Chengwei Pan

Chengwei Pan, Gangming Zhao, Junjie Fang et al.

Although deep learning algorithms have been intensively developed for computer-aided tuberculosis diagnosis (CTD), they mainly depend on carefully annotated datasets, leading to much time and resource consumption. Weakly supervised learning (WSL), which leverages coarse-grained labels to accomplish fine-grained tasks, has the potential to solve this problem. In this paper, we first propose a new large-scale tuberculosis (TB) chest X-ray dataset, namely the tuberculosis chest X-ray attribute dataset (TBX-Att), and then establish an attribute-assisted weakly-supervised framework to classify and localize TB by leveraging the attribute information to overcome the insufficiency of supervision in WSL scenarios. Specifically, first, the TBX-Att dataset contains 2000 X-ray images with seven kinds of attributes for TB relational reasoning, which are annotated by experienced radiologists. It also includes the public TBX11K dataset with 11200 X-ray images to facilitate weakly supervised detection. Second, we exploit a multi-scale feature interaction model for TB area classification and detection with attribute relational reasoning. The proposed model is evaluated on the TBX-Att dataset and will serve as a solid baseline for future research. The code and data will be available at https://github.com/GangmingZhao/tb-attribute-weak-localization.

Gangming Zhao, Kongming Liang, Chengwei Pan et al.

Vessel segmentation is widely used to help with vascular disease diagnosis. Vessels reconstructed using existing methods are often not sufficiently accurate to meet clinical use standards. This is because 3D vessel structures are highly complicated and exhibit unique characteristics, including sparsity and anisotropy. In this paper, we propose a novel hybrid deep neural network for vessel segmentation. Our network consists of two cascaded subnetworks performing initial and refined segmentation respectively. The second subnetwork further has two tightly coupled components, a traditional CNN-based U-Net and a graph U-Net. Cross-network multi-scale feature fusion is performed between these two U-shaped networks to effectively support high-quality vessel segmentation. The entire cascaded network can be trained from end to end. The graph in the second subnetwork is constructed according to a vessel probability map as well as appearance and semantic similarities in the original CT volume. To tackle the challenges caused by the sparsity and anisotropy of vessels, a higher percentage of graph nodes are distributed in areas that potentially contain vessels while a higher percentage of edges follow the orientation of potential nearbyvessels. Extensive experiments demonstrate our deep network achieves state-of-the-art 3D vessel segmentation performance on multiple public and in-house datasets.

Yinghao Zhu, Zixiang Wang, Long He et al.

Electronic Health Records (EHRs) contain a wealth of patient data; however, the sparsity of EHRs data often presents significant challenges for predictive modeling. Conventional imputation methods inadequately distinguish between real and imputed data, leading to potential inaccuracies of patient representations. To address these issues, we introduce PRISM, a framework that indirectly imputes data by leveraging prototype representations of similar patients, thus ensuring compact representations that preserve patient information. PRISM also includes a feature confidence learner module, which evaluates the reliability of each feature considering missing statuses. Additionally, PRISM introduces a new patient similarity metric that accounts for feature confidence, avoiding over-reliance on imprecise imputed values. Our extensive experiments on the MIMIC-III, MIMIC-IV, PhysioNet Challenge 2012, eICU datasets demonstrate PRISM's superior performance in predicting in-hospital mortality and 30-day readmission tasks, showcasing its effectiveness in handling EHR data sparsity. For the sake of reproducibility and further research, we have publicly released the code at https://github.com/yhzhu99/PRISM.

Yinghao Zhu, Junyi Gao, Zixiang Wang et al.

