Jalal Al-afandi

Jalal Al-afandi, Bálint Magyar, András Horváth

Data augmentation is a commonly applied technique with two seemingly related advantages. With this method one can increase the size of the training set generating new samples and also increase the invariance of the network against the applied transformations. Unfortunately all images contain both relevant and irrelevant features for classification therefore this invariance has to be class specific. In this paper we will present a new method which uses saliency maps to restrict the invariance of neural networks to certain regions, providing higher test accuracy in classification tasks.

Attila Pintér, Javier Rico, Attila Répai et al.

We present KAYRA, an end-to-end karyotyping system that operates inside the operational constraints of a clinical cytogenetic laboratory. KAYRA is architected as a containerized microservice pipeline whose ML stack combines an EfficientNet-B5 + U-Net semantic segmenter, a Mask R-CNN (ResNet-50 + FPN) instance detector, and a ResNet-18 classifier, orchestrated through a cascaded ROI-narrowing strategy that focuses each downstream model on the chromosome-bearing region. The same container images are deployed both as a cloud service and as an on-premise installation, supporting clinical environments where patient-data egress is not permitted as well as those where it is. A pilot clinical evaluation against two commercial reference karyotyping systems on 459 chromosomes from 10 metaphase spreads shows segmentation accuracy of 98.91 % (vs. 78.21 % / 40.52 %), classification accuracy of 89.1 % (vs. 86.9 % / 54.5 %), and rotation accuracy of 89.76 % (vs. 94.55 % / 78.43 %). KAYRA improves over the older density-thresholding reference on all three axes (p < 0.0001 for segmentation and classification by Fisher's exact test on chromosome-level counts), and on segmentation also against the modern AI- supported reference (p < 0.0001); on classification the difference vs. the modern AI reference is not statistically significant at the present test-set size (p = 0.34). The system reaches TRL 6 maturity and integrates the human-in-the-loop expert-review workflow that diagnostic cytogenetic practice requires. The thesis of this paper is that a multi-model cytogenetic AI service can be packaged as a microservice architecture supporting flexible deployment - cloud-hosted or on-premise - while delivering strong empirical performance on a pilot clinical evaluation.

Andras Horvath, Jalal Al-afandi

It is a common assumption that the activation of different layers in neural networks follow Gaussian distribution. This distribution can be transformed using normalization techniques, such as batch-normalization, increasing convergence speed and improving accuracy. In this paper we would like to demonstrate, that activations do not necessarily follow Gaussian distribution in all layers. Neurons in deeper layers are more selective and specific which can result extremely large, out-of-distribution activations. We will demonstrate that one can create more consistent mean and variance values for batch normalization during training by filtering out these activations which can further improve convergence speed and yield higher validation accuracy.

Kálmán Szentannai, Jalal Al-Afandi, András Horváth

Deep Neural Networks are robust to minor perturbations of the learned network parameters and their minor modifications do not change the overall network response significantly. This allows space for model stealing, where a malevolent attacker can steal an already trained network, modify the weights and claim the new network his own intellectual property. In certain cases this can prevent the free distribution and application of networks in the embedded domain. In this paper, we propose a method for creating an equivalent version of an already trained fully connected deep neural network that can prevent network stealing: namely, it produces the same responses and classification accuracy, but it is extremely sensitive to weight changes.