Alexey Ovchinnikov

Alexey Ovchinnikov, Pedro Soto

Global parameter identifiability is a property of a parametric ODE model to recover the parameter values uniquely from the input-output data. Not all parametric ODE models have this property, and checking for parameter identifiability is a prerequisite to perform numerical parameter estimation. There are many algorithms and software packages for global parameter identifiability, and frequently the runtime is large. However, the computational complexity for this problem has not been analyzed yet, though there are complexity results for local (finitely many values fit the data) parameter identifiability. In this paper, we estimate the complexity of checking global parameter identifiability over real fields for ODE models that depend linearly on the state variables and rationally on the parameters. In particular, we prove that it is equivalent to the injectivity problem.

Hoon Hong, Alexey Ovchinnikov, Gleb Pogudin et al.

Biological processes are often modeled by ordinary differential equations with unknown parameters. The unknown parameters are usually estimated from experimental data. In some cases, due to the structure of the model, this estimation problem does not have a unique solution even in the case of continuous noise-free data. It is therefore desirable to check the uniqueness a priori before carrying out actual experiments. We present a new software SIAN (Structural Identifiability ANalyser) that does this. Our software can tackle problems that could not be tackled by previously developed packages.

Ilia Ilmer, Alexey Ovchinnikov, Gleb Pogudin et al.

Structural global parameter identifiability indicates whether one can determine a parameter's value from given inputs and outputs in the absence of noise. If a given model has parameters for which there may be infinitely many values, such parameters are called non-identifiable. We present a procedure for accelerating a global identifiability query by eliminating algebraically independent non-identifiable parameters. Our proposed approach significantly improves performance across different computer algebra frameworks.