Reza Khoshkangini

Zahra Asghari Varzaneh, Niclas Wölner-Hanssen, Reza Khoshkangini et al.

The selection of the optimal embryo for transfer is a critical yet challenging step in in vitro fertilization (IVF), primarily due to its reliance on the manual inspection of extensive time-lapse imaging data. A key obstacle in this process is predicting blastocyst formation from the limited number of daily images available. Many clinics also lack complete time-lapse systems, so full videos are often unavailable. In this study, we aimed to predict which embryos will develop into blastocysts using limited daily images from time-lapse recordings. We propose a novel hybrid model that combines DINOv2, a transformer-based vision model, with an enhanced long short-term memory (LSTM) network featuring a multi-head attention layer. DINOv2 extracts meaningful features from embryo images, and the LSTM model then uses these features to analyze embryo development over time and generate final predictions. We tested our model on a real dataset of 704 embryo videos. The model achieved 96.4% accuracy, surpassing existing methods. It also performs well with missing frames, making it valuable for many IVF laboratories with limited imaging systems. Our approach can assist embryologists in selecting better embryos more efficiently and with greater confidence.

Nahid Khoshk Angabini, Mohsen Tajgardan, Mahesh Madhavan et al.

Reliable evaluation of blastocyst quality is critical for the success of in vitro fertilization (IVF) treatments. Current embryo grading practices primarily rely on visual assessment of morphological features, which introduces subjectivity, inter-embryologist variability, and challenges in standardizing quality assurance. In this study, we propose a multitask embedding-based approach for the automated analysis and prediction of key blastocyst components, including the trophectoderm (TE), inner cell mass (ICM), and blastocyst expansion (EXP). The method leverages biological and physical characteristics extracted from images of day-5 human embryos. A pretrained ResNet-18 architecture, enhanced with an embedding layer, is employed to learn discriminative representations from a limited dataset and to automatically identify TE and ICM regions along with their corresponding grades, structures that are visually similar and inherently difficult to distinguish. Experimental results demonstrate the promise of the multitask embedding approach and potential for robust and consistent blastocyst quality assessment.

Zahra Asghari Varzaneh, Reza Khoshkangini, Magnus Johnsson et al.

This study introduces Blasto-Net, a multi-task deep learning model for comprehensive blastocyst analysis. The proposed model performs three tasks simultaneously in a single forward pass: segmentation of the ZP, TE, and ICM compartments, morphological grading, and implantation outcome prediction. Accurate blastocyst analysis in in vitro fertilization (IVF) is challenging. The compartments often have similar textures but very different structures. To address these challenges, Blasto-Net employs an EfficientNet-B3 encoder with a UNet-style decoder enhanced by the Convolutional Block Attention Module (CBAM) and a novel Edge-Aware Attention Module (EAAM) to effectively capture both semantic and boundary information. To handle distinct compartment topologies, the network employs specialized segmentation heads and a composite region- and boundary-based loss. Additionally, Grad-CAM++ visualizations are used to verify the anatomical consistency of the model's predictions. Evaluated on a public HMC blastocyst dataset, Blasto-Net achieves Dice scores of 94.93%, 91.60%, and 88.82% for ICM, ZP, and TE, respectively, alongside an implantation F1-score of 80.0%. These results demonstrate that Blasto-Net offers an accurate, interpretable, and efficient solution for automated blastocyst assessment, with strong potential to support clinical decision-making in IVF.

Zahra Asghari Varzaneh, Reza Khoshkangini, Thomas Ebner et al.

Male infertility is a major cause of couple infertility, often linked to abnormal sperm morphology. While deep learning models offer automated analysis, most lack interpretability, limiting their clinical adoption. This study proposes an attention-guided deep learning framework for sperm morphology classification. We combine a pretrained EfficientNet-B0 with a Convolutional Block Attention Module (CBAM) to focus on key areas of the sperm head, improving both accuracy and interpretability. Evaluated on the SMIDS and HuSHem public datasets, our model achieves accuracies of 90.2% and 93.9% (macro F1 scores of 0.913 and 0.948), outperforming SimpleCNN and standard EfficientNet-B0. Furthermore, we use Grad-CAM++ visualizations to highlight features influencing the model's decisions. The results demonstrate that this accurate and transparent framework is a practical tool for automated sperm analysis in fertility clinics.

Zahra Asghari Varzaneh, Reza Khoshkangini, Pia Saldeen et al.

IVF pregnancy rates are routinely modeled using patient-level variables, while high-resolution laboratory environmental data remain underutilized. We show that this is a missed opportunity. Rather than relying on raw sensor averages, we engineer 55 context-aware temporal features, including rolling thermal stability, simultaneous temperature-humidity adherence, peak stress duration, and post-stress recovery speed, that capture the dynamics of incubator microenvironments. On 61 weeks of data from an Asian IVF clinic, these features reduce cross-validated prediction error to 1.27%, compared to 3-5% for raw averages. We then train a hierarchical Bayesian Beta regression model that shares environmental effects across an Asian and a Northern European clinic via partial pooling, while preserving site-specific baselines. On held-out data from the Northern European clinic, the model achieves R2 = 0.86 and a 64% error reduction for the 35-39 age group over a naive baseline, demonstrating that structured environmental monitoring contains clinically meaningful, transferable signal.

Mahtab Jamali, Paul Davidsson, Reza Khoshkangini et al.

Context is an important factor in computer vision as it offers valuable information to clarify and analyze visual data. Utilizing the contextual information inherent in an image or a video can improve the precision and effectiveness of object detectors. For example, where recognizing an isolated object might be challenging, context information can improve comprehension of the scene. This study explores the impact of various context-based approaches to object detection. Initially, we investigate the role of context in object detection and survey it from several perspectives. We then review and discuss the most recent context-based object detection approaches and compare them. Finally, we conclude by addressing research questions and identifying gaps for further studies. More than 265 publications are included in this survey, covering different aspects of context in different categories of object detection, including general object detection, video object detection, small object detection, camouflaged object detection, zero-shot, one-shot, and few-shot object detection. This literature review presents a comprehensive overview of the latest advancements in context-based object detection, providing valuable contributions such as a thorough understanding of contextual information and effective methods for integrating various context types into object detection, thus benefiting researchers.

Mohsen Tajgardan, Atena Shiranzaei, Mahdi Rabbani et al.

Federated learning (FL) is an effective paradigm for distributed environments such as the Internet of Things (IoT), where data from diverse devices with varying functionalities remains localized while contributing to a shared global model. By eliminating the need to transmit raw data, FL inherently preserves privacy. However, the heterogeneous nature of IoT data, stemming from differences in device capabilities, data formats, and communication constraints, poses significant challenges to maintaining both global model performance and privacy. In the context of IoT-based anomaly detection, unsupervised FL offers a promising means to identify abnormal behavior without centralized data aggregation. Nevertheless, feature heterogeneity across devices complicates model training and optimization, hindering effective implementation. In this study we propose an efficient unsupervised FL framework that enhances anomaly detection by leveraging shared features from two distinct IoT datasets: one focused on anomaly detection and the other on device identification, while preserving dataset-specific features. To improve transparency and interpretability, we employ explainable AI techniques, such as SHAP, to identify key features influencing local model decisions. Experiments conducted on real-world IoT datasets demonstrate that the proposed method significantly outperforms conventional FL approaches in anomaly detection accuracy. This work underscores the potential of using shared features from complementary datasets to optimize unsupervised federated learning and achieve superior anomaly detection results in decentralized IoT environments.