Hui‐Kuo G. Shu

Chengfei Lv, Chaoyue Niu, Renjie Gu et al.

To break the bottlenecks of mainstream cloud-based machine learning (ML) paradigm, we adopt device-cloud collaborative ML and build the first end-to-end and general-purpose system, called Walle, as the foundation. Walle consists of a deployment platform, distributing ML tasks to billion-scale devices in time; a data pipeline, efficiently preparing task input; and a compute container, providing a cross-platform and high-performance execution environment, while facilitating daily task iteration. Specifically, the compute container is based on Mobile Neural Network (MNN), a tensor compute engine along with the data processing and model execution libraries, which are exposed through a refined Python thread-level virtual machine (VM) to support diverse ML tasks and concurrent task execution. The core of MNN is the novel mechanisms of operator decomposition and semi-auto search, sharply reducing the workload in manually optimizing hundreds of operators for tens of hardware backends and further quickly identifying the best backend with runtime optimization for a computation graph. The data pipeline introduces an on-device stream processing framework to enable processing user behavior data at source. The deployment platform releases ML tasks with an efficient push-then-pull method and supports multi-granularity deployment policies. We evaluate Walle in practical e-commerce application scenarios to demonstrate its effectiveness, efficiency, and scalability. Extensive micro-benchmarks also highlight the superior performance of MNN and the Python thread-level VM. Walle has been in large-scale production use in Alibaba, while MNN has been open source with a broad impact in the community.

Zach Eidex, Mojtaba Safari, Jacob Wynne et al.

Purpose: Apparent diffusion coefficient (ADC) maps derived from diffusion weighted (DWI) MRI provides functional measurements about the water molecules in tissues. However, DWI is time consuming and very susceptible to image artifacts, leading to inaccurate ADC measurements. This study aims to develop a deep learning framework to synthesize ADC maps from multi-parametric MR images. Methods: We proposed the multiparametric residual vision transformer model (MPR-ViT) that leverages the long-range context of ViT layers along with the precision of convolutional operators. Residual blocks throughout the network significantly increasing the representational power of the model. The MPR-ViT model was applied to T1w and T2- fluid attenuated inversion recovery images of 501 glioma cases from a publicly available dataset including preprocessed ADC maps. Selected patients were divided into training (N=400), validation (N=50) and test (N=51) sets, respectively. Using the preprocessed ADC maps as ground truth, model performance was evaluated and compared against the Vision Convolutional Transformer (VCT) and residual vision transformer (ResViT) models. Results: The results are as follows using T1w + T2-FLAIR MRI as inputs: MPR-ViT - PSNR: 31.0 +/- 2.1, MSE: 0.009 +/- 0.0005, SSIM: 0.950 +/- 0.015. In addition, ablation studies showed the relative impact on performance of each input sequence. Both qualitative and quantitative results indicate that the proposed MR- ViT model performs favorably against the ground truth data. Conclusion: We show that high-quality ADC maps can be synthesized from structural MRI using a MPR- VCT model. Our predicted images show better conformality to the ground truth volume than ResViT and VCT predictions. These high-quality synthetic ADC maps would be particularly useful for disease diagnosis and intervention, especially when ADC maps have artifacts or are unavailable.

Zach Eidex, Mojtaba Safari, Richard L. J. Qiu et al.

Objective: Gadolinium-based contrast agents (GBCAs) are commonly used in MRI scans of patients with gliomas to enhance brain tumor characterization using T1-weighted (T1W) MRI. However, there is growing concern about GBCA toxicity. This study develops a deep-learning framework to generate T1-postcontrast (T1C) from pre-contrast multiparametric MRI. Approach: We propose the tumor-aware vision transformer (TA-ViT) model that predicts high-quality T1C images. The predicted tumor region is significantly improved (P < .001) by conditioning the transformer layers from predicted segmentation maps through adaptive layer norm zero mechanism. The predicted segmentation maps were generated with the multi-parametric residual (MPR) ViT model and transformed into a latent space to produce compressed, feature-rich representations. The TA-ViT model predicted T1C MRI images of 501 glioma cases. Selected patients were split into training (N=400), validation (N=50), and test (N=51) sets. Main Results: Both qualitative and quantitative results demonstrate that the TA-ViT model performs superior against the benchmark MRP-ViT model. Our method produces synthetic T1C MRI with high soft tissue contrast and more accurately reconstructs both the tumor and whole brain volumes. The synthesized T1C images achieved remarkable improvements in both tumor and healthy tissue regions compared to the MRP-ViT model. For healthy tissue and tumor regions, the results were as follows: NMSE: 8.53 +/- 4.61E-4; PSNR: 31.2 +/- 2.2; NCC: 0.908 +/- .041 and NMSE: 1.22 +/- 1.27E-4, PSNR: 41.3 +/- 4.7, and NCC: 0.879 +/- 0.042, respectively. Significance: The proposed method generates synthetic T1C images that closely resemble real T1C images. Future development and application of this approach may enable contrast-agent-free MRI for brain tumor patients, eliminating the risk of GBCA toxicity and simplifying the MRI scan protocol.

