Anders Bjorholm Dahl

Patrick M. Jensen, Udaranga Wickramasinghe, Anders B. Dahl et al.

Shape priors have long been known to be effective when reconstructing 3D shapes from noisy or incomplete data. When using a deep-learning based shape representation, this often involves learning a latent representation, which can be either in the form of a single global vector or of multiple local ones. The latter allows more flexibility but is prone to overfitting. In this paper, we advocate a hybrid approach representing shapes in terms of 3D meshes with a separate latent vector at each vertex. During training the latent vectors are constrained to have the same value, which avoids overfitting. For inference, the latent vectors are updated independently while imposing spatial regularization constraints. We show that this gives us both flexibility and generalization capabilities, which we demonstrate on several medical image processing tasks.

August Leander Høeg, Sophia Wiinberg Bardenfleth, Hans Martin Kjer et al.

Recent advances in volumetric super-resolution (SR) have demonstrated strong performance in medical and scientific imaging, with transformer- and CNN-based approaches achieving impressive results even at extreme scaling factors. In this work, we show that much of this performance stems from training on downsampled data rather than real low-resolution scans. This reliance on downsampling is partly driven by the scarcity of paired high- and low-resolution 3D datasets. To address this, we introduce VoDaSuRe, a large-scale volumetric dataset containing paired high- and low-resolution scans. When training models on VoDaSuRe, we reveal a significant discrepancy: SR models trained on downsampled data produce substantially sharper predictions than those trained on real low-resolution scans, which smooth fine structures. Conversely, applying models trained on downsampled data to real scans preserves more structure but is inaccurate. Our findings suggest that current SR methods are overstated - when applied to real data, they do not recover structures lost in low-resolution scans and instead predict a smoothed average. We argue that progress in deep learning-based volumetric SR requires datasets with paired real scans of high complexity, such as VoDaSuRe. Our dataset and code are publicly available through: https://augusthoeg.github.io/VoDaSuRe/

Christian Møller Mikkelstrup, Anders Bjorholm Dahl, Philip Bille et al.

Computing a minimum $s$-$t$ cut in a graph is a solution to a wide range of computer vision problems, and is often done using the Boykov-Kolmogorov (BK) algorithm. In this paper, we revisit the BK algorithm from both a theoretical and practical point of view. We improve the analysis of the time complexity of the BK algorithm to $O(mn|C|)$ and propose a new algorithm, the fast and compact BK (fcBK) algorithm, with a time complexity of $O(m|C|)$, where $m$, $n$, and $|C|$ are the number of edges, number of vertices, and the capacity of the cut, respectively. We additionally propose a compact graph representation that allows our implementation to find a minimum $s$-$t$ cut in a graph with upwards of $10^9$ vertices and $10^{10}$ edges on a machine with 128 GB of memory. We find our implementation of the BK algorithm to be the fastest available implementation of the BK algorithm when evaluating on a comprehensive set of benchmark datasets, highlighting the importance of memory-efficient implementations. We make our implementations publicly available for further research and implementation development within minimum $s$-$t$ cut algorithms.

Jakob Lønborg Christensen, Vedrana Andersen Dahl, Morten Rieger Hannemose et al.

Uncertainty quantification (UQ) is crucial in safety-critical applications such as medical image segmentation. Total uncertainty is typically decomposed into data-related aleatoric uncertainty (AU) and model-related epistemic uncertainty (EU). Many methods exist for modeling AU (such as Probabilistic UNet, Diffusion) and EU (such as ensembles, MC Dropout), but it is unclear how they interact when combined. Additionally, recent work has revealed substantial entanglement between AU and EU, undermining the interpretability and practical usefulness of the decomposition. We present a comprehensive empirical study covering a broad range of AU-EU model combinations, propose a metric to quantify uncertainty entanglement, and evaluate both across downstream UQ tasks. For out-of-distribution detection, ensembles exhibit consistently lower entanglement and superior performance. For ambiguity modeling and calibration the best models are dataset-dependent, with softmax/SSN-based methods performing well and Probabilistic UNets being less entangled. A softmax ensemble fares remarkably well on all tasks. Finally, we analyze potential sources of uncertainty entanglement and outline directions for mitigating this effect.

