Kai Xie

Shufa Wei, Xiaolong Xu, Xianbiao Qi et al.

Large Language Models (LLMs) have demonstrated exceptional capabilities across various natural language processing tasks. Yet, many of these advanced LLMs are tailored for broad, general-purpose applications. In this technical report, we introduce AcademicGPT, designed specifically to empower academic research. AcademicGPT is a continual training model derived from LLaMA2-70B. Our training corpus mainly consists of academic papers, thesis, content from some academic domain, high-quality Chinese data and others. While it may not be extensive in data scale, AcademicGPT marks our initial venture into a domain-specific GPT tailored for research area. We evaluate AcademicGPT on several established public benchmarks such as MMLU and CEval, as well as on some specialized academic benchmarks like PubMedQA, SCIEval, and our newly-created ComputerScienceQA, to demonstrate its ability from general knowledge ability, to Chinese ability, and to academic ability. Building upon AcademicGPT's foundation model, we also developed several applications catered to the academic area, including General Academic Question Answering, AI-assisted Paper Reading, Paper Review, and AI-assisted Title and Abstract Generation.

Yuqi Hu, Xiangyu Zhao, Gaowei Qing et al.

Background: MR-based subchondral bone effectively predicts knee osteoarthritis. However, its clinical application is limited by the cost and time of MR. Purpose: We aim to develop a novel distillation-learning-based method named SRRD for subchondral bone microstructural analysis using easily-acquired CT images, which leverages paired MR images to enhance the CT-based analysis model during training. Materials and Methods: Knee joint images of both CT and MR modalities were collected from October 2020 to May 2021. Firstly, we developed a GAN-based generative model to transform MR images into CT images, which was used to establish the anatomical correspondence between the two modalities. Next, we obtained numerous patches of subchondral bone regions of MR images, together with their trabecular parameters (BV / TV, Tb. Th, Tb. Sp, Tb. N) from the corresponding CT image patches via regression. The distillation-learning technique was used to train the regression model and transfer MR structural information to the CT-based model. The regressed trabecular parameters were further used for knee osteoarthritis classification. Results: A total of 80 participants were evaluated. CT-based regression results of trabecular parameters achieved intra-class correlation coefficients (ICCs) of 0.804, 0.773, 0.711, and 0.622 for BV / TV, Tb. Th, Tb. Sp, and Tb. N, respectively. The use of distillation learning significantly improved the performance of the CT-based knee osteoarthritis classification method using the CNN approach, yielding an AUC score of 0.767 (95% CI, 0.681-0.853) instead of 0.658 (95% CI, 0.574-0.742) (p<.001). Conclusions: The proposed SRRD method showed high reliability and validity in MR-CT registration, regression, and knee osteoarthritis classification, indicating the feasibility of subchondral bone microstructural analysis based on CT images.

He Cao, Siyu Liu, Fan Zhang et al.

Tool-augmented large language model (LLM) agents promise to unify scientific reasoning with computation, yet their deployment in high-stakes domains like drug discovery is bottlenecked by two critical barriers: unconstrained tool-use governance and poor long-horizon reliability. In dependency-heavy pharmaceutical pipelines, autonomous agents often drift into irreproducible trajectories, where early-stage hallucinations multiplicatively compound into downstream failures. To overcome this, we present Mozi, a dual-layer architecture that bridges the flexibility of generative AI with the deterministic rigor of computational biology. Layer A (Control Plane) establishes a governed supervisor--worker hierarchy that enforces role-based tool isolation, limits execution to constrained action spaces, and drives reflection-based replanning. Layer B (Workflow Plane) operationalizes canonical drug discovery stages -- from Target Identification to Lead Optimization -- as stateful, composable skill graphs. This layer integrates strict data contracts and strategic human-in-the-loop (HITL) checkpoints to safeguard scientific validity at high-uncertainty decision boundaries. Operating on the design principle of ``free-form reasoning for safe tasks, structured execution for long-horizon pipelines,'' Mozi provides built-in robustness mechanisms and trace-level audibility to completely mitigate error accumulation. We evaluate Mozi on PharmaBench, a curated benchmark for biomedical agents, demonstrating superior orchestration accuracy over existing baselines. Furthermore, through end-to-end therapeutic case studies, we demonstrate Mozi's ability to navigate massive chemical spaces, enforce stringent toxicity filters, and generate highly competitive in silico candidates, effectively transforming the LLM from a fragile conversationalist into a reliable, governed co-scientist.

Ying Wen, Kai Xie, Lianghua He

The encoder-decoder networks are commonly used in medical image segmentation due to their remarkable performance in hierarchical feature fusion. However, the expanding path for feature decoding and spatial recovery does not consider the long-term dependency when fusing feature maps from different layers, and the universal encoder-decoder network does not make full use of the multi-modality information to improve the network robustness especially for segmenting medical MRI. In this paper, we propose a novel feature fusion unit called Recurrent Decoding Cell (RDC) which leverages convolutional RNNs to memorize the long-term context information from the previous layers in the decoding phase. An encoder-decoder network, named Convolutional Recurrent Decoding Network (CRDN), is also proposed based on RDC for segmenting multi-modality medical MRI. CRDN adopts CNN backbone to encode image features and decode them hierarchically through a chain of RDCs to obtain the final high-resolution score map. The evaluation experiments on BrainWeb, MRBrainS and HVSMR datasets demonstrate that the introduction of RDC effectively improves the segmentation accuracy as well as reduces the model size, and the proposed CRDN owns its robustness to image noise and intensity non-uniformity in medical MRI.

Ze Wang, Zehao Xiao, Kai Xie et al.

Crowd counting usually addressed by density estimation becomes an increasingly important topic in computer vision due to its widespread applications in video surveillance, urban planning, and intelligence gathering. However, it is essentially a challenging task because of the greatly varied sizes of objects, coupled with severe occlusions and vague appearance of extremely small individuals. Existing methods heavily rely on multi-column learning architectures to extract multi-scale features, which however suffer from heavy computational cost, especially undesired for crowd counting. In this paper, we propose the single-column counting network (SCNet) for efficient crowd counting without relying on multi-column networks. SCNet consists of residual fusion modules (RFMs) for multi-scale feature extraction, a pyramid pooling module (PPM) for information fusion, and a sub-pixel convolutional module (SPCM) followed by a bilinear upsampling layer for resolution recovery. Those proposed modules enable our SCNet to fully capture multi-scale features in a compact single-column architecture and estimate high-resolution density map in an efficient way. In addition, we provide a principled paradigm for density map generation and data augmentation for training, which shows further improved performance. Extensive experiments on three benchmark datasets show that our SCNet delivers new state-of-the-art performance and surpasses previous methods by large margins, which demonstrates the great effectiveness of SCNet as a single-column network for crowd counting.