Large Language Models (LLMs) are increasingly deployed in medicine. However, their utility in non-generative clinical prediction, often presumed inferior to specialized models, remains under-evaluated, leading to ongoing debate within the field and potential for misuse, misunderstanding, or over-reliance due to a lack of systematic benchmarking. Our ClinicRealm study addresses this by benchmarking 15 GPT-style LLMs, 5 BERT-style models, and 11 traditional methods on unstructured clinical notes and structured Electronic Health Records (EHR), while also assessing their reasoning, reliability, and fairness. Key findings reveal a significant shift: for clinical note predictions, leading LLMs (e.g., DeepSeek-V3.1-Think, GPT-5) in zero-shot settings now decisively outperform finetuned BERT models. On structured EHRs, while specialized models excel with ample data, advanced LLMs (e.g., GPT-5, DeepSeek-V3.1-Think) show potent zero-shot capabilities, often surpassing conventional models in data-scarce settings. Notably, leading open-source LLMs can match or exceed proprietary counterparts. These results provide compelling evidence that modern LLMs are competitive tools for non-generative clinical prediction, particularly with unstructured text and offering data-efficient structured data options, thus necessitating a re-evaluation of model selection strategies. This research should serve as an important insight for medical informaticists, AI developers, and clinical researchers, potentially prompting a reassessment of current assumptions and inspiring new approaches to LLM application in predictive healthcare.

Yinghao Zhu, Jingkun An, Enshen Zhou et al. · tencent-ai

In the data-driven artificial intelligence paradigm, models heavily rely on large amounts of training data. However, factors like sampling distribution imbalance can lead to issues of bias and unfairness in healthcare data. Sensitive attributes, such as race, gender, age, and medical condition, are characteristics of individuals that are commonly associated with discrimination or bias. In healthcare AI, these attributes can play a significant role in determining the quality of care that individuals receive. For example, minority groups often receive fewer procedures and poorer-quality medical care than white individuals in US. Therefore, detecting and mitigating bias in data is crucial to enhancing health equity. Bias mitigation methods include pre-processing, in-processing, and post-processing. Among them, Reweighting (RW) is a widely used pre-processing method that performs well in balancing machine learning performance and fairness performance. RW adjusts the weights for samples within each (group, label) combination, where these weights are utilized in loss functions. However, RW is limited to considering only a single sensitive attribute when mitigating bias and assumes that each sensitive attribute is equally important. This may result in potential inaccuracies when addressing intersectional bias. To address these limitations, we propose M3Fair, a multi-level and multi-sensitive-attribute reweighting method by extending the RW method to multiple sensitive attributes at multiple levels. Our experiments on real-world datasets show that the approach is effective, straightforward, and generalizable in addressing the healthcare fairness issues.

Mai Su, Qihan Yu, Zhongtao Wang et al.

3D Gaussian Splatting enables efficient optimization and high-quality rendering, yet accurate surface reconstruction remains challenging. Prior methods improve surface reconstruction by refining Gaussian depth estimates, either via multi-view geometric consistency or through monocular depth priors. However, multi-view constraints become unreliable under large geometric discrepancies, while monocular priors suffer from scale ambiguity and local inconsistency, ultimately leading to inaccurate Gaussian depth supervision. To address these limitations, we introduce a Gaussian visibility-aware multi-view geometric consistency constraint that aggregates the visibility of shared Gaussian primitives across views, enabling more accurate and stable geometric supervision. In addition, we propose a progressive quadtree-calibrated Monocular depth constraint that performs block-wise affine calibration from coarse to fine spatial scales, mitigating the scale ambiguity of depth priors while preserving fine-grained surface details. Extensive experiments on DTU and TNT datasets demonstrate consistent improvements in geometric accuracy over prior Gaussian-based and implicit surface reconstruction methods. Codes are available at an anonymous repository: https://github.com/GVGScode/GVGS.

Renmiao Chen, Yida Lu, Shiyao Cui et al.

As Multimodal Large Language Models (MLLMs) acquire stronger reasoning capabilities to handle complex, multi-image instructions, this advancement may pose new safety risks. We study this problem by introducing MIR-SafetyBench, the first benchmark focused on multi-image reasoning safety, which consists of 2,676 instances across a taxonomy of 9 multi-image relations. Our extensive evaluations on 19 MLLMs reveal a troubling trend: models with more advanced multi-image reasoning can be more vulnerable on MIR-SafetyBench. Beyond attack success rates, we find that many responses labeled as safe are superficial, often driven by misunderstanding or evasive, non-committal replies. We further observe that unsafe generations exhibit lower attention entropy than safe ones on average. This internal signature suggests a possible risk that models may over-focus on task solving while neglecting safety constraints. Our code and data are available at https://github.com/thu-coai/MIR-SafetyBench.

Weibin Liao, Yinghao Zhu, Xinyuan Wang et al.