Juan Miguel Valverde, Dim P. Papadopoulos, Rasmus Larsen et al.

Standard deep learning models for image segmentation cannot guarantee topology accuracy, failing to preserve the correct number of connected components or structures. This, in turn, affects the quality of the segmentations and compromises the reliability of the subsequent quantification analyses. Previous works have proposed to enhance topology accuracy with specialized frameworks, architectures, and loss functions. However, these methods are often cumbersome to integrate into existing training pipelines, they are computationally very expensive, or they are restricted to structures with tubular morphology. We present SCNP, an efficient method that improves topology accuracy by penalizing the logits with their poorest-classified neighbor, forcing the model to improve the prediction at the pixels' neighbors before allowing it to improve the pixels themselves. We show the effectiveness of SCNP across 13 datasets, covering different structure morphologies and image modalities, and integrate it into three frameworks for semantic and instance segmentation. Additionally, we show that SCNP can be integrated into several loss functions, making them improve topology accuracy. Our code can be found at https://jmlipman.github.io/SCNP-SameClassNeighborPenalization.

Pawel Tomasz Pieta, Anders Bjorholm Dahl, Jeppe Revall Frisvad et al.

The structure tensor method is often used for 2D and 3D analysis of imaged structures, but its results are in many cases very dependent on the user's choice of method parameters. We simplify this parameter choice in first order structure tensor scale-space by directly connecting the width of the derivative filter to the size of image features. By introducing a ring-filter step, we substitute the Gaussian integration/smoothing with a method that more accurately shifts the derivative filter response from feature edges to their center. We further demonstrate how extracted structural measures can be used to correct known inaccuracies in the scale map, resulting in a reliable representation of the feature sizes both in 2D and 3D. Compared to the traditional first order structure tensor, or previous structure tensor scale-space approaches, our solution is much more accurate and can serve as an out-of-the-box method for extracting a wide range of structural parameters with minimal user input.

Christian Keilstrup Ingwersen, Christian Mikkelstrup, Janus Nørtoft Jensen et al.

Accurate 3D human pose estimation is essential for sports analytics, coaching, and injury prevention. However, existing datasets for monocular pose estimation do not adequately capture the challenging and dynamic nature of sports movements. In response, we introduce SportsPose, a large-scale 3D human pose dataset consisting of highly dynamic sports movements. With more than 176,000 3D poses from 24 different subjects performing 5 different sports activities, SportsPose provides a diverse and comprehensive set of 3D poses that reflect the complex and dynamic nature of sports movements. Contrary to other markerless datasets we have quantitatively evaluated the precision of SportsPose by comparing our poses with a commercial marker-based system and achieve a mean error of 34.5 mm across all evaluation sequences. This is comparable to the error reported on the commonly used 3DPW dataset. We further introduce a new metric, local movement, which describes the movement of the wrist and ankle joints in relation to the body. With this, we show that SportsPose contains more movement than the Human3.6M and 3DPW datasets in these extremum joints, indicating that our movements are more dynamic. The dataset with accompanying code can be downloaded from our website. We hope that SportsPose will allow researchers and practitioners to develop and evaluate more effective models for the analysis of sports performance and injury prevention. With its realistic and diverse dataset, SportsPose provides a valuable resource for advancing the state-of-the-art in pose estimation in sports.

Patrick Møller Jensen, Vedrana Andersen Dahl, Carsten Gundlach et al.

