Chi-Hieu Pham

Hussein Harb, Didier Benoit, Axel Rannou et al.

To develop a machine learning-based framework for accurately modeling the anode heel effect in Monte Carlo simulations of X-ray imaging systems, enabling realistic beam intensity profiles with minimal experimental calibration. Multiple regression models were trained to predict spatial intensity variations along the anode-cathode axis using experimentally acquired weights derived from beam measurements across different tube potentials. These weights captured the asymmetry introduced by the anode heel effect. A systematic fine-tuning protocol was established to minimize the number of required measurements while preserving model accuracy. The models were implemented in the OpenGATE 10 and GGEMS Monte Carlo toolkits to evaluate their integration feasibility and predictive performance. Among the tested models, gradient boosting regression (GBR) delivered the highest accuracy, with prediction errors remaining below 5% across all energy levels. The optimized fine-tuning strategy required only six detector positions per energy level, reducing measurement effort by 65%. The maximum error introduced through this fine-tuning process remained below 2%. Dose actor comparisons within Monte Carlo simulations demonstrated that the GBR-based model closely replicated clinical beam profiles and significantly outperformed conventional symmetric beam models. This study presents a robust and generalizable method for incorporating the anode heel effect into Monte Carlo simulations using machine learning. By enabling accurate, energy-dependent beam modeling with limited calibration data, the approach enhances simulation realism for applications in clinical dosimetry, image quality assessment, and radiation protection.

Chi-Hieu Pham, Saïd Ladjal, Alasdair Newson

Autoencoders and generative models produce some of the most spectacular deep learning results to date. However, understanding and controlling the latent space of these models presents a considerable challenge. Drawing inspiration from principal component analysis and autoencoder, we propose the Principal Component Analysis Autoencoder (PCAAE). This is a novel autoencoder whose latent space verifies two properties. Firstly, the dimensions are organised in decreasing importance with respect to the data at hand. Secondly, the components of the latent space are statistically independent. We achieve this by progressively increasing the latent space during training, and with a covariance loss applied to the latent codes. The resulting autoencoder produces a latent space which separates the intrinsic attributes of the data into different components of the latent space, in a completely unsupervised manner. We also describe an extension of our approach to the case of powerful, pre-trained GANs. We show results on both synthetic examples of shapes and on a state-of-the-art GAN. For example, we are able to separate the color shade scale of hair and skin, pose of faces and the gender in the CelebA, without accessing any labels. We compare the PCAAE with other state-of-the-art approaches, in particular with respect to the ability to disentangle attributes in the latent space. We hope that this approach will contribute to better understanding of the intrinsic latent spaces of powerful deep generative models.

Saïd Ladjal, Alasdair Newson, Chi-Hieu Pham

An autoencoder is a neural network which data projects to and from a lower dimensional latent space, where this data is easier to understand and model. The autoencoder consists of two sub-networks, the encoder and the decoder, which carry out these transformations. The neural network is trained such that the output is as close to the input as possible, the data having gone through an information bottleneck : the latent space. This tool bears significant ressemblance to Principal Component Analysis (PCA), with two main differences. Firstly, the autoencoder is a non-linear transformation, contrary to PCA, which makes the autoencoder more flexible and powerful. Secondly, the axes found by a PCA are orthogonal, and are ordered in terms of the amount of variability which the data presents along these axes. This makes the interpretability of the PCA much greater than that of the autoencoder, which does not have these attributes. Ideally, then, we would like an autoencoder whose latent space consists of independent components, ordered by decreasing importance to the data. In this paper, we propose an algorithm to create such a network. We create an iterative algorithm which progressively increases the size of the latent space, learning a new dimension at each step. Secondly, we propose a covariance loss term to add to the standard autoencoder loss function, as well as a normalisation layer just before the latent space, which encourages the latent space components to be statistically independent. We demonstrate the results of this autoencoder on simple geometric shapes, and find that the algorithm indeed finds a meaningful representation in the latent space. This means that subsequent interpolation in the latent space has meaning with respect to the geometric properties of the images.