Boyang Fan

Boyang Fan, Hengchuang Yin, Siyu Yi et al.

Motivation: Multi-omics integration can improve cancer subtyping, but modality informativeness and noise vary across cancer types and patients. Existing graph-based methods optimize modality weights jointly with the classification objective and therefore lack independent reliability estimates, so low-quality omics distort patient similarity graphs and amplify noise through message passing. Results: We propose CMGL, a two-stage framework that estimates per-sample modality reliability through evidential deep learning and uses the frozen confidence scores to guide cross-omics fusion and graph construction. On four MLOmics cancer-subtype tasks and the 32-class pan-cancer task, CMGL consistently improves over the strongest baseline, surpassing it by 4.03% in average accuracy on the four single-cancer tasks. Its representations recover the PAM50 intrinsic subtypes of breast invasive carcinoma (BRCA), and the BRCA-trained model transfers without fine-tuning to kidney renal clear cell carcinoma (KIRC), stratifying patients into prognostically distinct groups.

Hao Yu, Xin Yang, Boyang Fan et al.

Continual learning (CL) for Foundation Models (FMs) is an essential yet underexplored challenge, especially in Federated Continual Learning (FCL), where each client learns from a private, evolving task stream under strict data and communication constraints. Despite their powerful generalization abilities, FMs often exhibit suboptimal performance on local downstream tasks, as they are unable to utilize private local data. Furthermore, enabling FMs to learn new tasks without forgetting prior knowledge is inherently a challenging problem, primarily due to their immense parameter count and high model complexity. In contrast, small models can be trained locally under resource-constrained conditions and benefit from more mature CL techniques. To bridge the gap between small models and FMs, we propose the first collaborative framework in FCL, where lightweight local models act as a dynamic bridge, continually adapting to new tasks while enhancing the utility of the large model. Two novel components are also included: Small Model Continual Fine-tuning is for preventing small models from temporal forgetting; One-by-One Distillation performs personalized fusion of heterogeneous local knowledge on the server. Experimental results demonstrate its superior performance, even when clients utilize heterogeneous small models.