Nitin Kumar

VSS Tejaswi Abburi, Saurabh J. Shigwan, Nitin Kumar

In biomedical and neurodegenerative disorders, accurate and early disease identification remains challenging due to the scarcity of labeled data and the complexity of imaging patterns. To address these challenges, we introduce ARMA-C3, a unified unsupervised and semi-supervised graph learning framework for node classification based on contrastive learning and graph-cut regularization to learn structurally meaningful and discriminative representations. By modeling samples or images as graph nodes and exploiting inter-sample relationships, the proposed framework captures subject-level dependencies that conventional machine learning methods typically overlook. We conduct extensive binary classification experiments across five clinically relevant datasets: the Alzheimer's Disease Neuroimaging Initiative (ADNI), the Neuroimaging in Frontotemporal Dementia (NIFD) dataset, and three medical imaging benchmarks (BreastMNIST, PneumoniaMNIST, and a liver ultrasound dataset). Experimental results demonstrate that ARMA-C3 achieves competitive and frequently superior performance compared to classical clustering techniques, state-of-the-art machine learning models, and existing graph-based deep learning approaches across multiple evaluation settings, particularly under limited supervision and severe class imbalance. The proposed framework further demonstrates robust representation learning and strong cross-modal generalization across diverse biomedical imaging modalities.

A. Mudit Adityaja, Saurabh J. Shigwan, Nitin Kumar

The data-intensive nature of supervised classification drives the interest of the researchers towards unsupervised approaches, especially for problems such as medical image segmentation, where labeled data is scarce. Building on the recent advancements of Vision transformers (ViT) in computer vision, we propose an unsupervised segmentation framework using a pre-trained Dino-ViT. In the proposed method, we leverage the inherent graph structure within the image to realize a significant performance gain for segmentation in medical images. For this, we introduce a modularity-based loss function coupled with a Graph Attention Network (GAT) to effectively capture the inherent graph topology within the image. Our method achieves state-of-the-art performance, even significantly surpassing or matching that of existing (semi)supervised technique such as MedSAM which is a Segment Anything Model in medical images. We demonstrate this using two challenging medical image datasets ISIC-2018 and CVC-ColonDB. This work underscores the potential of unsupervised approaches in advancing medical image analysis in scenarios where labeled data is scarce. The github repository of the code is available on [https://github.com/mudit-adityaja/UnSegMedGAT].

Chanda Grover Kamra, Indra Deep Mastan, Nitin Kumar et al.

Recent developments in self-supervised learning (SSL) have made it possible to learn data representations without the need for annotations. Inspired by the non-contrastive SSL approach (SimSiam), we introduce a novel framework SIMSAM to compute the Semantic Affinity Matrix, which is significant for unsupervised image segmentation. Given an image, SIMSAM first extracts features using pre-trained DINO-ViT, then projects the features to predict the correlations of dense features in a non-contrastive way. We show applications of the Semantic Affinity Matrix in object segmentation and semantic segmentation tasks. Our code is available at https://github.com/chandagrover/SimSAM.

Kovvuri Sai Gopal Reddy, Bodduluri Saran, A. Mudit Adityaja et al.

Image segmentation, the process of partitioning an image into meaningful regions, plays a pivotal role in computer vision and medical imaging applications. Unsupervised segmentation, particularly in the absence of labeled data, remains a challenging task due to the inter-class similarity and variations in intensity and resolution. In this study, we extract high-level features of the input image using pretrained vision transformer. Subsequently, the proposed method leverages the underlying graph structures of the images, seeking to discover and delineate meaningful boundaries using graph neural networks and modularity based optimization criteria without relying on pre-labeled training data. Experimental results on benchmark datasets demonstrate the effectiveness and versatility of the proposed approach, showcasing competitive performance compared to the state-of-the-art unsupervised segmentation methods. This research contributes to the broader field of unsupervised medical imaging and computer vision by presenting an innovative methodology for image segmentation that aligns with real-world challenges. The proposed method holds promise for diverse applications, including medical imaging, remote sensing, and object recognition, where labeled data may be scarce or unavailable. The github repository of the code is available on [https://github.com/ksgr5566/unseggnet]

Arnav Aditya, Nitin Kumar, Saurabh Shigwan

Driven by advancements in deep learning, computer-aided diagnoses have made remarkable progress. However, outside controlled laboratory settings, algorithms may encounter several challenges. In the medical domain, these difficulties often stem from limited data availability due to ethical and legal restrictions, as well as the high cost and time required for expert annotations-especially in the face of emerging or rare diseases. In this context, open-set recognition plays a vital role by identifying whether a sample belongs to one of the known classes seen during training or should be rejected as an unknown. Recent studies have shown that features learned in the later stages of deep neural networks are observed to cluster around their class means, which themselves are arranged as individual vertices of a regular simplex [32]. The proposed method introduces a loss function designed to reject samples of unknown classes effectively by penalizing open space regions using auxiliary datasets. This approach achieves significant performance gain across four MedMNIST datasets-BloodMNIST, OCTMNIST, DermaMNIST, TissueMNIST and a publicly available skin dataset [29] outperforming state-of-the-art techniques.

Vishal, Arnav Aditya, Nitin Kumar et al.