UNet and its variants have been widely used in medical image segmentation. However, these models, especially those based on Transformer architectures, pose challenges due to their large number of parameters and computational loads, making them unsuitable for mobile health applications. Recently, State Space Models (SSMs), exemplified by Mamba, have emerged as competitive alternatives to CNN and Transformer architectures. Building upon this, we employ Mamba as a lightweight substitute for CNN and Transformer within UNet, aiming at tackling challenges stemming from computational resource limitations in real medical settings. To this end, we introduce the Lightweight Mamba UNet (LightM-UNet) that integrates Mamba and UNet in a lightweight framework. Specifically, LightM-UNet leverages the Residual Vision Mamba Layer in a pure Mamba fashion to extract deep semantic features and model long-range spatial dependencies, with linear computational complexity. Extensive experiments conducted on two real-world 2D/3D datasets demonstrate that LightM-UNet surpasses existing state-of-the-art literature. Notably, when compared to the renowned nnU-Net, LightM-UNet achieves superior segmentation performance while drastically reducing parameter and computation costs by 116x and 21x, respectively. This highlights the potential of Mamba in facilitating model lightweighting. Our code implementation is publicly available at https://github.com/MrBlankness/LightM-UNet.

Zhiru Wang, Shiyun Xie, Chengwei Pan et al.

Recently, the 3D Gaussian Splatting (3D-GS) method has achieved great success in novel view synthesis, providing real-time rendering while ensuring high-quality rendering results. However, this method faces challenges in modeling specular reflections and handling anisotropic appearance components, especially in dealing with view-dependent color under complex lighting conditions. Additionally, 3D-GS uses spherical harmonic to learn the color representation, which has limited ability to represent complex scenes. To overcome these challenges, we introduce Lantent-SpecGS, an approach that utilizes a universal latent neural descriptor within each 3D Gaussian. This enables a more effective representation of 3D feature fields, including appearance and geometry. Moreover, two parallel CNNs are designed to decoder the splatting feature maps into diffuse color and specular color separately. A mask that depends on the viewpoint is learned to merge these two colors, resulting in the final rendered image. Experimental results demonstrate that our method obtains competitive performance in novel view synthesis and extends the ability of 3D-GS to handle intricate scenarios with specular reflections.

Zhexin Zhang, Leqi Lei, Junxiao Yang et al.

As AI models are increasingly deployed across diverse real-world scenarios, ensuring their safety remains a critical yet underexplored challenge. While substantial efforts have been made to evaluate and enhance AI safety, the lack of a standardized framework and comprehensive toolkit poses significant obstacles to systematic research and practical adoption. To bridge this gap, we introduce AISafetyLab, a unified framework and toolkit that integrates representative attack, defense, and evaluation methodologies for AI safety. AISafetyLab features an intuitive interface that enables developers to seamlessly apply various techniques while maintaining a well-structured and extensible codebase for future advancements. Additionally, we conduct empirical studies on Vicuna, analyzing different attack and defense strategies to provide valuable insights into their comparative effectiveness. To facilitate ongoing research and development in AI safety, AISafetyLab is publicly available at https://github.com/thu-coai/AISafetyLab, and we are committed to its continuous maintenance and improvement.

Jingkun An, Yinghao Zhu, Zongjian Li et al.

Text-to-Image (T2I) diffusion models have achieved remarkable success in image generation. Despite their progress, challenges remain in both prompt-following ability, image quality and lack of high-quality datasets, which are essential for refining these models. As acquiring labeled data is costly, we introduce AGFSync, a framework that enhances T2I diffusion models through Direct Preference Optimization (DPO) in a fully AI-driven approach. AGFSync utilizes Vision-Language Models (VLM) to assess image quality across style, coherence, and aesthetics, generating feedback data within an AI-driven loop. By applying AGFSync to leading T2I models such as SD v1.4, v1.5, and SDXL-base, our extensive experiments on the TIFA dataset demonstrate notable improvements in VQA scores, aesthetic evaluations, and performance on the HPSv2 benchmark, consistently outperforming the base models. AGFSync's method of refining T2I diffusion models paves the way for scalable alignment techniques. Our code and dataset are publicly available at https://anjingkun.github.io/AGFSync.

