Vikram Singh

Amazon AGI, Aaron Langford, Aayush Shah et al. · amazon-science

We present Amazon Nova, a new generation of state-of-the-art foundation models that deliver frontier intelligence and industry-leading price performance. Amazon Nova Pro is a highly-capable multimodal model with the best combination of accuracy, speed, and cost for a wide range of tasks. Amazon Nova Lite is a low-cost multimodal model that is lightning fast for processing images, video, documents and text. Amazon Nova Micro is a text-only model that delivers our lowest-latency responses at very low cost. Amazon Nova Canvas is an image generation model that creates professional grade images with rich customization controls. Amazon Nova Reel is a video generation model offering high-quality outputs, customization, and motion control. Our models were built responsibly and with a commitment to customer trust, security, and reliability. We report benchmarking results for core capabilities, agentic performance, long context, functional adaptation, runtime performance, and human evaluation.

Vikram Singh, Vikram Singh

Neoplasms (NPs) and neurological diseases and disorders (NDDs) are amongst the major classes of diseases underlying deaths of a disproportionate number of people worldwide. To determine if there exist some distinctive features in the local wiring patterns of protein interactions emerging at the onset of a disease belonging to either of these two classes, we examined 112 and 175 protein interaction networks belonging to NPs and NDDs, respectively. Orbit usage profiles (OUPs) for each of these networks were enumerated by investigating the networks' local topology. 56 non-redundant OUPs (nrOUPs) were derived and used as network features for classification between these two disease classes. Four machine learning classifiers, namely, k-nearest neighbour (KNN), support vector machine (SVM), deep neural network (DNN), random forest (RF) were trained on these data. DNN obtained the greatest average AUPRC (0.988) among these classifiers. DNNs developed on node2vec and the proposed nrOUPs embeddings were compared using 5-fold cross validation on the basis of average values of the six of performance measures, viz., AUPRC, Accuracy, Sensitivity, Specificity, Precision and MCC. It was found that nrOUPs based classifier performed better in all of these six performance measures.

Vikram Singh, Vikram Singh

The enormous diversity of life forms thriving in drastically different environmental milieus involves a complex interplay among constituent proteins interacting with each other. However, the organizational principles characterizing the evolution of protein interaction networks (PINs) across the tree of life are largely unknown. Here we study 4,738 PINs belonging to 16 phyla to discover phyla-specific architectural features and examine if there are some evolutionary constraints imposed on the networks' topologies. We utilized positional information of a network's nodes by normalizing the frequencies of automorphism orbits appearing in graphlets of sizes 2-5. We report that orbit usage profiles (OUPs) of networks belonging to the three domains of life are contrastingly different not only at the domain level but also at the scale of phyla. Integrating the information related to protein families, domains, subcellular location, gene ontology, and pathways, our results indicate that wiring patterns of PINs in different phyla are not randomly generated rather they are shaped by evolutionary constraints imposed on them. There exist subtle but substantial variations in the wiring patterns of PINs that enable OUPs to differentiate among different superfamilies. A deep neural network was trained on differentially expressed orbits resulting in a prediction accuracy of 85%.

Adriana Aida, Walida Amer, Katarina Bankovic et al.

Industrial robotic manipulation demands reliable long-horizon execution across embodiments, tasks, and changing object distributions. While Vision-Language-Action models have demonstrated strong generalization, they remain fundamentally reactive. By optimizing the next action given the current observation without evaluating potential futures, they are brittle to the compounding failure modes of long-horizon tasks. Cortex 2.0 shifts from reactive control to plan-and-act by generating candidate future trajectories in visual latent space, scoring them for expected success and efficiency, then committing only to the highest-scoring candidate. We evaluate Cortex 2.0 on a single-arm and dual-arm manipulation platform across four tasks of increasing complexity: pick and place, item and trash sorting, screw sorting, and shoebox unpacking. Cortex 2.0 consistently outperforms state-of-the-art Vision-Language-Action baselines, achieving the best results across all tasks. The system remains reliable in unstructured environments characterized by heavy clutter, frequent occlusions, and contact-rich manipulation, where reactive policies fail. These results demonstrate that world-model-based planning can operate reliably in complex industrial environments.

Holger R. Roth, Sarthak Tickoo, Mayank Kumar et al.

Fraud-related financial losses continue to rise, while regulatory, privacy, and data-sovereignty constraints increasingly limit the feasibility of centralized fraud detection systems. Federated Learning (FL) has emerged as a promising paradigm for enabling collaborative model training across institutions without sharing raw transaction data. Yet, its practical effectiveness under realistic, non-IID financial data distributions remains insufficiently validated. In this work, we present a multi-institution, industry-oriented proof-of-concept study evaluating federated anomaly detection for payment transactions using the NVIDIA FLARE framework. We simulate a realistic federation of heterogeneous financial institutions, each observing distinct fraud typologies and operating under strict data isolation. Using a deep neural network trained via federated averaging (FedAvg), we demonstrate that federated models achieve a mean F1-score of 0.903 - substantially outperforming locally trained models (0.643) and closely approaching centralized training performance (0.925), while preserving full data sovereignty. We further analyze convergence behavior, showing that strong performance is achieved within 10 federated communication rounds, highlighting the operational viability of FL in latency- and cost-sensitive financial environments. To support deployment in regulated settings, we evaluate model interpretability using Shapley-based feature attribution and confirm that federated models rely on semantically coherent, domain-relevant decision signals. Finally, we incorporate sample-level differential privacy via DP-SGD and demonstrate favorable privacy-utility trade-offs...

