Xintao Hu

Lin Zhao, Lu Zhang, Zihao Wu et al.

Artificial General Intelligence (AGI) has been a long-standing goal of humanity, with the aim of creating machines capable of performing any intellectual task that humans can do. To achieve this, AGI researchers draw inspiration from the human brain and seek to replicate its principles in intelligent machines. Brain-inspired artificial intelligence is a field that has emerged from this endeavor, combining insights from neuroscience, psychology, and computer science to develop more efficient and powerful AI systems. In this article, we provide a comprehensive overview of brain-inspired AI from the perspective of AGI. We begin with the current progress in brain-inspired AI and its extensive connection with AGI. We then cover the important characteristics for both human intelligence and AGI (e.g., scaling, multimodality, and reasoning). We discuss important technologies toward achieving AGI in current AI systems, such as in-context learning and prompt tuning. We also investigate the evolution of AGI systems from both algorithmic and infrastructural perspectives. Finally, we explore the limitations and future of AGI.

Zhengliang Liu, Tianyang Zhong, Yiwei Li et al.

The rise of large language models (LLMs) has marked a pivotal shift in the field of natural language processing (NLP). LLMs have revolutionized a multitude of domains, and they have made a significant impact in the medical field. Large language models are now more abundant than ever, and many of these models exhibit bilingual capabilities, proficient in both English and Chinese. However, a comprehensive evaluation of these models remains to be conducted. This lack of assessment is especially apparent within the context of radiology NLP. This study seeks to bridge this gap by critically evaluating thirty two LLMs in interpreting radiology reports, a crucial component of radiology NLP. Specifically, the ability to derive impressions from radiologic findings is assessed. The outcomes of this evaluation provide key insights into the performance, strengths, and weaknesses of these LLMs, informing their practical applications within the medical domain.

Tianyang Zhong, Zhengliang Liu, Yi Pan et al.

This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array of complex reasoning tasks, spanning multiple domains, including computer science, mathematics, natural sciences, medicine, linguistics, and social sciences. Through rigorous testing, o1-preview demonstrated remarkable capabilities, often achieving human-level or superior performance in areas ranging from coding challenges to scientific reasoning and from language processing to creative problem-solving. Key findings include: -83.3% success rate in solving complex competitive programming problems, surpassing many human experts. -Superior ability in generating coherent and accurate radiology reports, outperforming other evaluated models. -100% accuracy in high school-level mathematical reasoning tasks, providing detailed step-by-step solutions. -Advanced natural language inference capabilities across general and specialized domains like medicine. -Impressive performance in chip design tasks, outperforming specialized models in areas such as EDA script generation and bug analysis. -Remarkable proficiency in anthropology and geology, demonstrating deep understanding and reasoning in these specialized fields. -Strong capabilities in quantitative investing. O1 has comprehensive financial knowledge and statistical modeling skills. -Effective performance in social media analysis, including sentiment analysis and emotion recognition. The model excelled particularly in tasks requiring intricate reasoning and knowledge integration across various fields. While some limitations were observed, including occasional errors on simpler problems and challenges with certain highly specialized concepts, the overall results indicate significant progress towards artificial general intelligence.

Jiaqi Wang, Hanqi Jiang, Yiheng Liu et al.

In an era defined by the explosive growth of data and rapid technological advancements, Multimodal Large Language Models (MLLMs) stand at the forefront of artificial intelligence (AI) systems. Designed to seamlessly integrate diverse data types-including text, images, videos, audio, and physiological sequences-MLLMs address the complexities of real-world applications far beyond the capabilities of single-modality systems. In this paper, we systematically sort out the applications of MLLM in multimodal tasks such as natural language, vision, and audio. We also provide a comparative analysis of the focus of different MLLMs in the tasks, and provide insights into the shortcomings of current MLLMs, and suggest potential directions for future research. Through these discussions, this paper hopes to provide valuable insights for the further development and application of MLLM.

