Andreas Maier

Paul A. Constable, Dorothy A. Thompson, Irene O. Lee et al.

The LEOPs (Light-ERG-Oscillatory Potentials) dataset provides light-adapted (LA) electroretinogram (ERG) and Oscillatory Potentials (OPs) waveforms for typically developing Control, Autism Spectrum Disorder (ASD) and ASD + Attention Deficit Hyperactivity Disorder (ADHD) childhood and adolescent populations. The ERGs were recorded in the Right And Left eyes with skin electrodes using the handheld RETeval device at two sites in Australia and the United Kingdom. The LEOPs dataset includes 5309 single flash ERG and 4434 OPs waveforms as well as images selected from each participant showing the position of the skin electrode. The LEOPs dataset is constructed from recordings using a 9 step randomized flash series from $-0.37$ to $1.20$~$Td.s$, a 2 step at 113 and 446 $Td.s$ flash strengths (2500 Control, 1730 ASD and 451 ASD + ADHD samples), as well as the $85$~$Td.s$ (Light Adapted 3 $cd.s.m^{-2}$ (LA3)) equivalent International Society of Clinical Electrophysiology of Vision (ISCEV) Standard flash with 435 Control, 176 ASD and 37 ASD + ADHD waveform samples. Code for the stimulus is provided along with participant demographics, date and time of testing, and where available diagnostic scores for the ASD and ASD + ADHD groups, alongside iris color, electrode position with image files and time domain values for the ERG and summed values for the OPs. The repository contains excel file, exported JSON files on the patient level that are more suitable for machine learning tasks, images of electrode position for each recording and the protocol files for use with the RETeval.

Fei Wu, Nora Gourmelon, Thorsten Seehaus et al.

Knowledge on changes in glacier calving front positions is important for assessing the status of glaciers. Remote sensing imagery provides the ideal database for monitoring calving front positions, however, it is not feasible to perform this task manually for all calving glaciers globally due to time-constraints. Deep learning-based methods have shown great potential for glacier calving front delineation from optical and radar satellite imagery. The calving front is represented as a single thin line between the ocean and the glacier, which makes the task vulnerable to inaccurate predictions. The limited availability of annotated glacier imagery leads to a lack of data diversity (not all possible combinations of different weather conditions, terminus shapes, sensors, etc. are present in the data), which exacerbates the difficulty of accurate segmentation. In this paper, we propose Attention-Multi-hooking-Deep-supervision HookNet (AMD-HookNet), a novel glacier calving front segmentation framework for synthetic aperture radar (SAR) images. The proposed method aims to enhance the feature representation capability through multiple information interactions between low-resolution and high-resolution inputs based on a two-branch U-Net. The attention mechanism, integrated into the two branch U-Net, aims to interact between the corresponding coarse and fine-grained feature maps. This allows the network to automatically adjust feature relationships, resulting in accurate pixel-classification predictions. Extensive experiments and comparisons on the challenging glacier segmentation benchmark dataset CaFFe show that our AMD-HookNet achieves a mean distance error of 438 m to the ground truth outperforming the current state of the art by 42%, which validates its effectiveness.

Mayank Patwari, Ralf Gutjahr, Rainer Raupach et al.

The use of deep learning has successfully solved several problems in the field of medical imaging. Deep learning has been applied to the CT denoising problem successfully. However, the use of deep learning requires large amounts of data to train deep convolutional networks (CNNs). Moreover, due to large parameter count, such deep CNNs may cause unexpected results. In this study, we introduce a novel CT denoising framework, which has interpretable behaviour, and provides useful results with limited data. We employ bilateral filtering in both the projection and volume domains to remove noise. To account for non-stationary noise, we tune the $σ$ parameters of the volume for every projection view, and for every volume pixel. The tuning is carried out by two deep CNNs. Due to impracticality of labelling, the two deep CNNs are trained via a Deep-Q reinforcement learning task. The reward for the task is generated by using a custom reward function represented by a neural network. Our experiments were carried out on abdominal scans for the Mayo Clinic TCIA dataset, and the AAPM Low Dose CT Grand Challenge. Our denoising framework has excellent denoising performance increasing the PSNR from 28.53 to 28.93, and increasing the SSIM from 0.8952 to 0.9204. We outperform several state-of-the-art deep CNNs, which have several orders of magnitude higher number of parameters (p-value (PSNR) = 0.000, p-value (SSIM) = 0.000). Our method does not introduce any blurring, which is introduced by MSE loss based methods, or any deep learning artifacts, which are introduced by WGAN based models. Our ablation studies show that parameter tuning and using our reward network results in the best possible results.

