Sergey V. Kovalchuk

Sergey V. Kovalchuk, Pavel A. Smirnov, Sergey S. Kosukhin et al.

This paper presents Virtual Simulation Objects (VSO) concept which forms theoretical basis for building tools and framework that is developed for system-level simulations using existing software modules available within cyber-infrastructure. Presented concept is implemented by the software tool for building composite solutions using VSO-based GUI and running them using CLAVIRE simulation environment.

Liubov O. Elkhovskaya, Alexander D. Kshenin, Marina A. Balakhontceva et al.

Within Process mining, discovery techniques had made it possible to construct business process models automatically from event logs. However, results often do not achieve the balance between model complexity and its fitting accuracy, so there is a need for manual model adjusting. The paper presents an approach to process mining providing semi-automatic support to model optimization based on the combined assessment of the model complexity and fitness. To balance between the two ingredients, a model simplification approach is proposed, which essentially abstracts the raw model at the desired granularity. Additionally, we introduce a concept of meta-states, a cycle collapsing in the model, which can potentially simplify the model and interpret it. We aim to demonstrate the capabilities of the technological solution using three datasets from different applications in the healthcare domain. They are remote monitoring process for patients with arterial hypertension and workflows of healthcare workers during the COVID-19 pandemic. A case study also investigates the use of various complexity measures and different ways of solution application providing insights on better practices in improving interpretability and complexity/fitness balance in process models.

Oleg V. Kubryak, Sergey V. Kovalchuk, Nadezhda G. Bagdasaryan

The article proposes a universal dual-axis intelligent systems assessment scale. The scale considers the properties of intelligent systems within the environmental context, which develops over time. In contrast to the frequent consideration of the 'mind' of artificial intelligent systems on a scale from 'weak' to 'strong', we highlight the modulating influences of anticipatory ability on their 'brute force'. In addition, the complexity, the 'weight' of the cognitive task and the ability to critically assess it beforehand determine the actual set of cognitive tools, the use of which provides the best result in these conditions. In fact, the presence of 'common sense' options is what connects the ability to solve a problem with the correct use of such an ability itself. The degree of 'correctness' and 'adequacy' is determined by the combination of a suitable solution with the temporal characteristics of the event, phenomenon, object or subject under study.

Tesfamariam M. Abuhay, Adane Mamuye, Stewart Robinson et al.

Patient flow analysis can be studied from a clinical and or operational perspective using simulation. Traditional statistical methods such as stochastic distribution methods have been used to construct patient flow simulation submodels such as patient inflow, Length of Stay (LoS), Cost of Treatment (CoT) and Clinical Pathway (CP) models. However, patient inflow demonstrates seasonality, trend and variation over time. LoS, CoT and CP are significantly determined by attributes of patients and clinical and laboratory test results. For this reason, patient flow simulation models constructed using traditional statistical methods are criticized for ignoring heterogeneity and their contribution to personalized and value based healthcare. On the other hand, machine learning methods have proven to be efficient to study and predict admission rate, LoS, CoT, and CP. This paper, hence, describes why coupling machine learning with patient flow simulation is important and proposes a conceptual architecture that shows how to integrate machine learning with patient flow simulation.

Sergey V. Kovalchuk, Georgy D. Kopanitsa, Ilia V. Derevitskii et al.

The paper presents an approach for building consistent and applicable clinical decision support systems (CDSSs) using a data-driven predictive model aimed at resolving the problem of low applicability and scalability of CDSSs in real-world applications. The approach is based on a threestage application of domain-specific and data-driven supportive procedures that are to be integrated into clinical business processes with higher trust and explainability of the prediction results and recommendations. Within the considered three stages, the regulatory policy, data-driven modes, and interpretation procedures are integrated to enable natural domain-specific interaction with decisionmakers with sequential narrowing of the intelligent decision support focus. The proposed methodology enables a higher level of automation, scalability, and semantic interpretability of CDSSs. The approach was implemented in software solutions and tested within a case study in T2DM prediction, enabling us to improve known clinical scales (such as FINDRISK) while keeping the problem-specific reasoning interface similar to existing applications. Such inheritance, together with the three-staged approach, provide higher compatibility of the solution and leads to trust, valid, and explainable application of data-driven solutions in real-world cases.

Anastasia A. Funkner, Aleksey N. Yakovlev, Sergey V. Kovalchuk

The paper proposes and investigates an approach for surrogate-assisted performance prediction of data-driven knowledge discovery algorithms. The approach is based on the identification of surrogate models for prediction of the target algorithm's quality and performance. The proposed approach was implemented and investigated as applied to an evolutionary algorithm for discovering clusters of interpretable clinical pathways in electronic health records of patients with acute coronary syndrome. Several clustering metrics and execution time were used as the target quality and performance metrics respectively. An analytical software prototype based on the proposed approach for the prediction of algorithm characteristics and feature analysis was developed to provide a more interpretable prediction of the target algorithm's performance and quality that can be further used for parameter tuning.

Tesfamariam M. Abuhay, Sergey V. Kovalchuk, Klavdiya O. Bochenina et al.

This paper presents results of topic modeling and network models of topics using the International Conference on Computational Science corpus, which contains domain-specific (computational science) papers over sixteen years (a total of 5695 papers). We discuss topical structures of International Conference on Computational Science, how these topics evolve over time in response to the topicality of various problems, technologies and methods, and how all these topics relate to one another. This analysis illustrates multidisciplinary research and collaborations among scientific communities, by constructing static and dynamic networks from the topic modeling results and the keywords of authors. The results of this study give insights about the past and future trends of core discussion topics in computational science. We used the Non-negative Matrix Factorization topic modeling algorithm to discover topics and labeled and grouped results hierarchically.

Pavel A. Smirnov, Sergey V. Kovalchuk, Alexander V. Boukhanovsky

The existing approaches for scientific workflows composition face the problems of domain knowledge integration. By this paper we summarize the results, which have been elaborated and implemented during the 2-year research concerning to Virtual Simulation Objects (VSO) concept and technology development. The contribution of this paper consists of formal models of the VSO internal structures and user-assistance logic, which may be obtained as a result of the reasoning over knowledge base. (This paper was rejected to appear in "Recent Advances in Knowledge Based Technologies and Applications" by Hindawi in 2014, but was stolen and published by Ke Han under the name "The Study on Workflows Composition Based on Virtual Simulation Objects Technology")

Sergey V. Kovalchuk, Pavel A. Smirnov, Konstantin V. Knyazkov et al.

Presented paper describes the development of comprehensive approach for knowledge processing within e-Sceince tasks. Considering the task solving within a simulation-driven approach a set of knowledge-based procedures for task definition and composite application processing can be identified. This procedures could be supported by the use of domain-specific knowledge being formalized and used for automation purpose. Within this work the developed conceptual and technological knowledge-based toolbox for complex multidisciplinary task solv-ing support is proposed. Using CLAVIRE cloud computing environment as a core platform a set of interconnected expressive technologies were developed.