Renmiao Chen, Shiyao Cui, Xuancheng Huang et al.

Jailbreak attacks against multimodal large language Models (MLLMs) are a significant research focus. Current research predominantly focuses on maximizing attack success rate (ASR), often overlooking whether the generated responses actually fulfill the attacker's malicious intent. This oversight frequently leads to low-quality outputs that bypass safety filters but lack substantial harmful content. To address this gap, we propose JPS, \underline{J}ailbreak MLLMs with collaborative visual \underline{P}erturbation and textual \underline{S}teering, which achieves jailbreaks via corporation of visual image and textually steering prompt. Specifically, JPS utilizes target-guided adversarial image perturbations for effective safety bypass, complemented by "steering prompt" optimized via a multi-agent system to specifically guide LLM responses fulfilling the attackers' intent. These visual and textual components undergo iterative co-optimization for enhanced performance. To evaluate the quality of attack outcomes, we propose the Malicious Intent Fulfillment Rate (MIFR) metric, assessed using a Reasoning-LLM-based evaluator. Our experiments show JPS sets a new state-of-the-art in both ASR and MIFR across various MLLMs and benchmarks, with analyses confirming its efficacy. Codes are available at \href{https://github.com/thu-coai/JPS}{https://github.com/thu-coai/JPS}. \color{warningcolor}{Warning: This paper contains potentially sensitive contents.}

Zhongtao Wang, Jiaqi Dai, Qingtian Zhu et al.

Multi-period image collections are common in real-world applications. Cities are re-scanned for mapping, construction sites are revisited for progress tracking, and natural regions are monitored for environmental change. Such data form multi-period scenes, where geometry and appearance evolve. Reconstructing such scenes is an important yet underexplored problem. Existing pipelines rely on incompatible assumptions: static and in-the-wild methods enforce a single geometry, while dynamic ones assume smooth motion, both failing under long-term, discontinuous changes. To solve this problem, we introduce ChronoGS, a temporally modulated Gaussian representation that reconstructs all periods within a unified anchor scaffold. It's also designed to disentangle stable and evolving components, achieving temporally consistent reconstruction of multi-period scenes. To catalyze relevant research, we release ChronoScene dataset, a benchmark of real and synthetic multi-period scenes, capturing geometric and appearance variation. Experiments demonstrate that ChronoGS consistently outperforms baselines in reconstruction quality and temporal consistency. Our code and the ChronoScene dataset are publicly available at https://github.com/ZhongtaoWang/ChronoGS.

Yinghao Zhu, Zixiang Wang, Junyi Gao et al.

The inherent complexity of structured longitudinal Electronic Health Records (EHR) data poses a significant challenge when integrated with Large Language Models (LLMs), which are traditionally tailored for natural language processing. Motivated by the urgent need for swift decision-making during new disease outbreaks, where traditional predictive models often fail due to a lack of historical data, this research investigates the adaptability of LLMs, like GPT-4, to EHR data. We particularly focus on their zero-shot capabilities, which enable them to make predictions in scenarios in which they haven't been explicitly trained. In response to the longitudinal, sparse, and knowledge-infused nature of EHR data, our prompting approach involves taking into account specific EHR characteristics such as units and reference ranges, and employing an in-context learning strategy that aligns with clinical contexts. Our comprehensive experiments on the MIMIC-IV and TJH datasets demonstrate that with our elaborately designed prompting framework, LLMs can improve prediction performance in key tasks such as mortality, length-of-stay, and 30-day readmission by about 35\%, surpassing ML models in few-shot settings. Our research underscores the potential of LLMs in enhancing clinical decision-making, especially in urgent healthcare situations like the outbreak of emerging diseases with no labeled data. The code is publicly available at https://github.com/yhzhu99/llm4healthcare for reproducibility.

Baolian Qi, Gangming Zhao, Xin Wei et al.

