Caixia Dong

Duwei Dai, Caixia Dong, Guowei Dai et al.

Accurate skin lesion segmentation is vital for dermoscopic Computer-Aided Diagnosis. However, visual ambiguity and morphological irregularity often defeat spatial modeling, necessitating multi-domain architectures. Existing paradigms frequently overlook the active use of prediction uncertainty, leading to deterministic frameworks that suffer from blind cross-domain fusion and overfit to label noise. To address these issues, we propose the Uncertainty-Guided Dual-Domain Network (UGDD-Net). UGDD-Net introduces a novel "Glance-and-Gaze" mechanism to transform uncertainty into an active guiding signal. Specifically, the Uncertainty-Guided Bi-directional Feature Fusion (UGBFF) module uses pixel-level uncertainty to modulate spatial-spectral interactions. The Uncertainty-Guided Graph Refinement (UGGR) module constructs a topology-aware graph to propagate reliable semantic consensus and refine uncertain nodes. Finally, the Uncertainty-Guided Margin-Adaptive Loss (UGML) enforces strict constraints on confident pixels while relaxing penalties on uncertain ones to improve statistical calibration. Extensive experiments on ISIC2017, ISIC2018, PH2, and HAM10000 datasets demonstrate that UGDD-Net achieves state-of-the-art performance, especially on "Hard Samples". Our uncertainty maps align with expert inter-observer variability, providing robust interpretability for human-machine collaborative diagnosis.

Caixia Dong, Duwei Dai, Xinyi Han et al.

Accurate coronary artery segmentation is critical for computeraided diagnosis of coronary artery disease (CAD), yet it remains challenging due to the small size, complex morphology, and low contrast with surrounding tissues. To address these challenges, we propose a novel segmentation framework that leverages the power of vision foundation models (VFMs) through a parallel encoding architecture. Specifically, a vision transformer (ViT) encoder within the VFM captures global structural features, enhanced by the activation of the final two ViT blocks and the integration of an attention-guided enhancement (AGE) module, while a convolutional neural network (CNN) encoder extracts local details. These complementary features are adaptively fused using a cross-branch variational fusion (CVF) module, which models latent distributions and applies variational attention to assign modality-specific weights. Additionally, we introduce an evidential-learning uncertainty refinement (EUR) module, which quantifies uncertainty using evidence theory and refines uncertain regions by incorporating multi-scale feature aggregation and attention mechanisms, further enhancing segmentation accuracy. Extensive evaluations on one in-house and two public datasets demonstrate that the proposed framework significantly outperforms state-of-the-art methods, achieving superior performance in accurate coronary artery segmentation and showcasing strong generalization across multiple datasets. The code is available at https://github.com/d1c2x3/CAseg.