Zhe Sage Chen

Zhe Sage Chen, Prathamesh, Kulkarni et al.

In light of the NIMH's Research Domain Criteria (RDoC), the advent of functional neuroimaging, novel technologies and methods provide new opportunities to develop precise and personalized prognosis and diagnosis of mental disorders. Machine learning (ML) and artificial intelligence (AI) technologies are playing an increasingly critical role in the new era of precision psychiatry. Combining ML/AI with neuromodulation technologies can potentially provide explainable solutions in clinical practice and effective therapeutic treatment. Advanced wearable and mobile technologies also call for the new role of ML/AI for digital phenotyping in mobile mental health. In this review, we provide a comprehensive review of the ML methodologies and applications by combining neuroimaging, neuromodulation, and advanced mobile technologies in psychiatry practice. Additionally, we review the role of ML in molecular phenotyping and cross-species biomarker identification in precision psychiatry. We further discuss explainable AI (XAI) and causality testing in a closed-human-in-the-loop manner, and highlight the ML potential in multimedia information extraction and multimodal data fusion. Finally, we discuss conceptual and practical challenges in precision psychiatry and highlight ML opportunities in future research.

Ran Wang, Zhe Sage Chen

Recent advances in machine learning have made revolutionary breakthroughs in computer games, image and natural language understanding, and scientific discovery. Foundation models and large-scale language models (LLMs) have recently achieved human-like intelligence thanks to BigData. With the help of self-supervised learning (SSL) and transfer learning, these models may potentially reshape the landscapes of neuroscience research and make a significant impact on the future. Here we present a mini-review on recent advances in foundation models and generative AI models as well as their applications in neuroscience, including natural language and speech, semantic memory, brain-machine interfaces (BMIs), and data augmentation. We argue that this paradigm-shift framework will open new avenues for many neuroscience research directions and discuss the accompanying challenges and opportunities.

Zhe Sage Chen, Quanyan Zhu

We propose a game-theoretic framework for adaptive multi-agent intelligent systems. Unlike classical game theory, which often treats strategies as primitive objects chosen by perfectly rational agents, the proposed framework provides a mathematical foundation for studying equilibrium in NeuroAI and can be viewed as an extension of game theory under relaxed assumptions, including partial observability, bounded computation, and uncertainty. At its core, Multilevel Interactive Equilibrium (MIE) generalizes the classical Nash equilibrium to intelligent systems with internal computation. Rather than being defined solely at the level of observable behavior, equilibrium emerges when neural learning dynamics, cognitive representations, and behavioral strategies mutually stabilize between interacting agents. This framework applies uniformly to interactions between two biological brains, two artificial agents, or hybrid human-AI systems. We discuss applications of multilevel game theory to human-autonomous vehicle driving, human-machine interaction, human-large language model (LLM) interaction, and computational psychiatry. We also outline experimental strategies and computational methods for estimating MIE and discuss challenges and prospects for future research.