Limin Yu

Syed Ashar Javed, Dinkar Juyal, Harshith Padigela et al.

Multiple Instance Learning (MIL) has been widely applied in pathology towards solving critical problems such as automating cancer diagnosis and grading, predicting patient prognosis, and therapy response. Deploying these models in a clinical setting requires careful inspection of these black boxes during development and deployment to identify failures and maintain physician trust. In this work, we propose a simple formulation of MIL models, which enables interpretability while maintaining similar predictive performance. Our Additive MIL models enable spatial credit assignment such that the contribution of each region in the image can be exactly computed and visualized. We show that our spatial credit assignment coincides with regions used by pathologists during diagnosis and improves upon classical attention heatmaps from attention MIL models. We show that any existing MIL model can be made additive with a simple change in function composition. We also show how these models can debug model failures, identify spurious features, and highlight class-wise regions of interest, enabling their use in high-stakes environments such as clinical decision-making.

Ylaine Gerardin, John Shamshoian, Judy Shen et al.

Nested pairwise frames is a method for relative benchmarking of cell or tissue digital pathology models against manual pathologist annotations on a set of sampled patches. At a high level, the method compares agreement between a candidate model and pathologist annotations with agreement among pathologists' annotations. This evaluation framework addresses fundamental issues of data size and annotator variability in using manual pathologist annotations as a source of ground truth for model validation. We implemented nested pairwise frames evaluation for tissue classification, cell classification, and cell count prediction tasks and show results for cell and tissue models deployed on an H&E-stained melanoma dataset.

Haocheng Zhao, Runwei Guan, Taoyu Wu et al.

4D millimeter-wave (MMW) radar, which provides both height information and dense point cloud data over 3D MMW radar, has become increasingly popular in 3D object detection. In recent years, radar-vision fusion models have demonstrated performance close to that of LiDAR-based models, offering advantages in terms of lower hardware costs and better resilience in extreme conditions. However, many radar-vision fusion models treat radar as a sparse LiDAR, underutilizing radar-specific information. Additionally, these multi-modal networks are often sensitive to the failure of a single modality, particularly vision. To address these challenges, we propose the Radar Depth Lift-Splat-Shoot (RDL) module, which integrates radar-specific data into the depth prediction process, enhancing the quality of visual Bird-Eye View (BEV) features. We further introduce a Unified Feature Fusion (UFF) approach that extracts BEV features across different modalities using shared module. To assess the robustness of multi-modal models, we develop a novel Failure Test (FT) ablation experiment, which simulates vision modality failure by injecting Gaussian noise. We conduct extensive experiments on the View-of-Delft (VoD) and TJ4D datasets. The results demonstrate that our proposed Unified BEVFusion (UniBEVFusion) network significantly outperforms state-of-the-art models on the TJ4D dataset, with improvements of 1.44 in 3D and 1.72 in BEV object detection accuracy.

Xiaoyang Wang, Huihui Bai, Limin Yu et al.

Semi-supervised semantic segmentation allows model to mine effective supervision from unlabeled data to complement label-guided training. Recent research has primarily focused on consistency regularization techniques, exploring perturbation-invariant training at both the image and feature levels. In this work, we proposed a novel feature-level consistency learning framework named Density-Descending Feature Perturbation (DDFP). Inspired by the low-density separation assumption in semi-supervised learning, our key insight is that feature density can shed a light on the most promising direction for the segmentation classifier to explore, which is the regions with lower density. We propose to shift features with confident predictions towards lower-density regions by perturbation injection. The perturbed features are then supervised by the predictions on the original features, thereby compelling the classifier to explore less dense regions to effectively regularize the decision boundary. Central to our method is the estimation of feature density. To this end, we introduce a lightweight density estimator based on normalizing flow, allowing for efficient capture of the feature density distribution in an online manner. By extracting gradients from the density estimator, we can determine the direction towards less dense regions for each feature. The proposed DDFP outperforms other designs on feature-level perturbations and shows state of the art performances on both Pascal VOC and Cityscapes dataset under various partition protocols. The project is available at https://github.com/Gavinwxy/DDFP.

Taoyu Wu, Yiyi Miao, Zhuoxiao Li et al.