Medical imaging datasets are often characterized by extreme class imbalances, where rare pathologies are significantly underrepresented compared to common conditions. This imbalance poses a dual challenge for Open-Set Recognition (OSR): models must maintain high classification accuracy on known classes while reliably rejecting unknown samples unseen during training in the clinical settings. While recently proposed Deep Simplex Classifier (DSC)~\cite{cevikalp2024reaching} and UnCertainty-aware Deep Simplex Classifier (UCDSC)~\cite{Aditya_2026_WACV} successfully leverage Neural Collapse to ensure maximal inter-class separation, they rely on a uniform margin that does not account for the varying densities of medical classes. In this paper, we propose DMDSC an enhanced framework featuring a dynamic margin approach. Our approach automatically adapts class-specific margins based on label frequency, enforcing a higher penalty and tighter feature clustering for rare pathologies to counteract the effects of data imbalance. Extensive experiments conducted on diverse medical benchmarks on BloodMNIST\cite{medmnistv2}, OCTMNIST\cite{medmnistv2}, DermaMNIST\cite{medmnistv2}, and BreaKHis~\cite{spanhol2015dataset} datasets, demonstrate that our framework outperforms state-of-the-art methods.

Aditya Hemant Shahane, Anuj Kumar Sirohi, Devansh Arora et al.

Bridging molecular structures and natural language is essential for controllable design. Autoregressive models struggle with long-range dependencies, while standard diffusion processes apply uniform corruption across positions, which can distort structurally informative tokens. We present BiMol-Diff, a unified diffusion framework for the paired tasks of text-conditioned molecule generation and molecule captioning. Our key component is a token-aware noise schedule that assigns position-dependent corruption based on token recovery difficulty, preserving harder-to-recover substructures during the forward process. On ChEBI-20 and M3-20M, BiMol-Diff improves molecule reconstruction with a 15.4% relative gain in Exact Match and achieves strong captioning results, attaining best BLEU and BERTScore among compared baselines. These results indicate token-aware noising improves fidelity in molecular structure-language modelling.

Nitin Kumar, Manisha

Cancelable Biometric is a challenging research field in which security of an original biometric image is ensured by transforming the original biometric into another irreversible domain. Several approaches have been suggested in literature for generating cancelable biometric templates. In this paper, two novel and simple cancelable biometric template generation methods based on Random Walk (CBRW) have been proposed. By employing random walk and other steps given in the proposed two algorithms viz. CBRW-BitXOR and CBRW-BitCMP, the original biometric is transformed into a cancellable template. The performance of the proposed methods is compared with other state-of-the-art methods. Experiments have been performed on eight publicly available gray and color datasets i.e. CP (ear) (gray and color), UTIRIS (iris) (gray and color), ORL (face) (gray), IIT Delhi (iris) (gray and color), and AR (face) (color). Performance of the generated templates is measured in terms of Correlation Coefficient (Cr), Root Mean Square Error (RMSE), Peak Signal to Noise Ratio (PSNR), Structural Similarity (SSIM), Mean Absolute Error (MAE), Number of Pixel Change Rate (NPCR), and Unified Average Changing Intensity (UACI). By experimental results, it has been proved that proposed methods are superior than other state-of-the-art methods in qualitative as well as quantitative analysis. Furthermore, CBRW performs better on both gray as well as color images.

Manisha, Nitin Kumar

Cancelable Biometric is repetitive distortion embedded in original Biometric image for keeping it secure from unauthorized access. In this paper, we have generated Cancelable Biometric templates with Reverse Boolean XOR technique. Three different methods have been proposed for generation of Cancelable Biometric templates based on Visual Secret Sharing scheme. In each method, one Secret image and n-1 Cover images are used as: (M1) One original Biometric image (Secret) with n- 1 randomly chosen Gray Cover images (M2) One original Secret image with n-1 Cover images, which are Randomly Permuted version of the original Secret image (M3) One Secret image with n-1 Cover images, both Secret image and Cover images are Randomly Permuted version of original Biometric image. Experiment works have performed on publicly available ORL Face database and IIT Delhi Iris database. The performance of the proposed methods is compared in terms of Co-relation Coefficient (Cr), Mean Square Error (MSE), Mean Absolute Error (MAE), Structural Similarity (SSIM), Peak Signal to Noise Ratio (PSNR), Number of Pixel Change Rate (NPCR), and Unified Average Changing Intensity (UACI). It is found that among the three proposed method, M3 generates good quality Cancelable templates and gives best performance in terms of quality. M3 is also better in quantitative terms on ORL dataset while M2 and M3 are comparable on IIT Delhi Iris dataset.

Devansh Arora, Nitin Kumar, Sukrit Gupta

Image segmentation is an important and widely performed task in computer vision. Accomplishing effective image segmentation in diverse settings often requires custom model architectures and loss functions. A set of models that specialize in segmenting thin tubular structures are topology preservation-based loss functions. These models often utilize a pixel skeletonization process claimed to generate more precise segmentation masks of thin tubes and better capture the structures that other models often miss. One such model, Skeleton Recall Loss (SRL) proposed by Kirchhoff et al.~\cite {kirchhoff2024srl}, was stated to produce state-of-the-art results on benchmark tubular datasets. In this work, we performed a theoretical analysis of the gradients for the SRL loss. Upon comparing the performance of the proposed method on some of the tubular datasets (used in the original work, along with some additional datasets), we found that the performance of SRL-based segmentation models did not exceed traditional baseline models. By providing both a theoretical explanation and empirical evidence, this work critically evaluates the limitations of topology-based loss functions, offering valuable insights for researchers aiming to develop more effective segmentation models for complex tubular structures.