Domain shift significantly influences the performance of deep learning algorithms, particularly for object detection within volumetric 3D images. Annotated training data is essential for deep learning-based object detection. However, annotating densely packed objects is time-consuming and costly. Instead, we suggest training models on individually scanned objects, causing a domain shift between training and detection data. To address this challenge, we introduce the BugNIST dataset, comprising 9154 micro-CT volumes of 12 bug types and 388 volumes of tightly packed bug mixtures. This dataset is characterized by having objects with the same appearance in the source and target domains, which is uncommon for other benchmark datasets for domain shift. During training, individual bug volumes labeled by class are utilized, while testing employs mixtures with center point annotations and bug type labels. Together with the dataset, we provide a baseline detection analysis, with the aim of advancing the field of 3D object detection methods.

Oskar Kristoffersen, Alba R. Sánchez, Morten R. Hannemose et al.

Geo-spatial analysis of our world benefits from a multimodal approach, as every single geographic location can be described in numerous ways (images from various viewpoints, textual descriptions, and geographic coordinates). Current geo-spatial benchmarks have limited coverage across modalities, considerably restricting progress in the field, as current approaches cannot integrate all relevant modalities within a unified framework. We introduce the Multi-Modal Landmark dataset (MMLANDMARKS), a benchmark composed of four modalities: 197k highresolution aerial images, 329k ground-view images, textual information, and geographic coordinates for 18,557 distinct landmarks in the United States. The MMLANDMARKS dataset has a one-to-one correspondence across every modality, which enables training and benchmarking models for various geo-spatial tasks, including cross-view Ground-to-Satellite retrieval, ground and satellite geolocalization, Text-to-Image, and Text-to-GPS retrieval. We demonstrate broad generalization and competitive performance against off-the-shelf foundational models and specialized state-of-the-art models across different tasks by employing a simple CLIP-inspired baseline, illustrating the necessity for multimodal datasets to achieve broad geo-spatial understanding.

Christian Keilstrup Ingwersen, Rasmus Tirsgaard, Rasmus Nylander et al.

Deducing a 3D human pose from a single 2D image is inherently challenging because multiple 3D poses can correspond to the same 2D representation. 3D data can resolve this pose ambiguity, but it is expensive to record and requires an intricate setup that is often restricted to controlled lab environments. We propose a method that improves the performance of deep learning-based monocular 3D human pose estimation models by using multiview data only during training, but not during inference. We introduce a novel loss function, consistency loss, which operates on two synchronized views. This approach is simpler than previous models that require 3D ground truth or intrinsic and extrinsic camera parameters. Our consistency loss penalizes differences in two pose sequences after rigid alignment. We also demonstrate that our consistency loss substantially improves performance for fine-tuning without requiring 3D data. Furthermore, we show that using our consistency loss can yield state-of-the-art performance when training models from scratch in a semi-supervised manner. Our findings provide a simple way to capture new data, e.g in a new domain. This data can be added using off-the-shelf cameras with no calibration requirements. We make all our code and data publicly available.

Juan Miguel Valverde, Motoya Koga, Nijihiko Otsuka et al.

We present TopoMortar, a brick wall dataset that is the first dataset specifically designed to evaluate topology-focused image segmentation methods, such as topology loss functions. Motivated by the known sensitivity of methods to dataset challenges, such as small training sets, noisy labels, and out-of-distribution test-set images, TopoMortar is created to enable in two ways investigating methods' effectiveness at improving topology accuracy. First, by eliminating dataset challenges that, as we show, impact the effectiveness of topology loss functions. Second, by allowing to represent different dataset challenges in the same dataset, isolating methods' performance from dataset challenges. TopoMortar includes three types of labels (accurate, pseudo-labels, and noisy labels), two fixed training sets (large and small), and in-distribution and out-of-distribution test-set images. We compared eight loss functions on TopoMortar, and we found that clDice achieved the most topologically accurate segmentations, and that the relative advantageousness of the other loss functions depends on the experimental setting. Additionally, we show that data augmentation and self-distillation can elevate Cross entropy Dice loss to surpass most topology loss functions, and that those simple methods can enhance topology loss functions as well. TopoMortar and our code can be found at https://jmlipman.github.io/TopoMortar

Juan Miguel Valverde, Maja Østergaard, Adrian Rodriguez-Palomo et al.