Efficient three-dimensional reconstruction and real-time visualization are critical in surgical scenarios such as endoscopy. In recent years, 3D Gaussian Splatting (3DGS) has demonstrated remarkable performance in efficient 3D reconstruction and rendering. Most 3DGS-based Simultaneous Localization and Mapping (SLAM) methods only rely on the appearance constraints for optimizing both 3DGS and camera poses. However, in endoscopic scenarios, the challenges include photometric inconsistencies caused by non-Lambertian surfaces and dynamic motion from breathing affects the performance of SLAM systems. To address these issues, we additionally introduce optical flow loss as a geometric constraint, which effectively constrains both the 3D structure of the scene and the camera motion. Furthermore, we propose a depth regularisation strategy to mitigate the problem of photometric inconsistencies and ensure the validity of 3DGS depth rendering in endoscopic scenes. In addition, to improve scene representation in the SLAM system, we improve the 3DGS refinement strategy by focusing on viewpoints corresponding to Keyframes with suboptimal rendering quality frames, achieving better rendering results. Extensive experiments on the C3VD static dataset and the StereoMIS dynamic dataset demonstrate that our method outperforms existing state-of-the-art methods in novel view synthesis and pose estimation, exhibiting high performance in both static and dynamic surgical scenes.

Liye Jia, Runwei Guan, Haocheng Zhao et al.

3D object detection is crucial for Autonomous Driving (AD) and Advanced Driver Assistance Systems (ADAS). However, most 3D detectors prioritize detection accuracy, often overlooking network inference speed in practical applications. In this paper, we propose RadarNeXt, a real-time and reliable 3D object detector based on the 4D mmWave radar point clouds. It leverages the re-parameterizable neural networks to catch multi-scale features, reduce memory cost and accelerate the inference. Moreover, to highlight the irregular foreground features of radar point clouds and suppress background clutter, we propose a Multi-path Deformable Foreground Enhancement Network (MDFEN), ensuring detection accuracy while minimizing the sacrifice of speed and excessive number of parameters. Experimental results on View-of-Delft and TJ4DRadSet datasets validate the exceptional performance and efficiency of RadarNeXt, achieving 50.48 and 32.30 mAPs with the variant using our proposed MDFEN. Notably, our RadarNeXt variants achieve inference speeds of over 67.10 FPS on the RTX A4000 GPU and 28.40 FPS on the Jetson AGX Orin. This research demonstrates that RadarNeXt brings a novel and effective paradigm for 3D perception based on 4D mmWave radar.

Qing Chang, Wei Dai, Zhihao Shuai et al.

Naturalistic driving action recognition is essential for vehicle cabin monitoring systems. However, the complexity of real-world backgrounds presents significant challenges for this task, and previous approaches have struggled with practical implementation due to their limited ability to observe subtle behavioral differences and effectively learn inter-frame features from video. In this paper, we propose a novel Spatial-Temporal Perception (STP) architecture that emphasizes both temporal information and spatial relationships between key objects, incorporating a causal decoder to perform behavior recognition and temporal action localization. Without requiring multimodal input, STP directly extracts temporal and spatial distance features from RGB video clips. Subsequently, these dual features are jointly encoded by maximizing the expected likelihood across all possible permutations of the factorization order. By integrating temporal and spatial features at different scales, STP can perceive subtle behavioral changes in challenging scenarios. Additionally, we introduce a causal-aware module to explore relationships between video frame features, significantly enhancing detection efficiency and performance. We validate the effectiveness of our approach using two publicly available driver distraction detection benchmarks. The results demonstrate that our framework achieves state-of-the-art performance.

Zixun Lan, Binjie Hong, Jiajun Zhu et al.