Chong Ma, Lin Zhao, Yuzhong Chen et al.

Shortcut learning is common but harmful to deep learning models, leading to degenerated feature representations and consequently jeopardizing the model's generalizability and interpretability. However, shortcut learning in the widely used Vision Transformer framework is largely unknown. Meanwhile, introducing domain-specific knowledge is a major approach to rectifying the shortcuts, which are predominated by background related factors. For example, in the medical imaging field, eye-gaze data from radiologists is an effective human visual prior knowledge that has the great potential to guide the deep learning models to focus on meaningful foreground regions of interest. However, obtaining eye-gaze data is time-consuming, labor-intensive and sometimes even not practical. In this work, we propose a novel and effective saliency-guided vision transformer (SGT) model to rectify shortcut learning in ViT with the absence of eye-gaze data. Specifically, a computational visual saliency model is adopted to predict saliency maps for input image samples. Then, the saliency maps are used to distil the most informative image patches. In the proposed SGT, the self-attention among image patches focus only on the distilled informative ones. Considering this distill operation may lead to global information lost, we further introduce, in the last encoder layer, a residual connection that captures the self-attention across all the image patches. The experiment results on four independent public datasets show that our SGT framework can effectively learn and leverage human prior knowledge without eye gaze data and achieves much better performance than baselines. Meanwhile, it successfully rectifies the harmful shortcut learning and significantly improves the interpretability of the ViT model, demonstrating the promise of transferring human prior knowledge derived visual saliency in rectifying shortcut learning

Xu Liu, Mengyue Zhou, Gaosheng Shi et al.

Linking computational natural language processing (NLP) models and neural responses to language in the human brain on the one hand facilitates the effort towards disentangling the neural representations underpinning language perception, on the other hand provides neurolinguistics evidence to evaluate and improve NLP models. Mappings of an NLP model's representations of and the brain activities evoked by linguistic input are typically deployed to reveal this symbiosis. However, two critical problems limit its advancement: 1) The model's representations (artificial neurons, ANs) rely on layer-level embeddings and thus lack fine-granularity; 2) The brain activities (biological neurons, BNs) are limited to neural recordings of isolated cortical unit (i.e., voxel/region) and thus lack integrations and interactions among brain functions. To address those problems, in this study, we 1) define ANs with fine-granularity in transformer-based NLP models (BERT in this study) and measure their temporal activations to input text sequences; 2) define BNs as functional brain networks (FBNs) extracted from functional magnetic resonance imaging (fMRI) data to capture functional interactions in the brain; 3) couple ANs and BNs by maximizing the synchronization of their temporal activations. Our experimental results demonstrate 1) The activations of ANs and BNs are significantly synchronized; 2) the ANs carry meaningful linguistic/semantic information and anchor to their BN signatures; 3) the anchored BNs are interpretable in a neurolinguistic context. Overall, our study introduces a novel, general, and effective framework to link transformer-based NLP models and neural activities in response to language and may provide novel insights for future studies such as brain-inspired evaluation and development of NLP models.

Yiheng Liu, Enjie Ge, Mengshen He et al.

Using deep learning models to recognize functional brain networks (FBNs) in functional magnetic resonance imaging (fMRI) has been attracting increasing interest recently. However, most existing work focuses on detecting static FBNs from entire fMRI signals, such as correlation-based functional connectivity. Sliding-window is a widely used strategy to capture the dynamics of FBNs, but it is still limited in representing intrinsic functional interactive dynamics at each time step. And the number of FBNs usually need to be set manually. More over, due to the complexity of dynamic interactions in brain, traditional linear and shallow models are insufficient in identifying complex and spatially overlapped FBNs across each time step. In this paper, we propose a novel Spatial and Channel-wise Attention Autoencoder (SCAAE) for discovering FBNs dynamically. The core idea of SCAAE is to apply attention mechanism to FBNs construction. Specifically, we designed two attention modules: 1) spatial-wise attention (SA) module to discover FBNs in the spatial domain and 2) a channel-wise attention (CA) module to weigh the channels for selecting the FBNs automatically. We evaluated our approach on ADHD200 dataset and our results indicate that the proposed SCAAE method can effectively recover the dynamic changes of the FBNs at each fMRI time step, without using sliding windows. More importantly, our proposed hybrid attention modules (SA and CA) do not enforce assumptions of linearity and independence as previous methods, and thus provide a novel approach to better understanding dynamic functional brain networks.

