Andreas Geert Motzfeldt

Valentin Liévin, Christoffer Egeberg Hother, Andreas Geert Motzfeldt et al.

Although large language models (LLMs) often produce impressive outputs, it remains unclear how they perform in real-world scenarios requiring strong reasoning skills and expert domain knowledge. We set out to investigate whether close- and open-source models (GPT-3.5, LLama-2, etc.) can be applied to answer and reason about difficult real-world-based questions. We focus on three popular medical benchmarks (MedQA-USMLE, MedMCQA, and PubMedQA) and multiple prompting scenarios: Chain-of-Thought (CoT, think step-by-step), few-shot and retrieval augmentation. Based on an expert annotation of the generated CoTs, we found that InstructGPT can often read, reason and recall expert knowledge. Last, by leveraging advances in prompt engineering (few-shot and ensemble methods), we demonstrated that GPT-3.5 not only yields calibrated predictive distributions, but also reaches the passing score on three datasets: MedQA-USMLE 60.2%, MedMCQA 62.7% and PubMedQA 78.2%. Open-source models are closing the gap: Llama-2 70B also passed the MedQA-USMLE with 62.5% accuracy.

Joakim Edin, Andreas Geert Motzfeldt, Casper L. Christensen et al.

Deep neural network predictions are notoriously difficult to interpret. Feature attribution methods aim to explain these predictions by identifying the contribution of each input feature. Faithfulness, often evaluated using the area over the perturbation curve (AOPC), reflects feature attributions' accuracy in describing the internal mechanisms of deep neural networks. However, many studies rely on AOPC to compare faithfulness across different models, which we show can lead to false conclusions about models' faithfulness. Specifically, we find that AOPC is sensitive to variations in the model, resulting in unreliable cross-model comparisons. Moreover, AOPC scores are difficult to interpret in isolation without knowing the model-specific lower and upper limits. To address these issues, we propose a normalization approach, Normalized AOPC (NAOPC), enabling consistent cross-model evaluations and more meaningful interpretation of individual scores. Our experiments demonstrate that this normalization can radically change AOPC results, questioning the conclusions of earlier studies and offering a more robust framework for assessing feature attribution faithfulness. Our code is available at https://github.com/JoakimEdin/naopc.

Valentin Liévin, Andreas Geert Motzfeldt, Ida Riis Jensen et al.

Retrieval-augmented models have proven to be effective in natural language processing tasks, yet there remains a lack of research on their optimization using variational inference. We introduce the Variational Open-Domain (VOD) framework for end-to-end training and evaluation of retrieval-augmented models, focusing on open-domain question answering and language modelling. The VOD objective, a self-normalized estimate of the Rényi variational bound, approximates the task marginal likelihood and is evaluated under samples drawn from an auxiliary sampling distribution (cached retriever and/or approximate posterior). It remains tractable, even for retriever distributions defined on large corpora. We demonstrate VOD's versatility by training reader-retriever BERT-sized models on multiple-choice medical exam questions. On the MedMCQA dataset, we outperform the domain-tuned Med-PaLM by +5.3% despite using 2.500$\times$ fewer parameters. Our retrieval-augmented BioLinkBERT model scored 62.9% on the MedMCQA and 55.0% on the MedQA-USMLE. Last, we show the effectiveness of our learned retriever component in the context of medical semantic search.