Predicting reactants from a specified core product stands as a fundamental challenge within organic synthesis, termed retrosynthesis prediction. Recently, semi-template-based methods and graph-edits-based methods have achieved good performance in terms of both interpretability and accuracy. However, due to their mechanisms these methods cannot predict complex reactions, e.g., reactions with multiple reaction center or attaching the same leaving group to more than one atom. In this study we propose a semi-template-based method, the \textbf{Retro}synthesis via \textbf{S}earch \textbf{i}n (Hyper) \textbf{G}raph (RetroSiG) framework to alleviate these limitations. In the proposed method, we turn the reaction center identification and the leaving group completion tasks as tasks of searching in the product molecular graph and leaving group hypergraph respectively. As a semi-template-based method RetroSiG has several advantages. First, RetroSiG is able to handle the complex reactions mentioned above by its novel search mechanism. Second, RetroSiG naturally exploits the hypergraph to model the implicit dependencies between leaving groups. Third, RetroSiG makes full use of the prior, i.e., one-hop constraint. It reduces the search space and enhances overall performance. Comprehensive experiments demonstrated that RetroSiG achieved competitive results. Furthermore, we conducted experiments to show the capability of RetroSiG in predicting complex reactions. Ablation experiments verified the efficacy of specific elements, such as the one-hop constraint and the leaving group hypergraph.

Zixun Lan, Limin Yu, Linglong Yuan et al.

As one of the most fundamental tasks in graph theory, subgraph matching is a crucial task in many fields, ranging from information retrieval, computer vision, biology, chemistry and natural language processing. Yet subgraph matching problem remains to be an NP-complete problem. This study proposes an end-to-end learning-based approximate method for subgraph matching task, called subgraph matching network (Sub-GMN). The proposed Sub-GMN firstly uses graph representation learning to map nodes to node-level embedding. It then combines metric learning and attention mechanisms to model the relationship between matched nodes in the data graph and query graph. To test the performance of the proposed method, we applied our method on two databases. We used two existing methods, GNN and FGNN as baseline for comparison. Our experiment shows that, on dataset 1, on average the accuracy of Sub-GMN are 12.21\% and 3.2\% higher than that of GNN and FGNN respectively. On average running time Sub-GMN runs 20-40 times faster than FGNN. In addition, the average F1-score of Sub-GMN on all experiments with dataset 2 reached 0.95, which demonstrates that Sub-GMN outputs more correct node-to-node matches. Comparing with the previous GNNs-based methods for subgraph matching task, our proposed Sub-GMN allows varying query and data graphes in the test/application stage, while most previous GNNs-based methods can only find a matched subgraph in the data graph during the test/application for the same query graph used in the training stage. Another advantage of our proposed Sub-GMN is that it can output a list of node-to-node matches, while most existing end-to-end GNNs based methods cannot provide the matched node pairs.

Junli Cao, B. S., Junyan Wu et al.

Background: Margin assessment of basal cell carcinoma using the frozen section is a common task of pathology intraoperative consultation. Although frequently straight-forward, the determination of the presence or absence of basal cell carcinoma on the tissue sections can sometimes be challenging. We explore if a deep learning model trained on mobile phone-acquired frozen section images can have adequate performance for future deployment. Materials and Methods: One thousand two hundred and forty-one (1241) images of frozen sections performed for basal cell carcinoma margin status were acquired using mobile phones. The photos were taken at 100x magnification (10x objective). The images were downscaled from a 4032 x 3024 pixel resolution to 576 x 432 pixel resolution. Semantic segmentation algorithm Deeplab V3 with Xception backbone was used for model training. Results: The model uses an image as input and produces a 2-dimensional black and white output of prediction of the same dimension; the areas determined to be basal cell carcinoma were displayed with white color, in a black background. Any output with the number of white pixels exceeding 0.5% of the total number of pixels is deemed positive for basal cell carcinoma. On the test set, the model achieves area under curve of 0.99 for receiver operator curve and 0.97 for precision-recall curve at the pixel level. The accuracy of classification at the slide level is 96%. Conclusions: The deep learning model trained with mobile phone images shows satisfactory performance characteristics, and thus demonstrates the potential for deploying as a mobile phone app to assist in frozen section interpretation in real time.

Yujie Wang, Simon Sun, Jahow Yu et al.

As melanoma diagnoses increase across the US, automated efforts to identify malignant lesions become increasingly of interest to the research community. Segmentation of dermoscopic images is the first step in this process, thus accuracy is crucial. Although techniques utilizing convolutional neural networks have been used in the past for lesion segmentation, we present a solution employing the recently published DeepLab 3, an atrous convolution method for image segmentation. Although the results produced by this run are not ideal, with a mean Jaccard index of 0.498, we believe that with further adjustments and modifications to the compatibility with the DeepLab code and with training on more powerful processing units, this method may achieve better results in future trials.