Ling Zhang

Ling Zhang, Zhigang Zhu

To alleviate the cost of collecting and annotating large-scale point cloud datasets, we propose an unsupervised learning approach to learn features from unlabeled point cloud "3D object" dataset by using part contrasting and object clustering with deep graph neural networks (GNNs). In the contrast learning step, all the samples in the 3D object dataset are cut into two parts and put into a "part" dataset. Then a contrast learning GNN (ContrastNet) is trained to verify whether two randomly sampled parts from the part dataset belong to the same object. In the cluster learning step, the trained ContrastNet is applied to all the samples in the original 3D object dataset to extract features, which are used to group the samples into clusters. Then another GNN for clustering learning (ClusterNet) is trained to predict the cluster ID of all the training samples. The contrasting learning forces the ContrastNet to learn high-level semantic features of objects but probably ignores low-level features, while the ClusterNet improves the quality of learned features by being trained to discover objects that probably belong to the same semantic categories by the use of cluster IDs. We have conducted extensive experiments to evaluate the proposed framework on point cloud classification tasks. The proposed unsupervised learning approach obtained comparable performance to the state-of-the-art unsupervised learning methods that used much more complicated network structures. The code of this work is publicly available via: https://github.com/lingzhang1/ContrastNet.

Zhongyi Shui, Jianpeng Zhang, Weiwei Cao et al.

Artificial intelligence (AI) shows great potential in assisting radiologists to improve the efficiency and accuracy of medical image interpretation and diagnosis. However, a versatile AI model requires large-scale data and comprehensive annotations, which are often impractical in medical settings. Recent studies leverage radiology reports as a naturally high-quality supervision for medical images, using contrastive language-image pre-training (CLIP) to develop language-informed models for radiological image interpretation. Nonetheless, these approaches typically contrast entire images with reports, neglecting the local associations between imaging regions and report sentences, which may undermine model performance and interoperability. In this paper, we propose a fine-grained vision-language model (fVLM) for anatomy-level CT image interpretation. Specifically, we explicitly match anatomical regions of CT images with corresponding descriptions in radiology reports and perform contrastive pre-training for each anatomy individually. Fine-grained alignment, however, faces considerable false-negative challenges, mainly from the abundance of anatomy-level healthy samples and similarly diseased abnormalities. To tackle this issue, we propose identifying false negatives of both normal and abnormal samples and calibrating contrastive learning from patient-level to disease-aware pairing. We curated the largest CT dataset to date, comprising imaging and report data from 69,086 patients, and conducted a comprehensive evaluation of 54 major and important disease diagnosis tasks across 15 main anatomies. Experimental results demonstrate the substantial potential of fVLM in versatile medical image interpretation. In the zero-shot classification task, we achieved an average AUC of 81.3% on 54 diagnosis tasks, surpassing CLIP and supervised methods by 12.9% and 8.0%, respectively.