Locating diseases in chest X-ray images with few careful annotations saves large human effort. Recent works approached this task with innovative weakly-supervised algorithms such as multi-instance learning (MIL) and class activation maps (CAM), however, these methods often yield inaccurate or incomplete regions. One of the reasons is the neglection of the pathological implications hidden in the relationship across anatomical regions within each image and the relationship across images. In this paper, we argue that the cross-region and cross-image relationship, as contextual and compensating information, is vital to obtain more consistent and integral regions. To model the relationship, we propose the Graph Regularized Embedding Network (GREN), which leverages the intra-image and inter-image information to locate diseases on chest X-ray images. GREN uses a pre-trained U-Net to segment the lung lobes, and then models the intra-image relationship between the lung lobes using an intra-image graph to compare different regions. Meanwhile, the relationship between in-batch images is modeled by an inter-image graph to compare multiple images. This process mimics the training and decision-making process of a radiologist: comparing multiple regions and images for diagnosis. In order for the deep embedding layers of the neural network to retain structural information (important in the localization task), we use the Hash coding and Hamming distance to compute the graphs, which are used as regularizers to facilitate training. By means of this, our approach achieves the state-of-the-art result on NIH chest X-ray dataset for weakly-supervised disease localization. Our codes are accessible online (https://github.com/qibaolian/GREN).

Yinghao Zhu, Changyu Ren, Shiyun Xie et al.

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context relevent to clinical tasks, prompting the incorporation of external knowledge, particularly from the knowledge graph (KG). Previous approaches with KG knowledge have primarily focused on structured knowledge extraction, neglecting unstructured data modalities and semantic high dimensional medical knowledge. In response, we propose REALM, a Retrieval-Augmented Generation (RAG) driven framework to enhance multimodal EHR representations that address these limitations. Firstly, we apply Large Language Model (LLM) to encode long context clinical notes and GRU model to encode time-series EHR data. Secondly, we prompt LLM to extract task-relevant medical entities and match entities in professionally labeled external knowledge graph (PrimeKG) with corresponding medical knowledge. By matching and aligning with clinical standards, our framework eliminates hallucinations and ensures consistency. Lastly, we propose an adaptive multimodal fusion network to integrate extracted knowledge with multimodal EHR data. Our extensive experiments on MIMIC-III mortality and readmission tasks showcase the superior performance of our REALM framework over baselines, emphasizing the effectiveness of each module. REALM framework contributes to refining the use of multimodal EHR data in healthcare and bridging the gap with nuanced medical context essential for informed clinical predictions.

Xu Wang, Zhiru Wang, Shiyun Xie et al.

While 3D Gaussian Splatting (3DGS) achieves real-time photorealistic rendering, its performance degrades significantly when training images contain transient objects that violate multi-view consistency. Existing methods face a circular dependency: accurate transient detection requires a well-reconstructed static scene, while clean reconstruction itself depends on reliable transient masks. We address this challenge with DualSplat, a Failure-to-Prior framework that converts first-pass reconstruction failures into explicit priors for a second reconstruction stage. We observe that transients, which appear in only a subset of views, often manifest as incomplete fragments during conservative initial training. We exploit these failures to construct object-level pseudo-masks by combining photometric residuals, feature mismatches, and SAM2 instance boundaries. These pseudo-masks then guide a clean second-pass 3DGS optimization, while a lightweight MLP refines them online by gradually shifting from prior supervision to self-consistency. Experiments on RobustNeRF and NeRF On-the-go show that DualSplat outperforms existing baselines, demonstrating particularly clear advantages in transient-heavy scenes and transient regions.

Hao Wang, Hao Li, Junda Zhu et al.

Large Language Models (LLMs) are susceptible to generating harmful content when prompted with carefully crafted inputs, a vulnerability known as LLM jailbreaking. As LLMs become more powerful, studying jailbreak methods is critical to enhancing security and aligning models with human values. Traditionally, jailbreak techniques have relied on suffix addition or prompt templates, but these methods suffer from limited attack diversity. This paper introduces DiffusionAttacker, an end-to-end generative approach for jailbreak rewriting inspired by diffusion models. Our method employs a sequence-to-sequence (seq2seq) text diffusion model as a generator, conditioning on the original prompt and guiding the denoising process with a novel attack loss. Unlike previous approaches that use autoregressive LLMs to generate jailbreak prompts, which limit the modification of already generated tokens and restrict the rewriting space, DiffusionAttacker utilizes a seq2seq diffusion model, allowing more flexible token modifications. This approach preserves the semantic content of the original prompt while producing harmful content. Additionally, we leverage the Gumbel-Softmax technique to make the sampling process from the diffusion model's output distribution differentiable, eliminating the need for iterative token search. Extensive experiments on Advbench and Harmbench demonstrate that DiffusionAttacker outperforms previous methods across various evaluation metrics, including attack success rate (ASR), fluency, and diversity.

