Daniel C. G. Pedronette

Guilherme C. Oliveira, Gustavo H. Rosa, Daniel C. G. Pedronette et al. · microsoft-research

Deep learning applications for assessing medical images are limited because the datasets are often small and imbalanced. The use of synthetic data has been proposed in the literature, but neither a robust comparison of the different methods nor generalizability has been reported. Our approach integrates a retinal image quality assessment model and StyleGAN2 architecture to enhance Age-related Macular Degeneration (AMD) detection capabilities and improve generalizability. This work compares ten different Generative Adversarial Network (GAN) architectures to generate synthetic eye-fundus images with and without AMD. We combined subsets of three public databases (iChallenge-AMD, ODIR-2019, and RIADD) to form a single training and test set. We employed the STARE dataset for external validation, ensuring a comprehensive assessment of the proposed approach. The results show that StyleGAN2 reached the lowest Frechet Inception Distance (166.17), and clinicians could not accurately differentiate between real and synthetic images. ResNet-18 architecture obtained the best performance with 85% accuracy and outperformed the two human experts (80% and 75%) in detecting AMD fundus images. The accuracy rates were 82.8% for the test set and 81.3% for the STARE dataset, demonstrating the model's generalizability. The proposed methodology for synthetic medical image generation has been validated for robustness and accuracy, with free access to its code for further research and development in this field.

Luiz H. Buris, Daniel C. G. Pedronette, Joao P. Papa et al.

Deep learning architectures have achieved promising results in different areas (e.g., medicine, agriculture, and security). However, using those powerful techniques in many real applications becomes challenging due to the large labeled collections required during training. Several works have pursued solutions to overcome it by proposing strategies that can learn more for less, e.g., weakly and semi-supervised learning approaches. As these approaches do not usually address memorization and sensitivity to adversarial examples, this paper presents three deep metric learning approaches combined with Mixup for incomplete-supervision scenarios. We show that some state-of-the-art approaches in metric learning might not work well in such scenarios. Moreover, the proposed approaches outperform most of them in different datasets.