Jian Gao

Shuang Li, Yibing Wang, Jian Gao et al.

Large-scale 3D photoacoustic (PA) imaging has become increasingly important for both clinical and pre-clinical applications. Limited by cost and system complexity, only systems with sparsely-distributed sensors can be widely implemented, which desires advanced reconstruction algorithms to reduce artifacts. However, high computing memory and time consumption of traditional iterative reconstruction (IR) algorithms is practically unacceptable for large-scale 3D PA imaging. Here, we propose a point cloud-based IR algorithm that reduces memory consumption by several orders, wherein the 3D PA scene is modeled as a series of Gaussian-distributed spherical sources stored in form of point cloud. During the IR process, not only are properties of each Gaussian source, including its peak intensity (initial pressure value), standard deviation (size) and mean (position) continuously optimized, but also each Gaussian source itself adaptively undergoes destroying, splitting, and duplication along the gradient direction. This method, named the sliding Gaussian ball adaptive growth (SlingBAG) algorithm, enables high-quality large-scale 3D PA reconstruction with fast iteration and extremely low memory usage. We validated SlingBAG algorithm in both simulation study and in vivo animal experiments. The source code and data for SlingBAG, along with supplementary materials and demonstration videos, are now available in the following GitHub repository: https://github.com/JaegerCQ/SlingBAG.

Shuang Li, Yibing Wang, Jian Gao et al.

Large-scale dynamic three-dimensional (3D) photoacoustic imaging (PAI) is significantly important in clinical applications. In practical implementations, large-scale 3D real-time PAI systems typically utilize sparse two-dimensional (2D) sensor arrays with certain angular deficiencies, necessitating advanced iterative reconstruction (IR) algorithms to achieve quantitative PAI and reduce reconstruction artifacts. However, for existing IR algorithms, multi-frame 3D reconstruction leads to extremely high memory consumption and prolonged computation time, with limited consideration of the spatial-temporal continuity between data frames. Here, we propose a novel method, named the 4D sliding Gaussian ball adaptive growth (4D SlingBAG) algorithm, based on the current point cloud-based IR algorithm sliding Gaussian ball adaptive growth (SlingBAG), which has minimal memory consumption among IR methods. Our 4D SlingBAG method applies spatial-temporal coupled deformation functions to each Gaussian sphere in point cloud, thus explicitly learning the deformations features of the dynamic 3D PA scene. This allows for the efficient representation of various physiological processes (such as pulsation) or external pressures (e.g., blood perfusion experiments) contributing to changes in vessel morphology and blood flow during dynamic 3D PAI, enabling highly efficient IR for dynamic 3D PAI. Simulation experiments demonstrate that 4D SlingBAG achieves high-quality dynamic 3D PA reconstruction. Compared to performing reconstructions by using SlingBAG algorithm individually for each frame, our method significantly reduces computational time and keeps a extremely low memory consumption. The project for 4D SlingBAG can be found in the following GitHub repository: \href{https://github.com/JaegerCQ/4D-SlingBAG}{https://github.com/JaegerCQ/4D-SlingBAG}.

Jian Gao, Fufangchen Zhao, Yiyang Zhang et al.

Poor sitting posture is a critical yet often overlooked factor contributing to long-term musculoskeletal disorders and physiological dysfunctions. Existing sitting posture monitoring systems, although leveraging visual, IMU, or pressure-based modalities, often suffer from coarse-grained recognition and lack the semantic expressiveness necessary for personalized feedback. In this paper, we propose \textbf{SitLLM}, a lightweight multimodal framework that integrates flexible pressure sensing with large language models (LLMs) to enable fine-grained posture understanding and personalized health-oriented response generation. SitLLM comprises three key components: (1) a \textit{Gaussian-Robust Sensor Embedding Module} that partitions pressure maps into spatial patches and injects local noise perturbations for robust feature extraction; (2) a \textit{Prompt-Driven Cross-Modal Alignment Module} that reprograms sensor embeddings into the LLM's semantic space via multi-head cross-attention using the pre-trained vocabulary embeddings; and (3) a \textit{Multi-Context Prompt Module} that fuses feature-level, structure-level, statistical-level, and semantic-level contextual information to guide instruction comprehension.