Xinyuan Wang, Victor Shea-Jay Huang, Renmiao Chen et al.

While large language models (LLMs) exhibit remarkable capabilities across various tasks, they encounter potential security risks such as jailbreak attacks, which exploit vulnerabilities to bypass security measures and generate harmful outputs. Existing jailbreak strategies mainly focus on maximizing attack success rate (ASR), frequently neglecting other critical factors, including the relevance of the jailbreak response to the query and the level of stealthiness. This narrow focus on single objectives can result in ineffective attacks that either lack contextual relevance or are easily recognizable. In this work, we introduce BlackDAN, an innovative black-box attack framework with multi-objective optimization, aiming to generate high-quality prompts that effectively facilitate jailbreaking while maintaining contextual relevance and minimizing detectability. BlackDAN leverages Multiobjective Evolutionary Algorithms (MOEAs), specifically the NSGA-II algorithm, to optimize jailbreaks across multiple objectives including ASR, stealthiness, and semantic relevance. By integrating mechanisms like mutation, crossover, and Pareto-dominance, BlackDAN provides a transparent and interpretable process for generating jailbreaks. Furthermore, the framework allows customization based on user preferences, enabling the selection of prompts that balance harmfulness, relevance, and other factors. Experimental results demonstrate that BlackDAN outperforms traditional single-objective methods, yielding higher success rates and improved robustness across various LLMs and multimodal LLMs, while ensuring jailbreak responses are both relevant and less detectable.

Shiyun Xie, Zhiru Wang, Yinghao Zhu et al.

Recently, 3D Gaussian Splatting (3DGS) has excelled in novel view synthesis (NVS) with its real-time rendering capabilities and superior quality. However, it encounters challenges for high-resolution novel view synthesis (HRNVS) due to the coarse nature of primitives derived from low-resolution input views. To address this issue, we propose SuperGS, an expansion of Scaffold-GS designed with a two-stage coarse-to-fine training framework. In the low-resolution stage, we introduce a latent feature field to represent the low-resolution scene, which serves as both the initialization and foundational information for super-resolution optimization. In the high-resolution stage, we propose a multi-view consistent densification strategy that backprojects high-resolution depth maps based on error maps and employs a multi-view voting mechanism, mitigating ambiguities caused by multi-view inconsistencies in the pseudo labels provided by 2D prior models while avoiding Gaussian redundancy. Furthermore, we model uncertainty through variational feature learning and use it to guide further scene representation refinement and adjust the supervisory effect of pseudo-labels, ensuring consistent and detailed scene reconstruction. Extensive experiments demonstrate that SuperGS outperforms state-of-the-art HRNVS methods on both forward-facing and 360-degree datasets.

Mai Su, Zhongtao Wang, Huishan Au et al.

3DGS is an emerging and increasingly popular technology in the field of novel view synthesis. Its highly realistic rendering quality and real-time rendering capabilities make it promising for various applications. However, when applied to large-scale aerial urban scenes, 3DGS methods suffer from issues such as excessive memory consumption, slow training times, prolonged partitioning processes, and significant degradation in rendering quality due to the increased data volume. To tackle these challenges, we introduce \textbf{HUG}, a novel approach that enhances data partitioning and reconstruction quality by leveraging a hierarchical neural Gaussian representation. We first propose a visibility-based data partitioning method that is simple yet highly efficient, significantly outperforming existing methods in speed. Then, we introduce a novel hierarchical weighted training approach, combined with other optimization strategies, to substantially improve reconstruction quality. Our method achieves state-of-the-art results on one synthetic dataset and four real-world datasets.

Runpu Wei, Zijin Yin, Kongming Liang et al.