Achim Schilling, William Sedley, Richard Gerum et al.

How is information processed in the brain during perception? Mechanistic insight is achieved only when experiments are employed to test formal or computational models. In analogy to lesion studies, phantom perception may serve as a vehicle to understand the fundamental processing principles underlying auditory perception. With a special focus on tinnitus -- as the prime example of auditory phantom perception -- we review recent work at the intersection of artificial intelligence, psychology, and neuroscience. In particular, we discuss why everyone with tinnitus suffers from hearing loss, but not everyone with hearing loss suffers from tinnitus. We argue that the increase of sensory precision due to Bayesian inference could be caused by intrinsic neural noise and lead to a prediction error in the cerebral cortex. Hence, two fundamental processing principles - being ubiquitous in the brain - provide the most explanatory power for the emergence of tinnitus: predictive coding as a top-down, and stochastic resonance as a complementary bottom-up mechanism. We conclude that both principles play a crucial role in healthy auditory perception.

Fuxin Fan, Ludwig Ritschl, Marcel Beister et al.

In several image acquisition and processing steps of X-ray radiography, knowledge of the existence of metal implants and their exact position is highly beneficial (e.g. dose regulation, image contrast adjustment). Another application which would benefit from an accurate metal segmentation is cone beam computed tomography (CBCT) which is based on 2D X-ray projections. Due to the high attenuation of metals, severe artifacts occur in the 3D X-ray acquisitions. The metal segmentation in CBCT projections usually serves as a prerequisite for metal artifact avoidance and reduction algorithms. Since the generation of high quality clinical training is a constant challenge, this study proposes to generate simulated X-ray images based on CT data sets combined with self-designed computer aided design (CAD) implants and make use of convolutional neural network (CNN) and vision transformer (ViT) for metal segmentation. Model test is performed on accurately labeled X-ray test datasets obtained from specimen scans. The CNN encoder-based network like U-Net has limited performance on cadaver test data with an average dice score below 0.30, while the metal segmentation transformer with dual decoder (MST-DD) shows high robustness and generalization on the segmentation task, with an average dice score of 0.90. Our study indicates that the CAD model-based data generation has high flexibility and could be a way to overcome the problem of shortage in clinical data sampling and labelling. Furthermore, the MST-DD approach generates a more reliable neural network in case of training on simulated data.

Vincent Christlein, David Bernecker, Andreas Maier et al.

Convolutional neural networks (CNNs) have recently become the state-of-the-art tool for large-scale image classification. In this work we propose the use of activation features from CNNs as local descriptors for writer identification. A global descriptor is then formed by means of GMM supervector encoding, which is further improved by normalization with the KL-Kernel. We evaluate our method on two publicly available datasets: the ICDAR 2013 benchmark database and the CVL dataset. While we perform comparably to the state of the art on CVL, our proposed method yields about 0.21 absolute improvement in terms of mAP on the challenging bilingual ICDAR dataset.

Martin Mayr, Julian Krenz, Katharina Neumeier et al.

Most datasets in the field of document analysis utilize highly standardized labels, which, while simplifying specific tasks, often produce outputs that are not directly applicable to humanities research. In contrast, the Nuremberg Letterbooks dataset, which comprises historical documents from the early 15th century, addresses this gap by providing multiple types of transcriptions and accompanying metadata. This approach allows for developing methods that are more closely aligned with the needs of the humanities. The dataset includes 4 books containing 1711 labeled pages written by 10 scribes. Three types of transcriptions are provided for handwritten text recognition: Basic, diplomatic, and regularized. For the latter two, versions with and without expanded abbreviations are also available. A combination of letter ID and writer ID supports writer identification due to changing writers within pages. In the technical validation, we established baselines for various tasks, demonstrating data consistency and providing benchmarks for future research to build upon.

Badhan Kumar Das, Ajay Singh, Saahil Islam et al.