Tianyang Zhong, Wei Zhao, Yutong Zhang et al.

Radiology report generation, as a key step in medical image analysis, is critical to the quantitative analysis of clinically informed decision-making levels. However, complex and diverse radiology reports with cross-source heterogeneity pose a huge generalizability challenge to the current methods under massive data volume, mainly because the style and normativity of radiology reports are obviously distinctive among institutions, body regions inspected and radiologists. Recently, the advent of large language models (LLM) offers great potential for recognizing signs of health conditions. To resolve the above problem, we collaborate with the Second Xiangya Hospital in China and propose ChatRadio-Valuer based on the LLM, a tailored model for automatic radiology report generation that learns generalizable representations and provides a basis pattern for model adaptation in sophisticated analysts' cases. Specifically, ChatRadio-Valuer is trained based on the radiology reports from a single institution by means of supervised fine-tuning, and then adapted to disease diagnosis tasks for human multi-system evaluation (i.e., chest, abdomen, muscle-skeleton, head, and maxillofacial $\&$ neck) from six different institutions in clinical-level events. The clinical dataset utilized in this study encompasses a remarkable total of \textbf{332,673} observations. From the comprehensive results on engineering indicators, clinical efficacy and deployment cost metrics, it can be shown that ChatRadio-Valuer consistently outperforms state-of-the-art models, especially ChatGPT (GPT-3.5-Turbo) and GPT-4 et al., in terms of the diseases diagnosis from radiology reports. ChatRadio-Valuer provides an effective avenue to boost model generalization performance and alleviate the annotation workload of experts to enable the promotion of clinical AI applications in radiology reports.

Zhengliang Liu, Hanqi Jiang, Tianyang Zhong et al.

In this paper, we present a large-scale evaluation probing GPT-4V's capabilities and limitations for biomedical image analysis. GPT-4V represents a breakthrough in artificial general intelligence (AGI) for computer vision, with applications in the biomedical domain. We assess GPT-4V's performance across 16 medical imaging categories, including radiology, oncology, ophthalmology, pathology, and more. Tasks include modality recognition, anatomy localization, disease diagnosis, report generation, and lesion detection. The extensive experiments provide insights into GPT-4V's strengths and weaknesses. Results show GPT-4V's proficiency in modality and anatomy recognition but difficulty with disease diagnosis and localization. GPT-4V excels at diagnostic report generation, indicating strong image captioning skills. While promising for biomedical imaging AI, GPT-4V requires further enhancement and validation before clinical deployment. We emphasize responsible development and testing for trustworthy integration of biomedical AGI. This rigorous evaluation of GPT-4V on diverse medical images advances understanding of multimodal large language models (LLMs) and guides future work toward impactful healthcare applications.

Lin Zhao, Haixing Dai, Zihao Wu et al.

