Angel Jimenez-Fernandez

Daniel Casanueva-Morato, Alvaro Ayuso-Martinez, Juan P. Dominguez-Morales et al.

The nervous system, more specifically, the brain, is capable of solving complex problems simply and efficiently, far surpassing modern computers. In this regard, neuromorphic engineering is a research field that focuses on mimicking the basic principles that govern the brain in order to develop systems that achieve such computational capabilities. Within this field, bio-inspired learning and memory systems are still a challenge to be solved, and this is where the hippocampus is involved. It is the region of the brain that acts as a short-term memory, allowing the learning and unstructured and rapid storage of information from all the sensory nuclei of the cerebral cortex and its subsequent recall. In this work, we propose a novel bio-inspired memory model based on the hippocampus with the ability to learn memories, recall them from a cue (a part of the memory associated with the rest of the content) and even forget memories when trying to learn others with the same cue. This model has been implemented on the SpiNNaker hardware platform using Spiking Neural Networks, and a set of experiments and tests were performed to demonstrate its correct and expected operation. The proposed spike-based memory model generates spikes only when it receives an input, being energy efficient, and it needs 7 timesteps for the learning step and 6 timesteps for recalling a previously-stored memory. This work presents the first hardware implementation of a fully functional bio-inspired spike-based hippocampus memory model, paving the road for the development of future more complex neuromorphic systems.

Daniel Casanueva-Morato, Alvaro Ayuso-Martinez, Juan P. Dominguez-Morales et al.

The human brain is the most powerful and efficient machine in existence today, surpassing in many ways the capabilities of modern computers. Currently, lines of research in neuromorphic engineering are trying to develop hardware that mimics the functioning of the brain to acquire these superior capabilities. One of the areas still under development is the design of bio-inspired memories, where the hippocampus plays an important role. This region of the brain acts as a short-term memory with the ability to store associations of information from different sensory streams in the brain and recall them later. This is possible thanks to the recurrent collateral network architecture that constitutes CA3, the main sub-region of the hippocampus. In this work, we developed two spike-based computational models of fully functional hippocampal bio-inspired memories for the storage and recall of complex patterns implemented with spiking neural networks on the SpiNNaker hardware platform. These models present different levels of biological abstraction, with the first model having a constant oscillatory activity closer to the biological model, and the second one having an energy-efficient regulated activity, which, although it is still bio-inspired, opts for a more functional approach. Different experiments were performed for each of the models, in order to test their learning/recalling capabilities. A comprehensive comparison between the functionality and the biological plausibility of the presented models was carried out, showing their strengths and weaknesses. The two models, which are publicly available for researchers, could pave the way for future spike-based implementations and applications.

Daniel Casanueva-Morato, Alvaro Ayuso-Martinez, Juan P. Dominguez-Morales et al.

The brain has computational capabilities that surpass those of modern systems, being able to solve complex problems efficiently in a simple way. Neuromorphic engineering aims to mimic biology in order to develop new systems capable of incorporating such capabilities. Bio-inspired learning systems continue to be a challenge that must be solved, and much work needs to be done in this regard. Among all brain regions, the hippocampus stands out as an autoassociative short-term memory with the capacity to learn and recall memories from any fragment of them. These characteristics make the hippocampus an ideal candidate for developing bio-inspired learning systems that, in addition, resemble content-addressable memories. Therefore, in this work we propose a bio-inspired spiking content-addressable memory model based on the CA3 region of the hippocampus with the ability to learn, forget and recall memories, both orthogonal and non-orthogonal, from any fragment of them. The model was implemented on the SpiNNaker hardware platform using Spiking Neural Networks. A set of experiments based on functional, stress and applicability tests were performed to demonstrate its correct functioning. This work presents the first hardware implementation of a fully-functional bio-inspired spiking hippocampal content-addressable memory model, paving the way for the development of future more complex neuromorphic systems.

Daniel Casanueva-Morato, Alvaro Ayuso-Martinez, Juan P. Dominguez-Morales et al.

