Jinghao Lin

Qiwei Zeng, Hao Wang, Jinghao Lin et al.

Medical vision-language models (VLMs) have shown increasing potential for clinical image interpretation, including lesion detection and report generation. However, their practical utility remains limited by insufficient sensitivity to subtle lesions, whose visual evidence is often sparse, low-contrast, and embedded within complex anatomical context. As local visual tokens are aggregated, these weak lesion cues can become underrepresented in global image representations, making them difficult for medical VLMs to recognize. Existing efforts to improve lesion sensitivity mainly rely on medical-domain vision-encoder pre-training, clinical-term-guided alignment, or trainable pathological representation enhancement. Although effective, these approaches usually require additional training or model-specific adaptation and may overfit to particular disease morphologies, limiting their applicability to frozen medical VLMs. To address these limitations, we propose EasyLens, a training-free plug-and-play subtle-lesion representation amplifier for medical VLMs. EasyLens first constructs EasyBank, a pathology-anatomy prototype space that provides lesion-related prototypes and anatomy-aware normal references for comparing suspicious patches against both pathological and normal anatomical patterns. To avoid blindly amplifying normal tissues, EasyTag selects lesion-relevant patches through counterfactual prototype reasoning. To counteract the dilution of subtle lesion cues in global image representations, EasyAmplifier strengthens the selected lesion-relevant patch representations through morphology-guided residual enhancement, thereby increasing their contribution to the global image embedding. Experiments on multiple medical image datasets and frozen medical VLM backbones show that EasyLens improves subtle-lesion detection and outperforms existing encoder-enhancement baselines.

Zequn Sun, Jiacheng Huang, Jinghao Lin et al.

In this paper, we present the ``joint pre-training and local re-training'' framework for learning and applying multi-source knowledge graph (KG) embeddings. We are motivated by the fact that different KGs contain complementary information to improve KG embeddings and downstream tasks. We pre-train a large teacher KG embedding model over linked multi-source KGs and distill knowledge to train a student model for a task-specific KG. To enable knowledge transfer across different KGs, we use entity alignment to build a linked subgraph for connecting the pre-trained KGs and the target KG. The linked subgraph is re-trained for three-level knowledge distillation from the teacher to the student, i.e., feature knowledge distillation, network knowledge distillation, and prediction knowledge distillation, to generate more expressive embeddings. The teacher model can be reused for different target KGs and tasks without having to train from scratch. We conduct extensive experiments to demonstrate the effectiveness and efficiency of our framework.

Zihan wang, Hao Wang, Shi Feng et al.

Medical reasoning models remain constrained by parametric knowledge and are thus susceptible to forgetting and hallucinations. DeepResearch (DR) models ground outputs in verifiable evidence from tools and perform strongly in general domains, but their direct transfer to medical field yields relatively limited gains. We attribute this to two gaps: task characteristic and tool-use scaling. Medical questions require evidence interpretation in a knowledge-intensive clinical context; while general DR models can retrieve information, they often lack clinical-context reasoning and thus "find it but fail to use it," leaving performance limited by medical abilities. Moreover, in medical scenarios, blindly scaling tool-call can inject noisy context, derailing sensitive medical reasoning and prompting repetitive evidence-seeking along incorrect paths. Therefore, we propose DeepMed. For data, we deploy a multi-hop med-search QA synthesis method supporting the model to apply the DR paradigm in medical contexts. For training, we introduce a difficulty-aware turn-penalty to suppress excessive tool-call growth. For inference, we bring a monitor to help validate hypotheses within a controlled number of steps and avoid context rot. Overall, on seven medical benchmarks, DeepMed improves its base model by 9.79\% on average and outperforms larger medical reasoning and DR models.

Jianghang Lin, Haihua Yang, Deli Yu et al.

Multimodal Large Language Models (MLLMs) have shown transformative potential in medical applications, yet their performance is hindered by conventional data curation strategies that rely on coarse-grained partitioning by modality or department. Such fragmented approaches fail to capture the hierarchical and interconnected nature of clinical medical knowledge, limiting the models' ability to perform fine-grained recognition and complex reasoning. In this paper, we propose a novel Entity-Centric Medical Data Engineering framework. We automatically extract entities from authoritative medical literature to construct a Medical Entity Tree (MET), a hierarchical structure that systematically encodes diseases, anatomical structures, modalities, and symptoms into a unified knowledge repository. Building upon the MET, we propose an advanced data engine that includes: (1) node-guided retrieval to anchor raw data to specific medical concepts, (2) a two-stage hybrid filtering and alignment pipeline to ensure precise visual-semantic correspondence, and (3) knowledge-aware data synthesis to generate enriched captions and targeted reasoning VQA pairs, leveraging structural constraints. Extensive evaluations across six medical benchmarks demonstrate that our approach significantly enhances the medical capabilities of general-purpose MLLMs, improving their ability to handle complex clinical queries and achieve state-of-the-art performance in diverse medical contexts.