Artificial neural networks (ANNs), originally inspired by biological neural networks (BNNs), have achieved remarkable successes in many tasks such as visual representation learning. However, whether there exists semantic correlations/connections between the visual representations in ANNs and those in BNNs remains largely unexplored due to both the lack of an effective tool to link and couple two different domains, and the lack of a general and effective framework of representing the visual semantics in BNNs such as human functional brain networks (FBNs). To answer this question, we propose a novel computational framework, Synchronized Activations (Sync-ACT), to couple the visual representation spaces and semantics between ANNs and BNNs in human brain based on naturalistic functional magnetic resonance imaging (nfMRI) data. With this approach, we are able to semantically annotate the neurons in ANNs with biologically meaningful description derived from human brain imaging for the first time. We evaluated the Sync-ACT framework on two publicly available movie-watching nfMRI datasets. The experiments demonstrate a) the significant correlation and similarity of the semantics between the visual representations in FBNs and those in a variety of convolutional neural networks (CNNs) models; b) the close relationship between CNN's visual representation similarity to BNNs and its performance in image classification tasks. Overall, our study introduces a general and effective paradigm to couple the ANNs and BNNs and provides novel insights for future studies such as brain-inspired artificial intelligence.

Yuzhong Chen, Yu Du, Zhenxiang Xiao et al.

Vision transformer (ViT) and its variants have achieved remarkable successes in various visual tasks. The key characteristic of these ViT models is to adopt different aggregation strategies of spatial patch information within the artificial neural networks (ANNs). However, there is still a key lack of unified representation of different ViT architectures for systematic understanding and assessment of model representation performance. Moreover, how those well-performing ViT ANNs are similar to real biological neural networks (BNNs) is largely unexplored. To answer these fundamental questions, we, for the first time, propose a unified and biologically-plausible relational graph representation of ViT models. Specifically, the proposed relational graph representation consists of two key sub-graphs: aggregation graph and affine graph. The former one considers ViT tokens as nodes and describes their spatial interaction, while the latter one regards network channels as nodes and reflects the information communication between channels. Using this unified relational graph representation, we found that: a) a sweet spot of the aggregation graph leads to ViTs with significantly improved predictive performance; b) the graph measures of clustering coefficient and average path length are two effective indicators of model prediction performance, especially when applying on the datasets with small samples; c) our findings are consistent across various ViT architectures and multiple datasets; d) the proposed relational graph representation of ViT has high similarity with real BNNs derived from brain science data. Overall, our work provides a novel unified and biologically-plausible paradigm for more interpretable and effective representation of ViT ANNs.

Heng Huang, Lin Zhao, Xintao Hu et al.

Visual attention is a fundamental mechanism in the human brain, and it inspires the design of attention mechanisms in deep neural networks. However, most of the visual attention studies adopted eye-tracking data rather than the direct measurement of brain activity to characterize human visual attention. In addition, the adversarial relationship between the attention-related objects and attention-neglected background in the human visual system was not fully exploited. To bridge these gaps, we propose a novel brain-inspired adversarial visual attention network (BI-AVAN) to characterize human visual attention directly from functional brain activity. Our BI-AVAN model imitates the biased competition process between attention-related/neglected objects to identify and locate the visual objects in a movie frame the human brain focuses on in an unsupervised manner. We use independent eye-tracking data as ground truth for validation and experimental results show that our model achieves robust and promising results when inferring meaningful human visual attention and mapping the relationship between brain activities and visual stimuli. Our BI-AVAN model contributes to the emerging field of leveraging the brain's functional architecture to inspire and guide the model design in artificial intelligence (AI), e.g., deep neural networks.

Yiheng Liu, Junhao Ning, Sichen Xia et al.

The development of large language models (LLMs) is costly and has significant commercial value. Consequently, preventing unauthorized appropriation of open-source LLMs and protecting developers' intellectual property rights have become critical challenges. In this work, we propose the Functional Network Fingerprint (FNF), a training-free, sample-efficient method for detecting whether a suspect LLM is derived from a victim model, based on the consistency between their functional network activity. We demonstrate that models that share a common origin, even with differences in scale or architecture, exhibit highly consistent patterns of neuronal activity within their functional networks across diverse input samples. In contrast, models trained independently on distinct data or with different objectives fail to preserve such activity alignment. Unlike conventional approaches, our method requires only a few samples for verification, preserves model utility, and remains robust to common model modifications (such as fine-tuning, pruning, and parameter permutation), as well as to comparisons across diverse architectures and dimensionalities. FNF thus provides model owners and third parties with a simple, non-invasive, and effective tool for protecting LLM intellectual property. The code is available at https://github.com/WhatAboutMyStar/LLM_ACTIVATION.

