Zhisen Hu

Zhisen Hu, Dominic Cullen, Peter Thompson et al.

Radiographic knee alignment (KA) measurement is important for predicting joint health and surgical outcomes after total knee replacement. Traditional methods for KA measurements are manual, time-consuming and require long-leg radiographs. This study proposes a deep learning-based method to measure KA in anteroposterior knee radiographs via automatically localized knee anatomical landmarks. Our method builds on hourglass networks and incorporates an attention gate structure to enhance robustness and focus on key anatomical features. To our knowledge, this is the first deep learning-based method to localize over 100 knee anatomical landmarks to fully outline the knee shape while integrating KA measurements on both pre-operative and post-operative images. It provides highly accurate and reliable anatomical varus/valgus KA measurements using the anatomical tibiofemoral angle, achieving mean absolute differences ~1° when compared to clinical ground truth measurements. Agreement between automated and clinical measurements was excellent pre-operatively (intra-class correlation coefficient (ICC) = 0.97) and good post-operatively (ICC = 0.86). Our findings demonstrate that KA assessment can be automated with high accuracy, creating opportunities for digitally enhanced clinical workflows.

Zhisen Hu, Dominic Cullen, David S. Johnson et al.

Knee osteoarthritis (OA) is one of the most widespread and burdensome health problems [1-4]. Total knee replacement (TKR) may be offered as treatment for end-stage knee OA. Nevertheless, TKR is an invasive procedure involving prosthesis implantation at the knee joint, and around 10% of patients are dissatisfied following TKR [5,6]. Dissatisfaction is often assessed through patient-reported outcome measures (PROMs) [7], which are usually completed by patients and assessed by health professionals to evaluate the condition of TKR patients. In clinical practice, predicting poor TKR outcomes in advance could help optimise patient selection and improve management strategies. Radiographic knee alignment is an important biomarker for predicting TKR outcomes and long-term joint health. Abnormalities such as femoral or tibial deformities can directly influence surgical planning, implant selection, and postoperative recovery [8,9]. Traditional alignment measurement is manual, time-consuming, and requires long-leg radiographs, which are not always undertaken in clinical practice. Instead, standard anteroposterior (AP) knee radiographs are often the main imaging modality. Automated methods for alignment assessment in standard knee radiographs are potentially clinically valuable for improving efficiency in the knee OA treatment pathway.

Hao Dou, Chen Chen, Xiyuan Hu et al.

Generative Adversarial Networks (GAN) have been employed for face super resolution but they bring distorted facial details easily and still have weakness on recovering realistic texture. To further improve the performance of GAN based models on super-resolving face images, we propose PCA-SRGAN which pays attention to the cumulative discrimination in the orthogonal projection space spanned by PCA projection matrix of face data. By feeding the principal component projections ranging from structure to details into the discriminator, the discrimination difficulty will be greatly alleviated and the generator can be enhanced to reconstruct clearer contour and finer texture, helpful to achieve the high perception and low distortion eventually. This incremental orthogonal projection discrimination has ensured a precise optimization procedure from coarse to fine and avoids the dependence on the perceptual regularization. We conduct experiments on CelebA and FFHQ face datasets. The qualitative visual effect and quantitative evaluation have demonstrated the overwhelming performance of our model over related works.