The Transformer architecture has opened a new paradigm in the domain of deep learning with its ability to model long-range dependencies and capture global context and has outpaced the traditional Convolution Neural Networks (CNNs) in many aspects. However, applying Transformer models to 3D medical image datasets presents significant challenges due to their high training time, and memory requirements, which not only hinder scalability but also contribute to elevated CO$_2$ footprint. This has led to an exploration of alternative models that can maintain or even improve performance while being more efficient and environmentally sustainable. Recent advancements in Structured State Space Models (SSMs) effectively address some of the inherent limitations of Transformers, particularly their high memory and computational demands. Inspired by these advancements, we propose an efficient 3D segmentation model for medical imaging called SegResMamba, designed to reduce computation complexity, memory usage, training time, and environmental impact while maintaining high performance. Our model uses less than half the memory during training compared to other state-of-the-art (SOTA) architectures, achieving comparable performance with significantly reduced resource demands.

Simon Süwer, Kester Bagemihl, Sylvie Baier et al.

Repurposing approved drugs offers a time-efficient and cost-effective alternative to traditional drug development. However, in silico prediction of repurposing candidates is challenging and requires the effective collaboration of specialists in various fields, including pharmacology, medicine, biology, and bioinformatics. Fragmented, specialized algorithms and tools often address only narrow aspects of the overall problem. Heterogeneous, unstructured data landscapes require the expertise of specialized users. Hence, these data services do not integrate smoothly across workflows. With ChatDRex, we present a conversation-based, multi-agent system that facilitates the execution of complex bioinformatic analyses aiming for network-based drug repurposing prediction. It builds on the integrated systems medicine knowledge graph (NeDRex KG). ChatDRex provides natural language access to its extensive biomedical knowledge base. It integrates bioinformatics agents for network analysis, literature mining, and drug repurposing. These are complemented by agents that evaluate functional coherence for in silico validation. Its flexible multi-agent design assigns specific tasks to specialized agents, including query routing, data retrieval, algorithm execution, and result visualization. A dedicated reasoning module keeps the user in the loop and allows for hallucination detection. By enabling physicians and researchers without computer science expertise to control complex analyses with natural language, ChatDRex democratizes access to bioinformatics as an important resource for drug repurposing. It enables clinical experts to generate hypotheses and explore drug repurposing opportunities, ultimately accelerating the discovery of novel therapies and advancing personalized medicine and translational research. ChatDRex is publicly available at apps.cosy.bio/chatdrex.

Badhan Kumar Das, Gengyan Zhao, Boris Mailhe et al.

Identifying brain hemorrhages from magnetic resonance imaging (MRI) is a critical task for healthcare professionals. The diverse nature of MRI acquisitions with varying contrasts and orientation introduce complexity in identifying hemorrhage using neural networks. For acquisitions with varying orientations, traditional methods often involve resampling images to a fixed plane, which can lead to information loss. To address this, we propose a 3D multi-plane vision transformer (MP-ViT) for hemorrhage classification with varying orientation data. It employs two separate transformer encoders for axial and sagittal contrasts, using cross-attention to integrate information across orientations. MP-ViT also includes a modality indication vector to provide missing contrast information to the model. The effectiveness of the proposed model is demonstrated with extensive experiments on real world clinical dataset consists of 10,084 training, 1,289 validation and 1,496 test subjects. MP-ViT achieved substantial improvement in area under the curve (AUC), outperforming the vision transformer (ViT) by 5.5% and CNN-based architectures by 1.8%. These results highlight the potential of MP-ViT in improving performance for hemorrhage detection when different orientation contrasts are needed.

Maja Schlereth, Daniel Stromer, Katharina Breininger et al.

Neuromuscular diseases (NMDs) cause a significant burden for both healthcare systems and society. They can lead to severe progressive muscle weakness, muscle degeneration, contracture, deformity and progressive disability. The NMDs evaluated in this study often manifest in early childhood. As subtypes of disease, e.g. Duchenne Muscular Dystropy (DMD) and Spinal Muscular Atrophy (SMA), are difficult to differentiate at the beginning and worsen quickly, fast and reliable differential diagnosis is crucial. Photoacoustic and ultrasound imaging has shown great potential to visualize and quantify the extent of different diseases. The addition of automatic classification of such image data could further improve standard diagnostic procedures. We compare deep learning-based 2-class and 3-class classifiers based on VGG16 for differentiating healthy from diseased muscular tissue. This work shows promising results with high accuracies above 0.86 for the 3-class problem and can be used as a proof of concept for future approaches for earlier diagnosis and therapeutic monitoring of NMDs.

Rosanna Dietrich-Sussner, Amirabbas Davari, Thorsten Seehaus et al.