Accurate segmentation of thin, tubular structures (e.g., blood vessels) is challenging for deep neural networks. These networks classify individual pixels, and even minor misclassifications can break the thin connections within these structures. Existing methods for improving topology accuracy, such as topology loss functions, rely on very precise, topologically-accurate training labels, which are difficult to obtain. This is because annotating images, especially 3D images, is extremely laborious and time-consuming. Low image resolution and contrast further complicates the annotation by causing tubular structures to appear disconnected. We present CoLeTra, a data augmentation strategy that integrates to the models the prior knowledge that structures that appear broken are actually connected. This is achieved by creating images with the appearance of disconnected structures while maintaining the original labels. Our extensive experiments, involving different architectures, loss functions, and datasets, demonstrate that CoLeTra leads to segmentations topologically more accurate while often improving the Dice coefficient and Hausdorff distance. CoLeTra's hyper-parameters are intuitive to tune, and our sensitivity analysis shows that CoLeTra is robust to changes in these hyper-parameters. We also release a dataset specifically suited for image segmentation methods with a focus on topology accuracy. CoLetra's code can be found at https://github.com/jmlipman/CoLeTra.

August Leander Høeg, Sophia W. Bardenfleth, Hans Martin Kjer et al.

Until now, it has been difficult for volumetric super-resolution to utilize the recent advances in transformer-based models seen in 2D super-resolution. The memory required for self-attention in 3D volumes limits the receptive field. Therefore, long-range interactions are not used in 3D to the extent done in 2D and the strength of transformers is not realized. We propose a multi-scale transformer-based model based on hierarchical attention blocks combined with carrier tokens at multiple scales to overcome this. Here information from larger regions at coarse resolution is sequentially carried on to finer-resolution regions to predict the super-resolved image. Using transformer layers at each resolution, our coarse-to-fine modeling limits the number of tokens at each scale and enables attention over larger regions than what has previously been possible. We experimentally compare our method, MTVNet, against state-of-the-art volumetric super-resolution models on five 3D datasets demonstrating the advantage of an increased receptive field. This advantage is especially pronounced for images that are larger than what is seen in popularly used 3D datasets. Our code is available at https://github.com/AugustHoeg/MTVNet

Changlu Guo, Anders Nymark Christensen, Anders Bjorholm Dahl et al.

Visual counterfactual explanations aim to reveal the minimal semantic modifications that can alter a model's prediction, providing causal and interpretable insights into deep neural networks. However, existing diffusion-based counterfactual generation methods are often computationally expensive, slow to sample, and imprecise in localizing the modified regions. To address these limitations, we propose MaskDiME, a simple, fast, and effective diffusion framework that unifies semantic consistency and spatial precision through localized sampling. Our approach adaptively focuses on decision-relevant regions to achieve localized and semantically consistent counterfactual generation while preserving high image fidelity. Our training-free framework, MaskDiME, achieves over 30x faster inference than the baseline method and achieves comparable or state-of-the-art performance across five benchmark datasets spanning diverse visual domains, establishing a practical and generalizable solution for efficient counterfactual explanation.

Lezhong Wang, Shutong Jin, Ruiqi Cui et al.

Controlling illumination during video post-production is a crucial yet elusive goal in computational photography. Existing methods often lack flexibility, restricting users to certain relighting models. This paper introduces ReLumix, a novel framework that decouples the relighting algorithm from temporal synthesis, thereby enabling any image relighting technique to be seamlessly applied to video. Our approach reformulates video relighting into a simple yet effective two-stage process: (1) an artist relights a single reference frame using any preferred image-based technique (e.g., Diffusion Models, physics-based renderers); and (2) a fine-tuned stable video diffusion (SVD) model seamlessly propagates this target illumination throughout the sequence. To ensure temporal coherence and prevent artifacts, we introduce a gated cross-attention mechanism for smooth feature blending and a temporal bootstrapping strategy that harnesses SVD's powerful motion priors. Although trained on synthetic data, ReLumix shows competitive generalization to real-world videos. The method demonstrates significant improvements in visual fidelity, offering a scalable and versatile solution for dynamic lighting control.