Vikram Singh, Kabir Malhotra, Rohan Desai et al.

Lesion segmentation, in contrast to natural scene segmentation, requires handling subtle variations in texture and color, frequent imaging artifacts (such as hairs, rulers, and bubbles), and a critical need for precise boundary localization to aid in accurate diagnosis. The accurate delineation of melanocytic tumors in dermoscopic images is a crucial component of automated skin cancer screening systems and clinical decision support. In this paper, we present a novel dual-resolution architecture inspired by ResNet, specifically tailored for the segmentation of melanocytic tumors. Our approach incorporates a high-resolution stream that preserves fine boundary details, alongside a complementary pooled stream that captures multi-scale contextual information for robust lesion recognition. These two streams are closely integrated through boundary-aware residual connections, which inject edge information into deep feature maps, and a channel attention mechanism that adapts the model's sensitivity to color and texture variations in dermoscopic images. To tackle common imaging artifacts and the challenges posed by small clinical datasets, we introduce a lightweight artifact suppression block and a multi-task training strategy. This strategy combines the Dice-Tversky loss with an explicit boundary loss and a contrastive regularizer to enhance feature stability. This unified design enables the model to generate pixel-accurate segmentation masks without the need for extensive post-processing or complex pre-training. Extensive evaluation on public dermoscopic benchmarks reveals that our method significantly enhances boundary precision and clinically relevant segmentation metrics, outperforming traditional encoder-decoder baselines. This makes our approach a valuable component for building automated melanoma assessment systems.

Aarav Mehta, Priya Deshmukh, Vikram Singh et al.

Accurate localization of organ boundaries is critical in medical imaging for segmentation, registration, surgical planning, and radiotherapy. While deep convolutional networks (ConvNets) have advanced general-purpose edge detection to near-human performance on natural images, their outputs often lack precise localization, a limitation that is particularly harmful in medical applications where millimeter-level accuracy is required. Building on a systematic analysis of ConvNet edge outputs, we propose a medically focused crisp edge detector that adapts a novel top-down backward refinement architecture to medical images (2D and volumetric). Our method progressively upsamples and fuses high-level semantic features with fine-grained low-level cues through a backward refinement pathway, producing high-resolution, well-localized organ boundaries. We further extend the design to handle anisotropic volumes by combining 2D slice-wise refinement with light 3D context aggregation to retain computational efficiency. Evaluations on several CT and MRI organ datasets demonstrate substantially improved boundary localization under strict criteria (boundary F-measure, Hausdorff distance) compared to baseline ConvNet detectors and contemporary medical edge/contour methods. Importantly, integrating our crisp edge maps into downstream pipelines yields consistent gains in organ segmentation (higher Dice scores, lower boundary errors), more accurate image registration, and improved delineation of lesions near organ interfaces. The proposed approach produces clinically valuable, crisp organ edges that materially enhance common medical-imaging tasks.

Vikram Singh, Min Sun

Best subset selection in linear regression is well known to be nonconvex and computationally challenging to solve, as the number of possible subsets grows rapidly with increasing dimensionality of the problem. As a result, finding the global optimal solution via an exact optimization method for a problem with dimensions of 1000s may take an impractical amount of CPU time. This suggests the importance of finding suboptimal procedures that can provide good approximate solutions using much less computational effort than exact methods. In this work, we introduce a new procedure and compare it with other popular suboptimal algorithms to solve the best subset selection problem. Extensive computational experiments using synthetic and real data have been performed. The results provide insights into the performance of these methods in different data settings. The new procedure is observed to be a competitive suboptimal algorithm for solving the best subset selection problem for high-dimensional data.

Vikram Singh, Anurag Mittal

Divide and conquer is an established algorithm design paradigm that has proven itself to solve a variety of problems efficiently. However, it is yet to be fully explored in solving problems with a neural network, particularly the problem of image super-resolution. In this work, we propose an approach to divide the problem of image super-resolution into multiple sub-problems and then solve/conquer them with the help of a neural network. Unlike a typical deep neural network, we design an alternate network architecture that is much wider (along with being deeper) than existing networks and is specially designed to implement the divide-and-conquer design paradigm with a neural network. Additionally, a technique to calibrate the intensities of feature map pixels is being introduced. Extensive experimentation on five datasets reveals that our approach towards the problem and the proposed architecture generate better and sharper results than current state-of-the-art methods.