Rajendra Kumar

Lucian Chan, Rajendra Kumar, Marcel Verdonk et al.

Generative models for structure-based molecular design hold significant promise for drug discovery, with the potential to speed up the hit-to-lead development cycle, while improving the quality of drug candidates and reducing costs. Data sparsity and bias are, however, two main roadblocks to the development of 3D-aware models. Here we propose a first-in-kind training protocol based on multi-level contrastive learning for improved bias control and data efficiency. The framework leverages the large data resources available for 2D generative modelling with datasets of ligand-protein complexes. The result are hierarchical generative models that are topologically unbiased, explainable and customizable. We show how, by deconvolving the generative posterior into chemical, topological and structural context factors, we not only avoid common pitfalls in the design and evaluation of generative models, but furthermore gain detailed insight into the generative process itself. This improved transparency significantly aids method development, besides allowing fine-grained control over novelty vs familiarity.

Shashwat Agrawal, Amitabha Bagchi, Rajendra Kumar

This paper extends the Kikuchi method to give algorithms for decisional $k$-sparse Learning With Errors (LWE) and $k$-sparse Learning Parity with Noise (LPN) problems for higher moduli $q$. We create a Kikuchi graph for a sparse LWE/LPN instance and use it to give two attacks for these problems. The first attack decides by computing the spectral norm of the adjacency matrix of the Kikuchi graph, which is a generalization of the attack for $q=2$ given by Wein et. al. (Journal of the ACM 2019). The second approach computes non-trivial closed walks of the graph, and then decides by computing a certain polynomial of edge labels in the walks. This is a generalization of the attack for $q=2$ given by Gupta et. al. (SODA 2026). Both the attacks yield new tradeoffs between sample complexity and time complexity of sparse LWE/LPN.

Divesh Aggarwal, Yanlin Chen, Rajendra Kumar et al.

$ \newcommand{\SVP}{\textsf{SVP}} \newcommand{\CVP}{\textsf{CVP}} \newcommand{\eps}{\varepsilon} $We show a number of reductions between the Shortest Vector Problem and the Closest Vector Problem over lattices in different $\ell_p$ norms ($\SVP_p$ and $\CVP_p$ respectively). Specifically, we present the following $2^{\eps m}$-time reductions for $1 \leq p \leq q \leq \infty$, which all increase the rank $n$ and dimension $m$ of the input lattice by at most one: $\bullet$ a reduction from $\widetilde{O}(1/\eps^{1/p})γ$-approximate $\SVP_q$ to $γ$-approximate $\SVP_p$; $\bullet$ a reduction from $\widetilde{O}(1/\eps^{1/p}) γ$-approximate $\CVP_p$ to $γ$-approximate $\CVP_q$; and $\bullet$ a reduction from $\widetilde{O}(1/\eps^{1+1/p})$-$\CVP_q$ to $(1+\eps)$-unique $\SVP_p$ (which in turn trivially reduces to $(1+\eps)$-approximate $\SVP_p$). The last reduction is interesting even in the case $p = q$. In particular, this special case subsumes much prior work adapting $2^{O(m)}$-time $\SVP_p$ algorithms to solve $O(1)$-approximate $\CVP_p$. In the (important) special case when $p = q$, $1 \leq p \leq 2$, and the $\SVP_p$ oracle is exact, we show a stronger reduction, from $O(1/\eps^{1/p})\text{-}\CVP_p$ to (exact) $\SVP_p$ in $2^{\eps m}$ time. For example, taking $\eps = \log m/m$ and $p = 2$ gives a slight improvement over Kannan's celebrated polynomial-time reduction from $\sqrt{m}\text{-}\CVP_2$ to $\SVP_2$. We also note that the last two reductions can be combined to give a reduction from approximate-$\CVP_p$ to $\SVP_q$ for any $p$ and $q$, regardless of whether $p \leq q$ or $p > q$. Our techniques combine those from the recent breakthrough work of Eisenbrand and Venzin (which showed how to adapt the current fastest known algorithm for these problems in the $\ell_2$ norm to all $\ell_p$ norms) together with sparsification-based techniques.

Divesh Aggarwal, Yanlin Chen, Rajendra Kumar et al.

The most important computational problem on lattices is the Shortest Vector Problem (SVP). In this paper, we present new algorithms that improve the state-of-the-art for provable classical/quantum algorithms for SVP. We present the following results. $\bullet$ A new algorithm for SVP that provides a smooth tradeoff between time complexity and memory requirement. For any positive integer $4\leq q\leq \sqrt{n}$, our algorithm takes $q^{13n+o(n)}$ time and requires $poly(n)\cdot q^{16n/q^2}$ memory. This tradeoff which ranges from enumeration ($q=\sqrt{n}$) to sieving ($q$ constant), is a consequence of a new time-memory tradeoff for Discrete Gaussian sampling above the smoothing parameter. $\bullet$ A quantum algorithm for SVP that runs in time $2^{0.950n+o(n)}$ and requires $2^{0.5n+o(n)}$ classical memory and poly(n) qubits. In Quantum Random Access Memory (QRAM) model this algorithm takes only $2^{0.835n+o(n)}$ time and requires a QRAM of size $2^{0.293n+o(n)}$, poly(n) qubits and $2^{0.5n}$ classical space. This improves over the previously fastest classical (which is also the fastest quantum) algorithm due to [ADRS15] that has a time and space complexity $2^{n+o(n)}$. $\bullet$ A classical algorithm for SVP that runs in time $2^{1.669n+o(n)}$ time and $2^{0.5n+o(n)}$ space. This improves over an algorithm of [CCL18] that has the same space complexity. The time complexity of our classical and quantum algorithms are obtained using a known upper bound on a quantity related to the lattice kissing number which is $2^{0.402n}$. We conjecture that for most lattices this quantity is a $2^{o(n)}$. Assuming that this is the case, our classical algorithm runs in time $2^{1.292n+o(n)}$, our quantum algorithm runs in time $2^{0.750n+o(n)}$ and our quantum algorithm in QRAM model runs in time $2^{0.667n+o(n)}$.

Rajendra Kumar, Shashank K Mehta, Mahesh Sreekumar Rajasree

In this paper, we introduce the Maximum Distance Sublattice Problem (MDSP). We observed that the problem of solving an instance of the Closest Vector Problem (CVP) in a lattice $\mathcal{L}$ is the same as solving an instance of MDSP in the dual lattice of $\mathcal{L}$. We give an alternate reduction between the CVP and MDSP. This alternate reduction does not use the concept of dual lattice.

Vinod Kumar, S. K. Pandey, Rajendra Kumar

In the secure group communication, data is transmitted in such a way that only the group members are able to receive the messages. The main problem in the solution using symmetric key is heavy re-keying cost. To reduce re-keying cost tree based architecture is used. But it requires extra overhead to balance the key- tree in order to achieve logarithmic re-keying cost. The main challenging issue in dynamic and secure multimedia multicast communication is to design a centralized group key management scheme with minimal computational, communicational and storages complexities without breaching security issues. Several authors have proposed different centralized group key management schemes, wherein one of them proposes reducing communicational complexity but increases computational and storage costs however another proposes decreasing the computational and storage costs which eventually breaches forward and backward secrecy. In this paper we propose a comparatively more efficient centralized group key management scheme that not only minimize the computational, communicational and storages complexities but also maintaining the security at the optimal level. The message encryptions and decryptions costs are also minimized. Further, we also provide an extended multicast scheme, in which the several requests towards leaving or joining the group can be done by large number of members simultaneously. In order to obtain better performance of multicast encryption, the symmetric-key and asymmetric-key cryptosystems may be combined.