Changlu Guo, Anders Nymark Christensen, Anders Bjorholm Dahl et al.

Retinal vessel segmentation is essential for early diagnosis of diseases such as diabetic retinopathy, hypertension, and neurodegenerative disorders. Although SA-UNet introduces spatial attention in the bottleneck, it underuses attention in skip connections and does not address the severe foreground-background imbalance. We propose SA-UNetv2, a lightweight model that injects cross-scale spatial attention into all skip connections to strengthen multi-scale feature fusion and adopts a weighted Binary Cross-Entropy (BCE) plus Matthews Correlation Coefficient (MCC) loss to improve robustness to class imbalance. On the public DRIVE and STARE datasets, SA-UNetv2 achieves state-of-the-art performance with only 1.2MB memory and 0.26M parameters (less than 50% of SA-UNet), and 1 second CPU inference on 592 x 592 x 3 images, demonstrating strong efficiency and deployability in resource-constrained, CPU-only settings.

Jakob Lønborg Christensen, Morten Rieger Hannemose, Anders Bjorholm Dahl et al.

Medical image segmentation often involves inherent uncertainty due to variations in expert annotations. Capturing this uncertainty is an important goal and previous works have used various generative image models for the purpose of representing the full distribution of plausible expert ground truths. In this work, we explore the design space of diffusion models for generative segmentation, investigating the impact of noise schedules, prediction types, and loss weightings. Notably, we find that making the noise schedule harder with input scaling significantly improves performance. We conclude that x- and v-prediction outperform epsilon-prediction, likely because the diffusion process is in the discrete segmentation domain. Many loss weightings achieve similar performance as long as they give enough weight to the end of the diffusion process. We base our experiments on the LIDC-IDRI lung lesion dataset and obtain state-of-the-art (SOTA) performance. Additionally, we introduce a randomly cropped variant of the LIDC-IDRI dataset that is better suited for uncertainty in image segmentation. Our model also achieves SOTA in this harder setting.

Pawel Tomasz Pieta, Peter Winkel Rasumssen, Anders Bjorholm Dahl et al.

Sphericity and roundness are fundamental measures used for assessing object uniformity in 2D and 3D images. However, using their strict definition makes computation costly. As both 2D and 3D microscopy imaging datasets grow larger, there is an increased demand for efficient algorithms that can quantify multiple objects in large volumes. We propose a novel approach for extracting sphericity and roundness based on the output of a local thickness algorithm. For sphericity, we simplify the surface area computation by modeling objects as spheroids/ellipses of varying lengths and widths of mean local thickness. For roundness, we avoid a complex corner curvature determination process by approximating it with local thickness values on the contour/surface of the object. The resulting methods provide an accurate representation of the exact measures while being significantly faster than their existing implementations.

William Michael Laprade, Jesper Cairo Westergaard, Svend Christensen et al.

Spectral imaging data acquired via multispectral and hyperspectral cameras can have hundreds of channels, where each channel records the reflectance at a specific wavelength and bandwidth. Time and resource constraints limit our ability to collect large spectral datasets, making it difficult to build and train predictive models from scratch. In the RGB domain, we can often alleviate some of the limitations of smaller datasets by using pretrained foundational models as a starting point. However, most existing foundation models are pretrained on large datasets of 3-channel RGB images, severely limiting their effectiveness when used with spectral imaging data. The few spectral foundation models that do exist usually have one of two limitations: (1) they are built and trained only on remote sensing data limiting their application in proximal spectral imaging, (2) they utilize the more widely available multispectral imaging datasets with less than 15 channels restricting their use with hundred-channel hyperspectral images. To alleviate these issues, we propose a large-scale foundational model and dataset built upon the masked autoencoder architecture that takes advantage of spectral channel encoding, spatial-spectral masking and ImageNet pretraining for an adaptable and robust model for downstream spectral imaging tasks.