Yeming Gu, Hui Shu, Fei Kang et al.

Binary code similarity detection (BCSD) is widely used in various binary analysis tasks such as vulnerability search, malware detection, clone detection, and patch analysis. Recent studies have shown that the learning-based binary code embedding models perform better than the traditional feature-based approaches. However, previous studies have not delved deeply into the key factors that affect model performance. In this paper, we design extensive ablation studies to explore these influencing factors. The experimental results have provided us with many new insights. We have made innovations in both code representation and model selection: we propose a novel rich-semantic function representation technique to ensure the model captures the intricate nuances of binary code, and we introduce the first UniLM-based binary code embedding model, named UniASM, which includes two newly designed training tasks to learn representations of binary functions. The experimental results show that UniASM outperforms the state-of-the-art (SOTA) approaches on the evaluation datasets. The average scores of Recall@1 on cross-compilers, cross-optimization-levels, and cross-obfuscations have improved by 12.7%, 8.5%, and 22.3%, respectively, compared to the best of the baseline methods. Besides, in the real-world task of known vulnerability search, UniASM outperforms all the current baselines.

Zach Eidex, Mojtaba Safari, Jie Ding et al.

Objective: Gadolinium-based contrast agents (GBCAs) are commonly employed with T1w MRI to enhance lesion visualization but are restricted in patients at risk of nephrogenic systemic fibrosis and variations in GBCA administration can introduce imaging inconsistencies. This study develops an efficient 3D deep-learning framework to generate T1-contrast enhanced images (T1C) from pre-contrast multiparametric MRI. Approach: We propose the 3D latent rectified flow (T1C-RFlow) model for generating high-quality T1C images. First, T1w and T2-FLAIR images are input into a pretrained autoencoder to acquire an efficient latent space representation. A rectified flow diffusion model is then trained in this latent space representation. The T1C-RFlow model was trained on a curated dataset comprised of the BraTS 2024 glioma (GLI; 1480 patients), meningioma (MEN; 1141 patients), and metastases (MET; 1475 patients) datasets. Selected patients were split into train (N=2860), validation (N=612), and test (N=614) sets. Results: Both qualitative and quantitative results demonstrate that the T1C-RFlow model outperforms benchmark 3D models (pix2pix, DDPM, Diffusion Transformers (DiT-3D)) trained in the same latent space. T1C-RFlow achieved the following metrics - GLI: NMSE 0.044 +/- 0.047, SSIM 0.935 +/- 0.025; MEN: NMSE 0.046 +/- 0.029, SSIM 0.937 +/- 0.021; MET: NMSE 0.098 +/- 0.088, SSIM 0.905 +/- 0.082. T1C-RFlow had the best tumor reconstruction performance and significantly faster denoising times (6.9 s/volume, 200 steps) than conventional DDPM models in both latent space (37.7s, 1000 steps) and patch-based in image space (4.3 hr/volume). Significance: Our proposed method generates synthetic T1C images that closely resemble ground truth T1C in much less time than previous diffusion models. Further development may permit a practical method for contrast-agent-free MRI for brain tumors.

Yeming Gu, Hui Shu, Rongkuan Ma et al.

The security research on Windows has received little attention in the academic circle. Most of the new methods are usually designed for Linux system, and are difficult to transplant to Windows. Fuzzing for Windows programs always suffering from its closed source. Therefore, we need to find an appropriate way to achieve feedback from Windows programs. To our knowledge, there are no stable and scalable static instrumentation tools for Windows yet, and dynamic tools, such as DynamoRIO, have been criticized for their performance. To make matters worse, dynamic instrumentation tools have very limited usage scenarios and are impotent for many system services or large commercial software. In this paper, we proposed spotInstr, a novel static tool for instrumenting Windows binaries. It is lightweight and can instrument most Windows PE programs in a very short time. At the same time, spotInstr provides a set of filters, which can be used to select instrumentation points or restrict the target regions. Based on these filters, we propose a novel memory-sensitive instrumentation method which can speed up both instrumentation and fuzzing. After that, we design a system called spotFuzzer, which leverage the ability of spotInstr and can fuzz most Windows binaries. We tested spotInstr and spotFuzzer in multiple dimensions to show their superior performance and stability.