Sebastian Frank

Nathalia Castellanos, Dhruv Desai, Sebastian Frank et al.

Peer analysis is a critical component of investment management, often relying on expert-provided categorization systems. These systems' consistency is questioned when they do not align with cohorts from unsupervised clustering algorithms optimized for various metrics. We investigate whether unsupervised clustering can reproduce ground truth classes in a labeled dataset, showing that success depends on feature selection and the chosen distance metric. Using toy datasets and fund categorization as real-world examples we demonstrate that accurately reproducing ground truth classes is challenging. We also highlight the limitations of standard clustering evaluation metrics in identifying the optimal number of clusters relative to the ground truth classes. We then show that if appropriate features are available in the dataset, and a proper distance metric is known (e.g., using a supervised Random Forest-based distance metric learning method), then an unsupervised clustering can indeed reproduce the ground truth classes as distinct clusters.

Simon Wein, Wilhelm Malloni, Ana Maria Tomé et al.

A central question in neuroscience is how self-organizing dynamic interactions in the brain emerge on their relatively static structural backbone. Due to the complexity of spatial and temporal dependencies between different brain areas, fully comprehending the interplay between structure and function is still challenging and an area of intense research. In this paper we present a graph neural network (GNN) framework, to describe functional interactions based on the structural anatomical layout. A GNN allows us to process graph-structured spatio-temporal signals, providing a possibility to combine structural information derived from diffusion tensor imaging (DTI) with temporal neural activity profiles, like observed in functional magnetic resonance imaging (fMRI). Moreover, dynamic interactions between different brain regions learned by this data-driven approach can provide a multi-modal measure of causal connectivity strength. We assess the proposed model's accuracy by evaluating its capabilities to replicate empirically observed neural activation profiles, and compare the performance to those of a vector auto regression (VAR), like typically used in Granger causality. We show that GNNs are able to capture long-term dependencies in data and also computationally scale up to the analysis of large-scale networks. Finally we confirm that features learned by a GNN can generalize across MRI scanner types and acquisition protocols, by demonstrating that the performance on small datasets can be improved by pre-training the GNN on data from an earlier and different study. We conclude that the proposed multi-modal GNN framework can provide a novel perspective on the structure-function relationship in the brain. Therewith this approach can be promising for the characterization of the information flow in brain networks.