Pawel Tomasz Pieta, Peter Winkel Rasmussen, Anders Bjorholm Dahl et al.

Influenced by the complexity of volumetric imaging, there is a shortage of established datasets useful for benchmarking volumetric deep-learning models. As a consequence, new and existing models are not easily comparable, limiting the development of architectures optimized specifically for volumetric data. To counteract this trend, we introduce MozzaVID - a large, clean, and versatile volumetric classification dataset. Our dataset contains X-ray computed tomography (CT) images of mozzarella microstructure and enables the classification of 25 cheese types and 149 cheese samples. We provide data in three different resolutions, resulting in three dataset instances containing from 591 to 37,824 images. While being general-purpose, the dataset also facilitates investigating mozzarella structure properties. The structure of food directly affects its functional properties and thus its consumption experience. Understanding food structure helps tune the production and mimicking it enables sustainable alternatives to animal-derived food products. The complex and disordered nature of food structures brings a unique challenge, where a choice of appropriate imaging method, scale, and sample size is not trivial. With this dataset we aim to address these complexities, contributing to more robust structural analysis models. The dataset can be downloaded from: https://archive.compute.dtu.dk/files/public/projects/MozzaVID/.

Patrick M. Jensen, Niels Jeppesen, Anders B. Dahl et al.

Minimum cut/maximum flow (min-cut/max-flow) algorithms solve a variety of problems in computer vision and thus significant effort has been put into developing fast min-cut/max-flow algorithms. As a result, it is difficult to choose an ideal algorithm for a given problem. Furthermore, parallel algorithms have not been thoroughly compared. In this paper, we evaluate the state-of-the-art serial and parallel min-cut/max-flow algorithms on the largest set of computer vision problems yet. We focus on generic algorithms, i.e., for unstructured graphs, but also compare with the specialized GridCut implementation. When applicable, GridCut performs best. Otherwise, the two pseudoflow algorithms, Hochbaum pseudoflow and excesses incremental breadth first search, achieves the overall best performance. The most memory efficient implementation tested is the Boykov-Kolmogorov algorithm. Amongst generic parallel algorithms, we find the bottom-up merging approach by Liu and Sun to be best, but no method is dominant. Of the generic parallel methods, only the parallel preflow push-relabel algorithm is able to efficiently scale with many processors across problem sizes, and no generic parallel method consistently outperforms serial algorithms. Finally, we provide and evaluate strategies for algorithm selection to obtain good expected performance. We make our dataset and implementations publicly available for further research.

Dolores Messer, Jakob Wilm, Eythor R. Eiriksson et al.

Full 3D scanning can efficiently be obtained using structured light scanning combined with a rotation stage. In this setting it is, however, necessary to reposition the object and scan it in different poses in order to cover the entire object. In this case, correspondence between the scans is lost, since the object was moved. In this paper, we propose a fully automatic method for aligning the scans of an object in two different poses. This is done by matching 2D features between images from two poses and utilizing correspondence between the images and the scanned point clouds. To demonstrate the approach, we present the results of scanning three dissimilar objects.

Wail Mustafa, Christian Kehl, Ulrik Lund Olsen et al.

Spectral computed tomography (CT) is an emerging technology capable of providing high chemical specificity, which is crucial for many applications such as detecting threats in luggage. This type of application requires both fast and high-quality image reconstruction and is often based on sparse-view (few) projections. The conventional filtered back projection (FBP) method is fast but it produces low-quality images dominated by noise and artifacts in sparse-view CT. Iterative methods with, e.g., total variation regularizers can circumvent that but they are computationally expensive, as the computational load proportionally increases with the number of spectral channels. Instead, we propose an approach for fast reconstruction of sparse-view spectral CT data using a U-Net convolutional neural network architecture with multi-channel input and output. The network is trained to output high-quality CT images from FBP input image reconstructions. Our method is fast at run-time and because the internal convolutions are shared between the channels, the computational load increases only at the first and last layers, making it an efficient approach to process spectral data with a large number of channels. We have validated our approach using real CT scans. Our results show qualitatively and quantitatively that our approach outperforms the state-of-the-art iterative methods. Furthermore, the results indicate that the network can exploit the coupling of the channels to enhance the overall quality and robustness.

