Devrim Unay

Kenan Morani, Esra Kaya Ayana, Devrim Unay

The significance of efficient and accurate diagnosis amidst the unique challenges posed by the COVID-19 pandemic underscores the urgency for innovative approaches. In response to these challenges, we propose a transfer learning-based approach using a recently annotated Computed Tomography (CT) image database. While many approaches propose an intensive data preproseccing and/or complex model architecture, our method focusses on offering an efficient solution with minimal manual engineering. Specifically, we investigate the suitability of a modified Xception model for COVID-19 detection. The method involves adapting a pre-trained Xception model, incorporating both the architecture and pre-trained weights from ImageNet. The output of the model was designed to take the final diagnosis decisions. The training utilized 128 batch sizes and 224x224 input image dimensions, downsized from standard 512x512. No further da processing was performed on the input data. Evaluation is conducted on the 'COV19-CT-DB' CT image dataset, containing labeled COVID-19 and non-COVID-19 cases. Results reveal the method's superiority in accuracy, precision, recall, and macro F1 score on the validation subset, outperforming VGG-16 transfer model and thus offering enhanced precision with fewer parameters. Furthermore, when compared to alternative methods for the COV19-CT-DB dataset, our approach exceeds the baseline approach and other alternatives on the same dataset. Finally, the adaptability of the modified Xception trasnfer learning-based model to the unique features of the COV19-CT-DB dataset showcases its potential as a robust tool for enhanced COVID-19 diagnosis from CT images.

Kenan Morani, Devrim Unay

A method of a Convolutional Neural Networks (CNN) for image classification with image preprocessing and hyperparameters tuning was proposed. The method aims at increasing the predictive performance for COVID-19 diagnosis while more complex model architecture. Firstly, the CNN model includes four similar convolutional layers followed by a flattening and two dense layers. This work proposes a less complex solution based on simply classifying 2D-slices of Computed Tomography scans. Despite the simplicity in architecture, the proposed CNN model showed improved quantitative results exceeding state-of-the-art when predicting slice cases. The results were achieved on the annotated CT slices of the COV-19-CT-DB dataset. Secondly, the original dataset was processed via anatomy-relevant masking of slice, removing none-representative slices from the CT volume, and hyperparameters tuning. For slice processing, a fixed-sized rectangular area was used for cropping an anatomy-relevant region-of-interest in the images, and a threshold based on the number of white pixels in binarized slices was employed to remove none-representative slices from the 3D-CT scans. The CNN model with a learning rate schedule and an exponential decay and slice flipping techniques was deployed on the processed slices. The proposed method was used to make predictions on the 2D slices and for final diagnosis at patient level, majority voting was applied on the slices of each CT scan to take the diagnosis. The macro F1 score of the proposed method well-exceeded the baseline approach and other alternatives on the validation set as well as on a test partition of previously unseen images from COV-19CT-DB dataset.

Refik Soyak, Ebru Navruz, Eda Ozgu Ersoy et al.

Magnetic Resonance Fingerprinting (MRF) enables simultaneous mapping of multiple tissue parameters such as T1 and T2 relaxation times. The working principle of MRF relies on varying acquisition parameters pseudo-randomly, so that each tissue generates its unique signal evolution during scanning. Even though MRF provides faster scanning, it has disadvantages such as erroneous and slow generation of the corresponding parametric maps, which needs to be improved. Moreover, there is a need for explainable architectures for understanding the guiding signals to generate accurate parametric maps. In this paper, we addressed both of these shortcomings by proposing a novel neural network architecture consisting of a channel-wise attention module and a fully convolutional network. The proposed approach, evaluated over 3 simulated MRF signals, reduces error in the reconstruction of tissue parameters by 8.88% for T1 and 75.44% for T2 with respect to state-of-the-art methods. Another contribution of this study is a new channel selection method: attention-based channel selection. Furthermore, the effect of patch size and temporal frames of MRF signal on channel reduction are analyzed by employing a channel-wise attention.

Ertunc Erdil, Ali Ozgur Argunsah, Tolga Tasdizen et al.

Data driven segmentation is an important initial step of shape prior-based segmentation methods since it is assumed that the data term brings a curve to a plausible level so that shape and data terms can then work together to produce better segmentations. When purely data driven segmentation produces poor results, the final segmentation is generally affected adversely. One challenge faced by many existing data terms is due to the fact that they consider only pixel intensities to decide whether to assign a pixel to the foreground or to the background region. When the distributions of the foreground and background pixel intensities have significant overlap, such data terms become ineffective, as they produce uncertain results for many pixels in a test image. In such cases, using prior information about the spatial context of the object to be segmented together with the data term can bring a curve to a plausible stage, which would then serve as a good initial point to launch shape-based segmentation. In this paper, we propose a new segmentation approach that combines nonparametric context priors with a learned-intensity-based data term and nonparametric shape priors. We perform experiments for dendritic spine segmentation in both 2D and 3D 2-photon microscopy images. The experimental results demonstrate that using spatial context priors leads to significant improvements.

Muhammad Usman Ghani, Ertunc Erdil, Sumeyra Demir Kanik et al.

Functional properties of neurons are strongly coupled with their morphology. Changes in neuronal activity alter morphological characteristics of dendritic spines. First step towards understanding the structure-function relationship is to group spines into main spine classes reported in the literature. Shape analysis of dendritic spines can help neuroscientists understand the underlying relationships. Due to unavailability of reliable automated tools, this analysis is currently performed manually which is a time-intensive and subjective task. Several studies on spine shape classification have been reported in the literature, however, there is an on-going debate on whether distinct spine shape classes exist or whether spines should be modeled through a continuum of shape variations. Another challenge is the subjectivity and bias that is introduced due to the supervised nature of classification approaches. In this paper, we aim to address these issues by presenting a clustering perspective. In this context, clustering may serve both confirmation of known patterns and discovery of new ones. We perform cluster analysis on two-photon microscopic images of spines using morphological, shape, and appearance based features and gain insights into the spine shape analysis problem. We use histogram of oriented gradients (HOG), disjunctive normal shape models (DNSM), morphological features, and intensity profile based features for cluster analysis. We use x-means to perform cluster analysis that selects the number of clusters automatically using the Bayesian information criterion (BIC). For all features, this analysis produces 4 clusters and we observe the formation of at least one cluster consisting of spines which are difficult to be assigned to a known class. This observation supports the argument of intermediate shape types.