Bowen Tong, Hao Chen, Shaorui Guo et al.
Microwave Tomography (MWT) aims to reconstruct the dielectric properties of tissues from measured scattered electromagnetic fields. This inverse problem is highly nonlinear and ill-posed, posing significant challenges for conventional optimization-based methods, which, despite being grounded in physical models, often fail to recover fine structural details. Recent deep learning strategies, including end-to-end and post-processing networks, have improved reconstruction quality but typically require large paired training datasets and may struggle to generalize. To overcome these limitations, we propose a physics-informed hybrid framework that integrates diffusion models as learned regularization within a data-consistency-driven variational scheme. Specifically, we introduce Single-Step Diffusion Regularization (SSD-Reg), a novel approach that embeds diffusion priors into the iterative reconstruction process, enabling the recovery of complex anatomical structures without the need for paired data. SSD-Reg maintains fidelity to both the governing physics and learned structural distributions, improving accuracy, stability, and robustness. Extensive experiments demonstrate that SSD-Reg, implemented as a Plug-and-Play (PnP) module, provides a flexible and effective solution for tackling the ill-posedness inherent in functional image reconstruction.