Yiheng Liu, Xiaohui Gao, Haiyang Sun et al.

In recent years, the rapid advancement of large language models (LLMs) in natural language processing has sparked significant interest among researchers to understand their mechanisms and functional characteristics. Although existing studies have attempted to explain LLM functionalities by identifying and interpreting specific neurons, these efforts mostly focus on individual neuron contributions, neglecting the fact that human brain functions are realized through intricate interaction networks. Inspired by cognitive neuroscience research on functional brain networks (FBNs), this study introduces a novel approach to investigate whether similar functional networks exist within LLMs. We use methods similar to those in the field of functional neuroimaging analysis to locate and identify functional networks in LLM. Experimental results show that, similar to the human brain, LLMs contain functional networks that frequently recur during operation. Further analysis shows that these functional networks are crucial for LLM performance. Masking key functional networks significantly impairs the model's performance, while retaining just a subset of these networks is adequate to maintain effective operation. This research provides novel insights into the interpretation of LLMs and the lightweighting of LLMs for certain downstream tasks. Code is available at https://github.com/WhatAboutMyStar/LLM_ACTIVATION.

Yiheng Liu, Hao He, Tianle Han et al.

The introduction of ChatGPT has led to a significant increase in the utilization of Large Language Models (LLMs) for addressing downstream tasks. There's an increasing focus on cost-efficient training and deployment within this context. Low-cost training and deployment of LLMs represent the future development trend. This paper reviews the evolution of large language model training techniques and inference deployment technologies aligned with this emerging trend. The discussion on training includes various aspects, including data preprocessing, training architecture, pre-training tasks, parallel training, and relevant content related to model fine-tuning. On the inference side, the paper covers topics such as model compression, parallel computation, memory scheduling, and structural optimization. It also explores LLMs' utilization and provides insights into their future development.

Yiheng Liu, Junhao Ning, Sichen Xia et al.

Structured pruning is one of the representative techniques for compressing large language models (LLMs) to reduce GPU memory consumption and accelerate inference speed. It offers significant practical value in improving the efficiency of LLMs in real-world applications. Current structured pruning methods typically rely on assessment of the importance of the structure units and pruning the units with less importance. Most of them overlooks the interaction and collaboration among artificial neurons that are crucial for the functionalities of LLMs, leading to a disruption in the macro functional architecture of LLMs and consequently a pruning performance degradation. Inspired by the inherent similarities between artificial neural networks and functional neural networks in the human brain, we alleviate this challenge and propose to prune LLMs by identifying and preserving functional networks within LLMs in this study. To achieve this, we treat an LLM as a digital brain and decompose the LLM into functional networks, analogous to identifying functional brain networks in neuroimaging data. Afterwards, an LLM is pruned by preserving the key neurons within these functional networks. Experimental results demonstrate that the proposed method can successfully identify and locate functional networks and key neurons in LLMs, enabling efficient model pruning. Our code is available at https://github.com/WhatAboutMyStar/LLM_ACTIVATION.

