Yinda Chen

Yinda Chen, Wei Huang, Shenglong Zhou et al.

The performance of existing supervised neuron segmentation methods is highly dependent on the number of accurate annotations, especially when applied to large scale electron microscopy (EM) data. By extracting semantic information from unlabeled data, self-supervised methods can improve the performance of downstream tasks, among which the mask image model (MIM) has been widely used due to its simplicity and effectiveness in recovering original information from masked images. However, due to the high degree of structural locality in EM images, as well as the existence of considerable noise, many voxels contain little discriminative information, making MIM pretraining inefficient on the neuron segmentation task. To overcome this challenge, we propose a decision-based MIM that utilizes reinforcement learning (RL) to automatically search for optimal image masking ratio and masking strategy. Due to the vast exploration space, using single-agent RL for voxel prediction is impractical. Therefore, we treat each input patch as an agent with a shared behavior policy, allowing for multi-agent collaboration. Furthermore, this multi-agent model can capture dependencies between voxels, which is beneficial for the downstream segmentation task. Experiments conducted on representative EM datasets demonstrate that our approach has a significant advantage over alternative self-supervised methods on the task of neuron segmentation. Code is available at \url{https://github.com/ydchen0806/dbMiM}.

Yinda Chen, Che Liu, Wei Huang et al.

Vision-Language Pretraining (VLP) has demonstrated remarkable capabilities in learning visual representations from textual descriptions of images without annotations. Yet, effective VLP demands large-scale image-text pairs, a resource that suffers scarcity in the medical domain. Moreover, conventional VLP is limited to 2D images while medical images encompass diverse modalities, often in 3D, making the learning process more challenging. To address these challenges, we present Generative Text-Guided 3D Vision-Language Pretraining for Unified Medical Image Segmentation (GTGM), a framework that extends of VLP to 3D medical images without relying on paired textual descriptions. Specifically, GTGM utilizes large language models (LLM) to generate medical-style text from 3D medical images. This synthetic text is then used to supervise 3D visual representation learning. Furthermore, a negative-free contrastive learning objective strategy is introduced to cultivate consistent visual representations between augmented 3D medical image patches, which effectively mitigates the biases associated with strict positive-negative sample pairings. We evaluate GTGM on three imaging modalities - Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and electron microscopy (EM) over 13 datasets. GTGM's superior performance across various medical image segmentation tasks underscores its effectiveness and versatility, by enabling VLP extension into 3D medical imagery while bypassing the need for paired text.

Yinda Chen, Wei Huang, Xiaoyu Liu et al.

Instance segmentation in electron microscopy (EM) volumes is tough due to complex shapes and sparse annotations. Self-supervised learning helps but still struggles with intricate visual patterns in EM. To address this, we propose a pretraining framework that enhances multiscale consistency in EM volumes. Our approach leverages a Siamese network architecture, integrating both strong and weak data augmentations to effectively extract multiscale features. We uphold voxel-level coherence by reconstructing the original input data from these augmented instances. Furthermore, we incorporate cross-attention mechanisms to facilitate fine-grained feature alignment between these augmentations. Finally, we apply contrastive learning techniques across a feature pyramid, allowing us to distill distinctive representations spanning various scales. After pretraining on four large-scale EM datasets, our framework significantly improves downstream tasks like neuron and mitochondria segmentation, especially with limited finetuning data. It effectively captures voxel and feature consistency, showing promise for learning transferable representations for EM analysis.

Yinda Chen, Che Liu, Xiaoyu Liu et al.

The burgeoning integration of 3D medical imaging into healthcare has led to a substantial increase in the workload of medical professionals. To assist clinicians in their diagnostic processes and alleviate their workload, the development of a robust system for retrieving similar case studies presents a viable solution. While the concept holds great promise, the field of 3D medical text-image retrieval is currently limited by the absence of robust evaluation benchmarks and curated datasets. To remedy this, our study presents a groundbreaking dataset, {BIMCV-R}, which includes an extensive collection of 8,069 3D CT volumes, encompassing over 2 million slices, paired with their respective radiological reports. Expanding upon the foundational work of our dataset, we craft a retrieval strategy, MedFinder. This approach employs a dual-stream network architecture, harnessing the potential of large language models to advance the field of medical image retrieval beyond existing text-image retrieval solutions. It marks our preliminary step towards developing a system capable of facilitating text-to-image, image-to-text, and keyword-based retrieval tasks. Our project is available at \url{https://huggingface.co/datasets/cyd0806/BIMCV-R}.

