the maximum-likelihood expectation maximization algorithm. Using the example of low-count reconstruction from simulated [$^{18}$F]DPA-714 datasets, we show our methodology can match or improve on the NRMSE and SSIM of existing state-of-the-art SGM-based PET reconstruction while reducing reconstruction time and the need for hyperparameter tuning. We evaluate our methodology against state-of-the-art supervised and conventional reconstruction algorithms. Finally, we demonstrate a first-ever implementation of SGM-based reconstruction for real 3D PET data, specifically [$^{18}$F]DPA-714 data, where we integrate perpendicular pre-trained SGMs to eliminate slice inconsistency issues.

George Webber

Making contactless payments using a smartwatch is increasingly popular, but this payment medium lacks traditional biometric security measures such as facial or fingerprint recognition. In 2022, Sturgess et al. proposed WatchAuth, a system for authenticating smartwatch payments using the physical gesture of reaching towards a payment terminal. While effective, the system requires the user to undergo a burdensome enrolment period to achieve acceptable error levels. In this dissertation, we explore whether applications of deep learning can reduce the number of gestures a user must provide to enrol into an authentication system for smartwatch payment. We firstly construct a deep-learned authentication system that outperforms the current state-of-the-art, including in a scenario where the target user has provided a limited number of gestures. We then develop a regularised autoencoder model for generating synthetic user-specific gestures. We show that using these gestures in training improves classification ability for an authentication system. Through this technique we can reduce the number of gestures required to enrol a user into a WatchAuth-like system without negatively impacting its error rates.

George Webber, Alexander Hammers, Andrew P. King et al.

Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a diffusion model (without sinogram data) on high-quality, but still noisy, PET images. In this work, we propose a simple method for generating subject-specific PET images from a dataset of multi-subject PET-MR scans, synthesizing "pseudo-PET" images by transforming between different patients' anatomy using image registration. The images we synthesize retain information from the subject's MR scan, leading to higher resolution and the retention of anatomical features compared to the original set of PET images. With simulated and real [$^{18}$F]FDG datasets, we show that pre-training a personalized diffusion model with subject-specific "pseudo-PET" images improves reconstruction accuracy with low-count data. In particular, the method shows promise in combining information from a guidance MR scan without overly imposing anatomical features, demonstrating an improved trade-off between reconstructing PET-unique image features versus features present in both PET and MR. We believe this approach for generating and utilizing synthetic data has further applications to medical imaging tasks, particularly because patient-specific PET images can be generated without resorting to generative deep learning or large training datasets.

George Webber, Alexander Hammers, Andrew P. King et al.

Diffusion models have recently enabled state-of-the-art reconstruction of positron emission tomography (PET) images while requiring only image training data. However, domain shift remains a key concern for clinical adoption: priors trained on images from one anatomy, acquisition protocol or pathology may produce artefacts on out-of-distribution data. We propose integrating steerable conditional diffusion (SCD) with our previously-introduced likelihood-scheduled diffusion (PET-LiSch) framework to improve the alignment of the diffusion model's prior to the target subject. At reconstruction time, for each diffusion step, we use low-rank adaptation (LoRA) to align the diffusion model prior with the target domain on the fly. Experiments on realistic synthetic 2D brain phantoms demonstrate that our approach suppresses hallucinated artefacts under domain shift, i.e. when our diffusion model is trained on perturbed images and tested on normal anatomy, our approach suppresses the hallucinated structure, outperforming both OSEM and diffusion model baselines qualitatively and quantitatively. These results provide a proof-of-concept that steerable priors can mitigate domain shift in diffusion-based PET reconstruction and motivate future evaluation on real data.

George Webber, Alexander Hammers, Andrew P King et al.

Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches have potential generalization advantages due to their independence from the scanner geometry and the injected activity level, they forgo the opportunity to explicitly model the interaction between the DM prior and noisy measurement data, potentially limiting reconstruction accuracy. To address this, we propose a supervised DM-based algorithm for PET reconstruction. Our method enforces the non-negativity of PET's Poisson likelihood model and accommodates the wide intensity range of PET images. Through experiments on realistic brain PET phantoms, we demonstrate that our approach outperforms or matches state-of-the-art deep learning-based methods quantitatively across a range of dose levels. We further conduct ablation studies to demonstrate the benefits of the proposed components in our model, as well as its dependence on training data, parameter count, and number of diffusion steps. Additionally, we show that our approach enables more accurate posterior sampling than unsupervised DM-based methods, suggesting improved uncertainty estimation. Finally, we extend our methodology to a practical approach for fully 3D PET and present example results from real [$^{18}$F]FDG brain PET data.