Automatic polyp segmentation is helpful to assist clinical diagnosis and treatment. In daily clinical practice, clinicians exhibit robustness in identifying polyps with both location and size variations. It is uncertain if deep segmentation models can achieve comparable robustness in automated colonoscopic analysis. To benchmark the model robustness, we focus on evaluating the robustness of segmentation models on the polyps with various attributes (e.g. location and size) and healthy samples. Based on the Latent Diffusion Model, we perform attribute editing on real polyps and build a new dataset named Polyp-E. Our synthetic dataset boasts exceptional realism, to the extent that clinical experts find it challenging to discern them from real data. We evaluate several existing polyp segmentation models on the proposed benchmark. The results reveal most of the models are highly sensitive to attribute variations. As a novel data augmentation technique, the proposed editing pipeline can improve both in-distribution and out-of-distribution generalization ability. The code and datasets will be released.

Gangming Zhao, Chaoqi Chen, Wenhao He et al.

Conventional domain adaptation typically transfers knowledge from a source domain to a stationary target domain. However, in many real-world cases, target data usually emerge sequentially and have continuously evolving distributions. Restoring and adapting to such target data results in escalating computational and resource consumption over time. Hence, it is vital to devise algorithms to address the evolving domain adaptation (EDA) problem, \emph{i.e.,} adapting models to evolving target domains without access to historic target domains. To achieve this goal, we propose a simple yet effective approach, termed progressive conservative adaptation (PCAda). To manage new target data that diverges from previous distributions, we fine-tune the classifier head based on the progressively updated class prototypes. Moreover, as adjusting to the most recent target domain can interfere with the features learned from previous target domains, we develop a conservative sparse attention mechanism. This mechanism restricts feature adaptation within essential dimensions, thus easing the inference related to historical knowledge. The proposed PCAda is implemented with a meta-learning framework, which achieves the fast adaptation of the classifier with the help of the progressively updated class prototypes in the inner loop and learns a generalized feature without severely interfering with the historic knowledge via the conservative sparse attention in the outer loop. Experiments on Rotated MNIST, Caltran, and Portraits datasets demonstrate the effectiveness of our method.

Xinyuan Wang, Chengwei Pan, Hongming Dai et al.

Coronary microvascular disease constitutes a substantial risk to human health. Employing computer-aided analysis and diagnostic systems, medical professionals can intervene early in disease progression, with 3D vessel segmentation serving as a crucial component. Nevertheless, conventional U-Net architectures tend to yield incoherent and imprecise segmentation outcomes, particularly for small vessel structures. While models with attention mechanisms, such as Transformers and large convolutional kernels, demonstrate superior performance, their extensive computational demands during training and inference lead to increased time complexity. In this study, we leverage Fourier domain learning as a substitute for multi-scale convolutional kernels in 3D hierarchical segmentation models, which can reduce computational expenses while preserving global receptive fields within the network. Furthermore, a zero-parameter frequency domain fusion method is designed to improve the skip connections in U-Net architecture. Experimental results on a public dataset and an in-house dataset indicate that our novel Fourier transformation-based network achieves remarkable dice performance (84.37\% on ASACA500 and 80.32\% on ImageCAS) in tubular vessel segmentation tasks and substantially reduces computational requirements without compromising global receptive fields.

Jiafa He, Chengwei Pan, Can Yang et al.

Automatic blood vessel extraction from 3D medical images is crucial for vascular disease diagnoses. Existing methods based on convolutional neural networks (CNNs) may suffer from discontinuities of extracted vessels when segmenting such thin tubular structures from 3D images. We argue that preserving the continuity of extracted vessels requires to take into account the global geometry. However, 3D convolutions are computationally inefficient, which prohibits the 3D CNNs from sufficiently large receptive fields to capture the global cues in the entire image. In this work, we propose a hybrid representation learning approach to address this challenge. The main idea is to use CNNs to learn local appearances of vessels in image crops while using another point-cloud network to learn the global geometry of vessels in the entire image. In inference, the proposed approach extracts local segments of vessels using CNNs, classifies each segment based on global geometry using the point-cloud network, and finally connects all the segments that belong to the same vessel using the shortest-path algorithm. This combination results in an efficient, fully-automatic and template-free approach to centerline extraction from 3D images. We validate the proposed approach on CTA datasets and demonstrate its superior performance compared to both traditional and CNN-based baselines.

Yicheng Wu, Chengwei Pan, Shuqi Wang et al.