Zheyuan Zhou, Liang Du, Zixun Sun et al.

Despite significant progress in Visual-Language-Action (VLA), in highly complex and dynamic environments that involve real-time unpredictable interactions (such as 3D open worlds and large-scale PvP games), existing approaches remain inefficient at extracting action-critical signals from redundant sensor streams. To tackle this, we introduce MAIN-VLA, a framework that explicitly Models the Abstraction of Intention and eNvironment to ground decision-making in deep semantic alignment rather than superficial pattern matching. Specifically, our Intention Abstraction (IA) extracts verbose linguistic instructions and their associated reasoning into compact, explicit semantic primitives, while the Environment Semantics Abstraction (ESA) projects overwhelming visual streams into a structured, topological affordance representation. Furthermore, aligning these two abstract modalities induces an emergent attention-concentration effect, enabling a parameter-free token-pruning strategy that filters out perceptual redundancy without degrading performance. Extensive experiments in open-world Minecraft and large-scale PvP environments (Game for Peace and Valorant) demonstrate that MAIN-VLA sets a new state-of-the-art, which achieves superior decision quality, stronger generalization, and cutting-edge inference efficiency.

Dapeng Zhang, Dayu Chen, Peng Zhi et al.

Constructing online High-Definition (HD) maps is crucial for the static environment perception of autonomous driving systems (ADS). Existing solutions typically attempt to detect vectorized HD map elements with unified models; however, these methods often overlook the distinct characteristics of different non-cubic map elements, making accurate distinction challenging. To address these issues, we introduce an expert-based online HD map method, termed MapExpert. MapExpert utilizes sparse experts, distributed by our routers, to describe various non-cubic map elements accurately. Additionally, we propose an auxiliary balance loss function to distribute the load evenly across experts. Furthermore, we theoretically analyze the limitations of prevalent bird's-eye view (BEV) feature temporal fusion methods and introduce an efficient temporal fusion module called Learnable Weighted Moving Descentage. This module effectively integrates relevant historical information into the final BEV features. Combined with an enhanced slice head branch, the proposed MapExpert achieves state-of-the-art performance and maintains good efficiency on both nuScenes and Argoverse2 datasets.

Che Liu, Zhongwei Wan, Haozhe Wang et al.

Medical Vision-Language Pre-training (MedVLP) has made significant progress in enabling zero-shot tasks for medical image understanding. However, training MedVLP models typically requires large-scale datasets with paired, high-quality image-text data, which are scarce in the medical domain. Recent advancements in Large Language Models (LLMs) and diffusion models have made it possible to generate large-scale synthetic image-text pairs. This raises the question: "Can MedVLP succeed using purely synthetic data?" To address this, we use off-the-shelf generative models to create synthetic radiology reports and paired Chest X-ray (CXR) images, and propose an automated pipeline to build a diverse, high-quality synthetic dataset, enabling a rigorous study that isolates model and training settings, focusing entirely from the data perspective. Our results show that MedVLP models trained exclusively on synthetic data outperform those trained on real data by 3.8% in averaged AUC on zero-shot classification. Moreover, using a combination of synthetic and real data leads to a further improvement of 9.07%. Additionally, MedVLP models trained on synthetic or mixed data consistently outperform those trained on real data in zero-shot grounding, as well as in fine-tuned classification and segmentation tasks. Our analysis suggests MedVLP trained on well-designed synthetic data can outperform models trained on real datasets, which may be limited by low-quality samples and long-tailed distributions.

Che Liu, Yinda Chen, Haoyuan Shi et al.