Jakeoung Koo, Anders B. Dahl, J. Andreas Bærentzen et al.

In computed tomography, the reconstruction is typically obtained on a voxel grid. In this work, however, we propose a mesh-based reconstruction method. For tomographic problems, 3D meshes have mostly been studied to simulate data acquisition, but not for reconstruction, for which a 3D mesh means the inverse process of estimating shapes from projections. In this paper, we propose a differentiable forward model for 3D meshes that bridge the gap between the forward model for 3D surfaces and optimization. We view the forward projection as a rendering process, and make it differentiable by extending recent work in differentiable rendering. We use the proposed forward model to reconstruct 3D shapes directly from projections. Experimental results for single-object problems show that the proposed method outperforms traditional voxel-based methods on noisy simulated data. We also apply the proposed method on electron tomography images of nanoparticles to demonstrate the applicability of the method on real data.

Christian Kehl, Wail Mustafa, Jan Kehres et al.

Multi-spectral computed tomography is an emerging technology for the non-destructive identification of object materials and the study of their physical properties. Applications of this technology can be found in various scientific and industrial contexts, such as luggage scanning at airports. Material distinction and its identification is challenging, even with spectral x-ray information, due to acquisition noise, tomographic reconstruction artefacts and scanning setup application constraints. We present MUSIC - and open access multi-spectral CT dataset in 2D and 3D - to promote further research in the area of material identification. We demonstrate the value of this dataset on the image analysis challenge of object segmentation purely based on the spectral response of its composing materials. In this context, we compare the segmentation accuracy of fast adaptive mean shift (FAMS) and unconstrained graph cuts on both datasets. We further discuss the impact of reconstruction artefacts and segmentation controls on the achievable results. Dataset, related software packages and further documentation are made available to the imaging community in an open-access manner to promote further data-driven research on the subject

Vedrana Andersen Dahl, Monica Jane Emerson, Camilla Himmelstrup Trinderup et al.

Efficient and easy segmentation of images and volumes is of great practical importance. Segmentation problems that motivate our approach originate from microscopy imaging commonly used in materials science, medicine, and biology. We formulate image segmentation as a probabilistic pixel classification problem, and we apply segmentation as a step towards characterising image content. Our method allows the user to define structures of interest by interactively marking a subset of pixels. Thanks to the real-time feedback, the user can place new markings strategically, depending on the current outcome. The final pixel classification may be obtained from a very modest user input. An important ingredient of our method is a graph that encodes image content. This graph is built in an unsupervised manner during initialisation and is based on clustering of image features. Since we combine a limited amount of user-labelled data with the clustering information obtained from the unlabelled parts of the image, our method fits in the general framework of semi-supervised learning. We demonstrate how this can be a very efficient approach to segmentation through pixel classification.

Mitko Veta, Paul J. van Diest, Stefan M. Willems et al.

The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis counting is laborious, subjective and may suffer from low inter-observer agreement. With the wider acceptance of whole slide images in pathology labs, automatic image analysis has been proposed as a potential solution for these issues. In this paper, the results from the Assessment of Mitosis Detection Algorithms 2013 (AMIDA13) challenge are described. The challenge was based on a data set consisting of 12 training and 11 testing subjects, with more than one thousand annotated mitotic figures by multiple observers. Short descriptions and results from the evaluation of eleven methods are presented. The top performing method has an error rate that is comparable to the inter-observer agreement among pathologists.