The brain has a great capacity for computation and efficient resolution of complex problems, far surpassing modern computers. Neuromorphic engineering seeks to mimic the basic principles of the brain to develop systems capable of achieving such capabilities. In the neuromorphic field, navigation systems are of great interest due to their potential applicability to robotics, although these systems are still a challenge to be solved. This work proposes a spike-based robotic navigation and environment pseudomapping system formed by a bio-inspired hippocampal memory model connected to a Posterior Parietal Cortex model. The hippocampus is in charge of maintaining a representation of an environment state map, and the PPC is in charge of local decision-making. This system was implemented on the SpiNNaker hardware platform using Spiking Neural Networks. A set of real-time experiments was applied to demonstrate the correct functioning of the system in virtual and physical environments on a robotic platform. The system is able to navigate through the environment to reach a goal position starting from an initial position, avoiding obstacles and mapping the environment. To the best of the authors knowledge, this is the first implementation of an environment pseudo-mapping system with dynamic learning based on a bio-inspired hippocampal memory.

Marco Rasetto, Juan P. Dominguez-Morales, Angel Jimenez-Fernandez et al.

In recent years tremendous efforts have been done to advance the state of the art for Natural Language Processing (NLP) and audio recognition. However, these efforts often translated in increased power consumption and memory requirements for bigger and more complex models. These solutions falls short of the constraints of IoT devices which need low power, low memory efficient computation, and therefore they fail to meet the growing demand of efficient edge computing. Neuromorphic systems have proved to be excellent candidates for low-power low-latency computation in a multitude of applications. For this reason we present a neuromorphic architecture, capable of unsupervised auditory feature recognition. We then validate the network on a subset of Google's Speech Commands dataset.

Lourdes Duran-Lopez, Juan P. Dominguez-Morales, Daniel Gutierrez-Galan et al.

Prostate cancer (PCa) is one of the most commonly diagnosed cancer and one of the leading causes of death among men, with almost 1.41 million new cases and around 375,000 deaths in 2020. Artificial Intelligence algorithms have had a huge impact in medical image analysis, including digital histopathology, where Convolutional Neural Networks (CNNs) are used to provide a fast and accurate diagnosis, supporting experts in this task. To perform an automatic diagnosis, prostate tissue samples are first digitized into gigapixel-resolution whole-slide images. Due to the size of these images, neural networks cannot use them as input and, therefore, small subimages called patches are extracted and predicted, obtaining a patch-level classification. In this work, a novel patch aggregation method based on a custom Wide & Deep neural network model is presented, which performs a slide-level classification using the patch-level classes obtained from a CNN. The malignant tissue ratio, a 10-bin malignant probability histogram, the least squares regression line of the histogram, and the number of malignant connected components are used by the proposed model to perform the classification. An accuracy of 94.24% and a sensitivity of 98.87% were achieved, proving that the proposed system could aid pathologists by speeding up the screening process and, thus, contribute to the fight against PCa.

Angel Jimenez-Fernandez, Daniel Gutierrez-Galan, Antonio Rios-Navarro et al.

In neuromorphic engineering, computation is commonly performed asynchronously, mimicking the way in which nervous systems process information: spike by spike. The Neuromorphic Auditory Sensor (NAS) has been implemented under this principle: applying different spike-based Signal Processing blocks. Computation in the spike domain requires the conversion of signals from analog or digital representation to the spike domain, which could present a speed constraint in many cases. This paper presents a spike-based system to convert audio information from low-power pulse density modulation (PDM) MicroElectroMechanical Systems (MEMS) microphones into rate coded spike frequencies. These spikes represent the input signal of the NAS, avoiding the analog or digital to spike conversion, and therefore improving the time response of the NAS. This conversion has been done in VHDL as an interface for PDM microphones, converting their pulses into temporal distributed spikes following a pulse frequency modulation (PFM) scheme with an accurate Inter-Spike-Interval, known as "PDM to spikes interface" (PSI). This was tested in two scenarios, first as a stand-alone circuit for its characterization, and then integrated with a NAS for verification. The PSI achieves a Total Harmonic Distortion (THD) of -39.51dB and a Signal-to-Noise Ratio (SNR) of 59.12dB, demands less than 1\% of the resources of a Spartan-6 FPGA and has a power consumption below 5mW.