The advent of large-scale vision foundation models, pre-trained on diverse natural images, has marked a paradigm shift in computer vision. However, how the frontier vision foundation models' efficacies transfer to specialized domains remains such as medical imaging remains an open question. This report investigates whether DINOv3, a state-of-the-art self-supervised vision transformer (ViT) that features strong capability in dense prediction tasks, can directly serve as a powerful, unified encoder for medical vision tasks without domain-specific pre-training. To answer this, we benchmark DINOv3 across common medical vision tasks, including 2D/3D classification and segmentation on a wide range of medical imaging modalities. We systematically analyze its scalability by varying model sizes and input image resolutions. Our findings reveal that DINOv3 shows impressive performance and establishes a formidable new baseline. Remarkably, it can even outperform medical-specific foundation models like BiomedCLIP and CT-Net on several tasks, despite being trained solely on natural images. However, we identify clear limitations: The model's features degrade in scenarios requiring deep domain specialization, such as in Whole-Slide Pathological Images (WSIs), Electron Microscopy (EM), and Positron Emission Tomography (PET). Furthermore, we observe that DINOv3 does not consistently obey scaling law in the medical domain; performance does not reliably increase with larger models or finer feature resolutions, showing diverse scaling behaviors across tasks. Ultimately, our work establishes DINOv3 as a strong baseline, whose powerful visual features can serve as a robust prior for multiple complex medical tasks. This opens promising future directions, such as leveraging its features to enforce multiview consistency in 3D reconstruction.

Yinglong Li, Xiaoyu Liu, Jiacheng Li et al.

State Space Models (SSMs), as key components of Mamaba, have gained increasing attention for vision models recently, thanks to their efficient long sequence modeling capability. Given the computational cost of deploying SSMs on resource-limited edge devices, Post-Training Quantization (PTQ) is a technique with the potential for efficient deployment of SSMs. In this work, we propose QMamba, one of the first PTQ frameworks to our knowledge, designed for vision SSMs based on the analysis of the activation distributions in SSMs. We reveal that the distribution of discrete parameters exhibits long-tailed skewness and the distribution of the hidden state sequence exhibits highly dynamic variations. Correspondingly, we design Long-tailed Skewness Quantization (LtSQ) to quantize discrete parameters and Temporal Group Quantization (TGQ) to quantize hidden states, which reduces the quantization errors. Extensive experiments demonstrate that QMamba outperforms advanced PTQ methods on vision models across multiple model sizes and architectures. Notably, QMamba surpasses existing methods by 21.0% on ImageNet classification with 4-bit activations.

Jiawen Wang, Yinda Chen, Xiaoyu Liu et al.

Recent works have correlated Masked Image Modeling (MIM) with consistency regularization in Unsupervised Domain Adaptation (UDA). However, they merely treat masking as a special form of deformation on the input images and neglect the theoretical analysis, which leads to a superficial understanding of masked reconstruction and insufficient exploitation of its potential in enhancing feature extraction and representation learning. In this paper, we reframe masked reconstruction as a sparse signal reconstruction problem and theoretically prove that the dual form of complementary masks possesses superior capabilities in extracting domain-agnostic image features. Based on this compelling insight, we propose MaskTwins, a simple yet effective UDA framework that integrates masked reconstruction directly into the main training pipeline. MaskTwins uncovers intrinsic structural patterns that persist across disparate domains by enforcing consistency between predictions of images masked in complementary ways, enabling domain generalization in an end-to-end manner. Extensive experiments verify the superiority of MaskTwins over baseline methods in natural and biological image segmentation. These results demonstrate the significant advantages of MaskTwins in extracting domain-invariant features without the need for separate pre-training, offering a new paradigm for domain-adaptive segmentation.

Dapeng Zhang, Zhenlong Yuan, Zhangquan Chen et al.

Vision-Language-Action (VLA) models have recently shown strong decision-making capabilities in autonomous driving. However, existing VLAs often struggle with achieving efficient inference and generalizing to novel autonomous vehicle configurations and driving scenarios. In this paper, we propose Reasoning-VLA, a general and fast action-generation VLA framework. The proposed model employs a set of learnable action queries, initialized via Gaussian sampling from ground-truth trajectories within the training corpus. These learnable queries interact with reasoning-enhanced vision-language features to generate continuous action trajectories in parallel. To promote robust generalization, we consolidate eight publicly available autonomous driving datasets into a standardized, Chain-of-Thought reasoning-based, and easy-to-use data format for model training. Leveraging both supervised learning and reinforcement learning fine-tuning, extensive empirical evaluations across multiple benchmarks demonstrate that Reasoning-VLA achieves state-of-the-art performance, superior generalization capability, and the excellent inference speed reported to date.