Gil Tabak

Mitchelle Rasquinha, Gil Tabak

As deep learning methodologies have developed, it has been generally agreed that increasing neural network size improves model quality. However, this is at the expense of memory and compute requirements, which also need to be increased. Various efficiency techniques have been proposed to rein in hardware costs, one being the use of low precision numerics. Recent accelerators have introduced several different 8-bit data types to help accommodate DNNs in terms of numerics. In this paper, we identify a metric driven methodology to aid in the choice of numerics. We demonstrate how such a methodology can help scale training of a language representation model. The technique can be generalized to other model architectures.

Gil Tabak, Minjie Fan, Samuel J. Yang et al.

Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drug compounds applied at different doses can be quantified. The general approach is to find a function mapping the images to an embedding space of manageable dimensionality whose geometry captures relevant features of the input images. An important known issue for such methods is separating relevant biological signal from nuisance variation. For example, the embedding vectors tend to be more correlated for cells that were cultured and imaged during the same week than for those from different weeks, despite having identical drug compounds applied in both cases. In this case, the particular batch in which a set of experiments were conducted constitutes the domain of the data; an ideal set of image embeddings should contain only the relevant biological information (e.g. drug effects). We develop a general framework for adjusting the image embeddings in order to `forget' domain-specific information while preserving relevant biological information. To achieve this, we minimize a loss function based on distances between marginal distributions (such as the Wasserstein distance) of embeddings across domains for each replicated treatment. For the dataset we present results with, the only replicated treatment happens to be the negative control treatment, for which we do not expect any treatment-induced cell morphology changes. We find that for our transformed embeddings (i) the underlying geometric structure is not only preserved but the embeddings also carry improved biological signal; and (ii) less domain-specific information is present.