GLM-V Team, Wenyi Hong, Wenmeng Yu et al.

We present GLM-4.1V-Thinking and GLM-4.5V, a family of vision-language models (VLMs) designed to advance general-purpose multimodal understanding and reasoning. In this report, we share our key findings in the development of the reasoning-centric training framework. We first develop a capable vision foundation model with significant potential through large-scale pre-training, which arguably sets the upper bound for the final performance. We then propose Reinforcement Learning with Curriculum Sampling (RLCS) to unlock the full potential of the model, leading to comprehensive capability enhancement across a diverse range of tasks, including STEM problem solving, video understanding, content recognition, coding, grounding, GUI-based agents, and long document interpretation. In a comprehensive evaluation across 42 public benchmarks, GLM-4.5V achieves state-of-the-art performance on nearly all tasks among open-source models of similar size, and demonstrates competitive or even superior results compared to closed-source models such as Gemini-2.5-Flash on challenging tasks including Coding and GUI Agents. Meanwhile, the smaller GLM-4.1V-9B-Thinking remains highly competitive-achieving superior results to the much larger Qwen2.5-VL-72B on 29 benchmarks. We open-source both GLM-4.1V-9B-Thinking and GLM-4.5V. Code, models and more information are released at https://github.com/zai-org/GLM-V.

Baorong Shi, Bo Cui, Boyuan Jiang et al.

We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous medical corpora to broaden knowledge coverage and reduce long-tail gaps (e.g., rare diseases). For medical expert-level reasoning and interaction, MedXIAOHE incorporates diverse medical reasoning patterns via reinforcement learning and tool-augmented agentic training, enabling multi-step diagnostic reasoning with verifiable decision traces. To improve reliability in real-world use, MedXIAOHE integrates user-preference rubrics, evidence-grounded reasoning, and low-hallucination long-form report generation, with improved adherence to medical instructions. We release this report to document our practical design choices, scaling insights, and evaluation framework, hoping to inspire further research.

Hongze Tan, Jianfei Pan, Jinghao Lin et al.

Reinforcement learning (RL) is a pivotal task for enhancing Large Language Model (LLM) reasoning. Conventional algorithms, however, typically adhere to a coarse-grained credit assignment paradigm, applying a uniform reward to all tokens in a sequence, a critical flaw in long-chain reasoning tasks. In this paper, we address this challenge and propose Dynamic Entropy Weighting, a novel mechanism that facilitates fine-grained rewards through two new algorithms: Group Token Policy Optimization (GTPO), which assigns an entropy-weighted reward to each token, and the analogous algorithm Sequence-Level GRPO (GRPO-S). Our approach is founded on the hypothesis that high policy entropy within a reasoning path is a powerful heuristic for cognitive effort at pivotal junctures, which can be repurposed into a learning signal. By repurposing policy entropy for reward shaping, we achieve true per-token credit assignment. Experimental results across challenging reasoning benchmarks validate the superiority of our approach, showing our methods significantly outperform a strong DAPO baseline and confirming our entropy-weighting mechanism as the key driver of this performance boost.

Hao Wang, Shuchang Ye, Jinghao Lin et al.

Large vision-language models (LVMs) hold a great promise for automating medical report generation, potentially reducing the burden of manual reporting. State-of-the-art (SOTA) research fine-tunes general LVMs with medical data to align radiology images to corresponding medical reports. However, there are two key factors that limit these LVM's performance. Firstly, LVMs lack complex reasoning capability that leads to logical inconsistencies and potential diagnostic errors in generated reports. Secondly, LVMs lack reflection mechanism that leads to an inability to discover errors in the thinking process. To address these gaps, we propose LVMed-R2, a new fine-tuning strategy that introduces complex reasoning and reflection mechanisms for LVMs to enhance medical report generation. To the best of our knowledge, this is the first work to introduce complex reasoning to the medical report generation (MRG) task. Our proposed complex reasoning contains medical knowledge injection and perception-enhancing modules which improve the accuracy of LVMs diagnosis, coupled with a perception tree to provide guidance to limit the perception range. Further, the reflection mechanism forces self-verification for outputs to correct for potential errors. We experimented by fine-tuning LVMs with our proposed LVMed-R2 strategy, using IU-Xray and MIMIC-CXR datasets. Our results, measured on natural language generation (NLG) metrics and clinical efficacy (CE) metrics, demonstrate that LVMs fine-tuned with the proposed reflection mechanism possess the ability to correct outputs and complex reasoning effectively and improve LVMs performance for MRG.