Xintao Hu, Feng-Qi Cui

With the emergence of AI techniques for depression diagnosis, the conflict between high demand and limited supply for depression screening has been significantly alleviated. Among various modal data, audio-based depression diagnosis has received increasing attention from both academia and industry since audio is the most common carrier of emotion transmission. Unfortunately, audio data also contains User-sensitive Identity Information (ID), which is extremely vulnerable and may be maliciously used during the smart diagnosis process. Among previous methods, the clarification between depression features and sensitive features has always serve as a barrier. It is also critical to the problem for introducing a safe encryption methodology that only encrypts the sensitive features and a powerful classifier that can correctly diagnose the depression. To track these challenges, by leveraging adversarial loss-based Subspace Decomposition, we propose a first practical framework \name presented for Trustable Audio Affective Computing, to perform automated depression detection through audio within a trustable environment. The key enablers of TAAC are Differentiating Features Subspace Decompositor (DFSD), Flexible Noise Encryptor (FNE) and Staged Training Paradigm, used for decomposition, ID encryption and performance enhancement, respectively. Extensive experiments with existing encryption methods demonstrate our framework's preeminent performance in depression detection, ID reservation and audio reconstruction. Meanwhile, the experiments across various setting demonstrates our model's stability under different encryption strengths. Thus proving our framework's excellence in Confidentiality, Accuracy, Traceability, and Adjustability.

Haiyang Sun, Lin Zhao, Zihao Wu et al.

The human brain has long inspired the pursuit of artificial intelligence (AI). Recently, neuroimaging studies provide compelling evidence of alignment between the computational representation of artificial neural networks (ANNs) and the neural responses of the human brain to stimuli, suggesting that ANNs may employ brain-like information processing strategies. While such alignment has been observed across sensory modalities--visual, auditory, and linguistic--much of the focus has been on the behaviors of artificial neurons (ANs) at the population level, leaving the functional organization of individual ANs that facilitates such brain-like processes largely unexplored. In this study, we bridge this gap by directly coupling sub-groups of artificial neurons with functional brain networks (FBNs), the foundational organizational structure of the human brain. Specifically, we extract representative patterns from temporal responses of ANs in large language models (LLMs), and use them as fixed regressors to construct voxel-wise encoding models to predict brain activity recorded by functional magnetic resonance imaging (fMRI). This framework links the AN sub-groups to FBNs, enabling the delineation of brain-like functional organization within LLMs. Our findings reveal that LLMs (BERT and Llama 1-3) exhibit brain-like functional architecture, with sub-groups of artificial neurons mirroring the organizational patterns of well-established FBNs. Notably, the brain-like functional organization of LLMs evolves with the increased sophistication and capability, achieving an improved balance between the diversity of computational behaviors and the consistency of functional specializations. This research represents the first exploration of brain-like functional organization within LLMs, offering novel insights to inform the development of artificial general intelligence (AGI) with human brain principles.

Xiaohui Gao, Yue Cheng, Peiyang Li et al.

Neural encoding of artificial neural networks (ANNs) links their computational representations to brain responses, offering insights into how the brain processes information. Current studies mostly use linear encoding models for clarity, even though brain responses are often nonlinear. This has sparked interest in developing nonlinear encoding models that are still interpretable. To address this problem, we propose LinBridge, a learnable and flexible framework based on Jacobian analysis for interpreting nonlinear encoding models. LinBridge posits that the nonlinear mapping between ANN representations and neural responses can be factorized into a linear inherent component that approximates the complex nonlinear relationship, and a mapping bias that captures sample-selective nonlinearity. The Jacobian matrix, which reflects output change rates relative to input, enables the analysis of sample-selective mapping in nonlinear models. LinBridge employs a self-supervised learning strategy to extract both the linear inherent component and nonlinear mapping biases from the Jacobian matrices of the test set, allowing it to adapt effectively to various nonlinear encoding models. We validate the LinBridge framework in the scenario of neural visual encoding, using computational visual representations from CLIP-ViT to predict brain activity recorded via functional magnetic resonance imaging (fMRI). Our experimental results demonstrate that: 1) the linear inherent component extracted by LinBridge accurately reflects the complex mappings of nonlinear neural encoding models; 2) the sample-selective mapping bias elucidates the variability of nonlinearity across different levels of the visual processing hierarchy. This study presents a novel tool for interpreting nonlinear neural encoding models and offers fresh evidence about hierarchical nonlinearity distribution in the visual cortex.