Analyzing the morphological attributes of blood vessels plays a critical role in the computer-aided diagnosis of many cardiovascular and ophthalmologic diseases. Although being extensively studied, segmentation of blood vessels, particularly thin vessels and capillaries, remains challenging mainly due to the lack of an effective interaction between local and global features. In this paper, we propose a novel deep learning model called PC-Net to segment retinal vessels and major arteries in 2D fundus image and 3D computed tomography angiography (CTA) scans, respectively. In PC-Net, the pyramid squeeze-and-excitation (PSE) module introduces spatial information to each convolutional block, boosting its ability to extract more effective multi-scale features, and the coarse-to-fine (CF) module replaces the conventional decoder to enhance the details of thin vessels and process hard-to-classify pixels again. We evaluated our PC-Net on the Digital Retinal Images for Vessel Extraction (DRIVE) database and an in-house 3D major artery (3MA) database against several recent methods. Our results not only demonstrate the effectiveness of the proposed PSE module and CF module, but also suggest that our proposed PC-Net sets new state of the art in the segmentation of retinal vessels (AUC: 98.31%) and major arteries (AUC: 98.35%) on both databases, respectively.

Shen Wang, Kongming Liang, Chengwei Pan et al.

The midline related pathological image features are crucial for evaluating the severity of brain compression caused by stroke or traumatic brain injury (TBI). The automated midline delineation not only improves the assessment and clinical decision making for patients with stroke symptoms or head trauma but also reduces the time of diagnosis. Nevertheless, most of the previous methods model the midline by localizing the anatomical points, which are hard to detect or even missing in severe cases. In this paper, we formulate the brain midline delineation as a segmentation task and propose a three-stage framework. The proposed framework firstly aligns an input CT image into the standard space. Then, the aligned image is processed by a midline detection network (MD-Net) integrated with the CoordConv Layer and Cascade AtrousCconv Module to obtain the probability map. Finally, we formulate the optimal midline selection as a pathfinding problem to solve the problem of the discontinuity of midline delineation. Experimental results show that our proposed framework can achieve superior performance on one in-house dataset and one public dataset.

Chaowei Fang, Guanbin Li, Chengwei Pan et al.

Recently 3D volumetric organ segmentation attracts much research interest in medical image analysis due to its significance in computer aided diagnosis. This paper aims to address the pancreas segmentation task in 3D computed tomography volumes. We propose a novel end-to-end network, Globally Guided Progressive Fusion Network, as an effective and efficient solution to volumetric segmentation, which involves both global features and complicated 3D geometric information. A progressive fusion network is devised to extract 3D information from a moderate number of neighboring slices and predict a probability map for the segmentation of each slice. An independent branch for excavating global features from downsampled slices is further integrated into the network. Extensive experimental results demonstrate that our method achieves state-of-the-art performance on two pancreas datasets.

Wei Li, Chengwei Pan, Rong Zhang et al.

Simulation systems have become an essential component in the development and validation of autonomous driving technologies. The prevailing state-of-the-art approach for simulation is to use game engines or high-fidelity computer graphics (CG) models to create driving scenarios. However, creating CG models and vehicle movements (e.g., the assets for simulation) remains a manual task that can be costly and time-consuming. In addition, the fidelity of CG images still lacks the richness and authenticity of real-world images and using these images for training leads to degraded performance. In this paper we present a novel approach to address these issues: Augmented Autonomous Driving Simulation (AADS). Our formulation augments real-world pictures with a simulated traffic flow to create photo-realistic simulation images and renderings. More specifically, we use LiDAR and cameras to scan street scenes. From the acquired trajectory data, we generate highly plausible traffic flows for cars and pedestrians and compose them into the background. The composite images can be re-synthesized with different viewpoints and sensor models. The resulting images are photo-realistic, fully annotated, and ready for end-to-end training and testing of autonomous driving systems from perception to planning. We explain our system design and validate our algorithms with a number of autonomous driving tasks from detection to segmentation and predictions. Compared to traditional approaches, our method offers unmatched scalability and realism. Scalability is particularly important for AD simulation and we believe the complexity and diversity of the real world cannot be realistically captured in a virtual environment. Our augmented approach combines the flexibility in a virtual environment (e.g., vehicle movements) with the richness of the real world to allow effective simulation of anywhere on earth.