David A. Moore

Adalberto Claudio Quiros, Nicolas Coudray, Anna Yeaton et al.

Definitive cancer diagnosis and management depend upon the extraction of information from microscopy images by pathologists. These images contain complex information requiring time-consuming expert human interpretation that is prone to human bias. Supervised deep learning approaches have proven powerful for classification tasks, but they are inherently limited by the cost and quality of annotations used for training these models. To address this limitation of supervised methods, we developed Histomorphological Phenotype Learning (HPL), a fully blue{self-}supervised methodology that requires no expert labels or annotations and operates via the automatic discovery of discriminatory image features in small image tiles. Tiles are grouped into morphologically similar clusters which constitute a library of histomorphological phenotypes, revealing trajectories from benign to malignant tissue via inflammatory and reactive phenotypes. These clusters have distinct features which can be identified using orthogonal methods, linking histologic, molecular and clinical phenotypes. Applied to lung cancer tissues, we show that they align closely with patient survival, with histopathologically recognised tumor types and growth patterns, and with transcriptomic measures of immunophenotype. We then demonstrate that these properties are maintained in a multi-cancer study. These results show the clusters represent recurrent host responses and modes of tumor growth emerging under natural selection. Code, pre-trained models, learned embeddings, and documentation are available to the community at https://github.com/AdalbertoCq/Histomorphological-Phenotype-Learning

Tongzhou Wang, Yi Wu, David A. Moore et al.

Effective implementations of sampling-based probabilistic inference often require manually constructed, model-specific proposals. Inspired by recent progresses in meta-learning for training learning agents that can generalize to unseen environments, we propose a meta-learning approach to building effective and generalizable MCMC proposals. We parametrize the proposal as a neural network to provide fast approximations to block Gibbs conditionals. The learned neural proposals generalize to occurrences of common structural motifs across different models, allowing for the construction of a library of learned inference primitives that can accelerate inference on unseen models with no model-specific training required. We explore several applications including open-universe Gaussian mixture models, in which our learned proposals outperform a hand-tuned sampler, and a real-world named entity recognition task, in which our sampler yields higher final F1 scores than classical single-site Gibbs sampling.

David A. Moore, Stuart J. Russell

Detecting weak seismic events from noisy sensors is a difficult perceptual task. We formulate this task as Bayesian inference and propose a generative model of seismic events and signals across a network of spatially distributed stations. Our system, SIGVISA, is the first to directly model seismic waveforms, allowing it to incorporate a rich representation of the physics underlying the signal generation process. We use Gaussian processes over wavelet parameters to predict detailed waveform fluctuations based on historical events, while degrading smoothly to simple parametric envelopes in regions with no historical seismicity. Evaluating on data from the western US, we recover three times as many events as previous work, and reduce mean location errors by a factor of four while greatly increasing sensitivity to low-magnitude events.

Jun Song, David A. Moore

We introduce a novel approach for parallelizing MCMC inference in models with spatially determined conditional independence relationships, for which existing techniques exploiting graphical model structure are not applicable. Our approach is motivated by a model of seismic events and signals, where events detected in distant regions are approximately independent given those in intermediate regions. We perform parallel inference by coloring a factor graph defined over regions of latent space, rather than individual model variables. Evaluating on a model of seismic event detection, we achieve significant speedups over serial MCMC with no degradation in inference quality.

David A. Moore, Stuart J. Russell

Gaussian processes have been successful in both supervised and unsupervised machine learning tasks, but their computational complexity has constrained practical applications. We introduce a new approximation for large-scale Gaussian processes, the Gaussian Process Random Field (GPRF), in which local GPs are coupled via pairwise potentials. The GPRF likelihood is a simple, tractable, and parallelizeable approximation to the full GP marginal likelihood, enabling latent variable modeling and hyperparameter selection on large datasets. We demonstrate its effectiveness on synthetic spatial data as well as a real-world application to seismic event location.