Zhongyuan Zhang

Zhongyuan Zhang, Yi Qian, Yanxiang Zhao et al.

Unlike ordinary computer vision tasks that focus more on the semantic content of images, the image manipulation detection task pays more attention to the subtle information of image manipulation. In this paper, the noise image extracted by the improved constrained convolution is used as the input of the model instead of the original image to obtain more subtle traces of manipulation. Meanwhile, the dual-branch network, consisting of a high-resolution branch and a context branch, is used to capture the traces of artifacts as much as possible. In general, most manipulation leaves manipulation artifacts on the manipulation edge. A specially designed manipulation edge detection module is constructed based on the dual-branch network to identify these artifacts better. The correlation between pixels in an image is closely related to their distance. The farther the two pixels are, the weaker the correlation. We add a distance factor to the self-attention module to better describe the correlation between pixels. Experimental results on four publicly available image manipulation datasets demonstrate the effectiveness of our model.

Qing Qing, Xikun Zhang, Zhongyuan Zhang et al.

Aging clocks aim to estimate biological age, a measure of physiological state distinct from chronological age, from observable biomarkers, and are widely used for health assessment and disease analysis. DNA methylation is a particularly informative biomarker due to its stability and strong association with aging, and recent learning-based approaches have improved predictive performance. However, most existing methods treat CpG sites as independent features, overlooking the complex and heterogeneous biological relationships among them. We propose RelAge-GNN, a multi-relational graph neural network framework for DNA methylation-based age prediction. Our method constructs three complementary graphs capturing co-methylation patterns, genomic co-localization, and gene-level associations among CpG sites. Each graph is modeled by an independent GNN branch, and a learnable gating mechanism adaptively fuses the resulting representations. Experiments on large-scale datasets show that RelAge-GNN achieves competitive accuracy and stronger correlation with chronological age compared to state-of-the-art methods. Moreover, the model exhibits improved sensitivity in detecting age acceleration across diverse disease cohorts, highlighting its potential utility for disease characterization. Finally, through post hoc interpretability analyses, we quantify the contributions of different relational structures and CpG sites, providing biologically meaningful insights and suggesting potential directions for aging-related research. Our code is available at: https://anonymous.4open.science/r/RelAge-GNN-F1E3/.

Yangmei Chen, Zhongyuan Zhang, Xikun Zhang et al.

Thyroid nodule classification using ultrasound imaging is essential for early diagnosis and clinical decision-making; however, despite promising performance on in-distribution data, existing deep learning methods often exhibit limited robustness and generalisation when deployed across different ultrasound devices or clinical environments. This limitation is mainly attributed to the pronounced heterogeneity of thyroid ultrasound images, which can lead models to capture spurious correlations rather than reliable diagnostic cues. To address this challenge, we propose PEMV-thyroid, a Prototype-Enhanced Multi-View learning framework that accounts for data heterogeneity by learning complementary representations from multiple feature perspectives and refining decision boundaries through a prototype-based correction mechanism with mixed prototype information. By integrating multi-view representations with prototype-level guidance, the proposed approach enables more stable representation learning under heterogeneous imaging conditions. Extensive experiments on multiple thyroid ultrasound datasets demonstrate that PEMV-thyroid consistently outperforms state-of-the-art methods, particularly in cross-device and cross-domain evaluation scenarios, leading to improved diagnostic accuracy and generalisation performance in real-world clinical settings. The source code is available at https://github.com/chenyangmeii/Prototype-Enhanced-Multi-View-Learning.

Yifei Zhao, Fanyu Zhao, Zhongyuan Zhang et al.

Generalized few-shot 3D point cloud segmentation aims to adapt to novel classes from only a few annotations while maintaining strong performance on base classes, but this remains challenging due to the inherent stability-plasticity trade-off: adapting to novel classes can interfere with shared representations and cause base-class forgetting. We present HOP3D, a unified framework that learns hierarchical orthogonal prototypes with an entropy-based few-shot regularizer to enable robust novel-class adaptation without degrading base-class performance. HOP3D introduces hierarchical orthogonalization that decouples base and novel learning at both the gradient and representation levels, effectively mitigating base-novel interference. To further enhance adaptation under sparse supervision, we incorporate an entropy-based regularizer that leverages predictive uncertainty to refine prototype learning and promote balanced predictions. Extensive experiments on ScanNet200 and ScanNet++ demonstrate that HOP3D consistently outperforms state-of-the-art baselines under both 1-shot and 5-shot settings. The code is available at https://fdueblab-hop3d.github.io/.