Supervised machine learning requires a large amount of labeled data to achieve proper test results. However, generating accurately labeled segmentation maps on remote sensing imagery, including images from synthetic aperture radar (SAR), is tedious and highly subjective. In this work, we propose to alleviate the issue of limited training data by generating synthetic SAR images with the pix2pix algorithm. This algorithm uses conditional Generative Adversarial Networks (cGANs) to generate an artificial image while preserving the structure of the input. In our case, the input is a segmentation mask, from which a corresponding synthetic SAR image is generated. We present different models, perform a comparative study and demonstrate that this approach synthesizes convincing glaciers in SAR images with promising qualitative and quantitative results.

Andreas Hartmann, Amirabbas Davari, Thorsten Seehaus et al.

Fluctuations of the glacier calving front have an important influence over the ice flow of whole glacier systems. It is therefore important to precisely monitor the position of the calving front. However, the manual delineation of SAR images is a difficult, laborious and subjective task. Convolutional neural networks have previously shown promising results in automating the glacier segmentation in SAR images, making them desirable for further exploration of their possibilities. In this work, we propose to compute uncertainty and use it in an Uncertainty Optimization regime as a novel two-stage process. By using dropout as a random sampling layer in a U-Net architecture, we create a probabilistic Bayesian Neural Network. With several forward passes, we create a sampling distribution, which can estimate the model uncertainty for each pixel in the segmentation mask. The additional uncertainty map information can serve as a guideline for the experts in the manual annotation of the data. Furthermore, feeding the uncertainty map to the network leads to 95.24% Dice similarity, which is an overall improvement in the segmentation performance compared to the state-of-the-art deterministic U-Net-based glacier segmentation pipelines.

Michael Holzmann, Amirabbas Davari, Thorsten Seehaus et al.

An essential climate variable to determine the tidewater glacier status is the location of the calving front position and the separation of seasonal variability from long-term trends. Previous studies have proposed deep learning-based methods to semi-automatically delineate the calving fronts of tidewater glaciers. They used U-Net to segment the ice and non-ice regions and extracted the calving fronts in a post-processing step. In this work, we show a method to segment the glacier calving fronts from SAR images in an end-to-end fashion using Attention U-Net. The main objective is to investigate the attention mechanism in this application. Adding attention modules to the state-of-the-art U-Net network lets us analyze the learning process by extracting its attention maps. We use these maps as a tool to search for proper hyperparameters and loss functions in order to generate higher qualitative results. Our proposed attention U-Net performs comparably to the standard U-Net while providing additional insight into those regions on which the network learned to focus more. In the best case, the attention U-Net achieves a 1.5% better Dice score compared to the canonical U-Net with a glacier front line prediction certainty of up to 237.12 meters.

Marc Aubreville, Christof A. Bertram, Samir Jabari et al.

For histopathological tumor assessment, the count of mitotic figures per area is an important part of prognostication. Algorithmic approaches - such as for mitotic figure identification - have significantly improved in recent times, potentially allowing for computer-augmented or fully automatic screening systems in the future. This trend is further supported by whole slide scanning microscopes becoming available in many pathology labs and could soon become a standard imaging tool. For an application in broader fields of such algorithms, the availability of mitotic figure data sets of sufficient size for the respective tissue type and species is an important precondition, that is, however, rarely met. While algorithmic performance climbed steadily for e.g. human mammary carcinoma, thanks to several challenges held in the field, for most tumor types, data sets are not available. In this work, we assess domain transfer of mitotic figure recognition using domain adversarial training on four data sets, two from dogs and two from humans. We were able to show that domain adversarial training considerably improves accuracy when applying mitotic figure classification learned from the canine on the human data sets (up to +12.8% in accuracy) and is thus a helpful method to transfer knowledge from existing data sets to new tissue types and species.

AmirAbbas Davari, Nikolaos Sakaltras, Armin Haeberle et al.

Old master drawings were mostly created step by step in several layers using different materials. To art historians and restorers, examination of these layers brings various insights into the artistic work process and helps to answer questions about the object, its attribution and its authenticity. However, these layers typically overlap and are oftentimes difficult to differentiate with the unaided eye. For example, a common layer combination is red chalk under ink. In this work, we propose an image processing pipeline that operates on hyperspectral images to separate such layers. Using this pipeline, we show that hyperspectral images enable better layer separation than RGB images, and that spectral focus stacking aids the layer separation. In particular, we propose to use two descriptors in hyperspectral historical document analysis, namely hyper-hue and extended multi-attribute profile (EMAP). Our comparative results with other features underline the efficacy of the three proposed improvements.